Cheryl Coombs

#MISSING: Kieron, aged 12. Police are concerned for his safety & urgently want to hear from anyone who's seen him. Reported missing from the St Anns area of #Nottingham, last seen at 8am on Friday 20/03/26. If you've seen Kieron or know where he is, pls call #Notts Police on 101.

Will you join me in making this pledge? They cannot scrap juries unless we as a profession are complicit. We have the right to say no. Barristers, solicitors, paralegals and caseworkers up and down the land. Without us they have no Lammy Diplock Courts. Make your voice heard.

Keep bovaer in the news because if we don’t, it’ll be slipped into farm feeds with no benefit to the consumer whatsoever

Thiamine is not used to build the enzyme protein alpha-ketoglutarate needed to make ketones. It is used to make thiamine pyrophosphate, TPP, which is a required cofactor for the alpha-ketoglutarate dehydrogenase complex. With low thiamine, alpha-ketoglutarate dehydrogenase may still be present, but its activity can fall because it does not have enough TPP. That complex helps move carbon through the TCA cycle and generate reducing equivalents for mitochondrial energy production. Thiamine → TPP → TPP sits on E1 → TPP TPP is the “carbon-handling” cofactor for the E1 step. It does not build the enzyme alpha-ketoglutarate dehydrogenase. It lets the enzyme perform the difficult chemistry of alpha-keto acid decarboxylation. Keto does not bypass the thiamine-dependent downstream mitochondrial oxidation step. That means a person can still make ketones, measure ketones, be “in ketosis” and yet still have impaired energy extraction from that fuel if thiamine-dependent mitochondrial enzymes are not working due to thiamine insufficency or deficiency. Thiamine insufficiency and even deficiency is common. Its treated based on symptoms more than testing. I put people on good quality supplementation as supports to their ketogenic diet for healing in my online program for this reason. So in closing, no low thiamine will not impair your ketone levels the way carnitine insufficiency will. But it will impair the energy production you were hoping to experience in your ketogenic diet. And as we all know from dear @MitoPsychoBio with his latest substack this morning, energy matters.

My homemade lab… Regular Pharmacies don’t have 18 mg capsules. That needs to change. Because- Mixing it in water left lots of residue and gave me inconsistent doses. Inconsistent doses can worsen withdrawal symptoms or bring about relapses. A compound pharmacy was expensive and can take awhile to make. I tried that. Unfortunately sometimes I can’t eat due to drug induced Parkinsonism. Time is of essence. This is a much better solution for me. Most psychiatrists don’t understand how to safely taper off drugs. Thanks for all your help @GeorgiaEdeMD

3 year old St. Bernards looking for a forever home. #dubai #dogrescue Can some of the massive accounts help us? We're slammed here. We women don't get the same attention and it's all women rescuers here. 😭 @NiallHarbison @rickygervais @PeterEgan6

all the time and effort i spent fighting for a normal sleep schedule and one week of phosphatidylserine has me physically unable to remain awake past ~11pm and waking up naturally before 7 unbelievable

For the people living around Ayr, Prestwick and Troon. Can you keep an eye out for me? I was hit by a car last night and ran away. I've been spotted by the beach at 22.30 last night. Nothing since. I think I'm injured and might lie somewhere by now.

Absolutely sick to death of hearing about how the new @louistheroux documentary has made people think about attitudes to women. Lots of MPs jumping on the bandwagon. I mean, no disrespect to Louis - I’m grateful for the highlight - but for God’s sake… Women get killed by their partner every week. Tiny Man Tate has been a thing for years. Domestic violence shelters are overwhelmed. Women have been waving the red flags about incels and attitudes for years. We’ve been begging for change. We’ve been highlighting the serious threat of anti-women social media. Then a MAN makes a documentary and suddenly everyone’s interested? Do you not all think that this might be part of the problem?

@TheNoakesF Saw this and thought of you @ClausCarlsen1 @mimikmorgan @NewDawn7411 only because you guys don’t think my own egg habit weird.

Eggsperiment Time! Does it matter how you break a 16-hour fast? We’re studying how eggs vs other low-carb foods affect the body in adults following an LCHF lifestyle. If you’ve been following LCHF for more than 3 months and are willing to follow a 16:8 fasting protocol, you may qualify to participate in this 6-week study. Interested or want more information? Contact Karen at karen@thenoakesfoundation.org @ProfTimNoakes #TheNoakesFoundation #LCHF #MetabolicHealth #Eggsperiment #IntermittentFasting

@ken_trails @robertlufkinmd I think they are talking about protein sparing modified fast - so 500 to 900 calories per day of just lean protein, egg white, chicken, prawns that kind of thing. The idea is to get all the benefits of fasting without losing muscle mass.

@robertlufkinmd What’s a “fasting mimicking diet?” Seems self defeating. Many thanks!

I teach medical students that autophagy -- the body's cellular "recycling system" -- is one of the most powerful anti-aging mechanisms we have. Until now, we had no direct human proof that fasting triggers it. That just changed. Cedars-Sinai researchers ran the first human trial measuring autophagic flux during a 5-day fasting-mimicking diet. Results: - Measurable increase in cellular recycling (autophagy flux) - Improved insulin sensitivity (HOMA-IR dropped by 1.6) - Lower fasting glucose - Effect persisted even 2 days AFTER resuming normal eating The key finding? It's not just about eating less. Macronutrient composition matters -- only the ProLon formulation triggered lasting autophagy. Calorie restriction alone was not enough. In "Lies I Taught in Medical School," I explain why we overlooked the metabolic roots of disease. This study shows your cells can literally clean house -- if you give them the right signals. Full breakdown coming on the Health Longevity Secrets podcast. Source: pubmed.ncbi.nlm.nih.gov/41372565/ #Autophagy #Fasting #MetabolicHealth #Longevity #AntiAging

One last beautiful push towards recruitment for my study. Eligibility criteria are as follows: Adults (18 years and older) or adolescents (ages 14-17) with signed parental consent. Must be using or have used a ketogenic diet as part of treatment for mental illness. Must have prior baseline and follow-up scores showing at least a 50% improvement on mood assessment (such as PHQ-9, GAD-7, DASS, PCL-5, or other validated instruments relevant to prior or existing diagnosis). Stable in the use of the ketogenic diet and not currently receiving regular consultation from a dietary professional. Self-reported confirmation of ketone levels at some point during the ketogenic diet treatment (through blood, breath, or urine). Currently, self-identify as recovered or in the process of recovering from a mental illness categorized under DSM-V. Must be physically present in the United States at the time of participation. mentalhealthketo.com/ketogenic-diet… Please share!

Martyna Ogonowska, a UK rape survivor who, at 18, stabbed a man to death in self-defense as he sexually assaulted her, has just lost an appeal of her 17 year prison sentence. This, lest we forget, is the same court system which failed to prosecute the adult man who raped Ogonowska when she was 14 because a judge decided that she’d consented, and which also recently handed out a suspended sentence to a man who raped a 13 year old because he told the judge that he “didn’t know it was illegal,” and because had been taught in his UK madrassah that British women and girls “have no more value than a piece of candy that has been dropped on the ground. It seems that the British justice system agrees.

🚨 JUST IN: In a jaw-dropping declaration, Crown Prince Reza Pahlavi announced his long-prepared "Transition System" is now fully staffed with qualified Iranians inside and outside the country and ready to take control the moment the Islamic Republic collapses.

@7NewsMelbourne @georgia_bm_ In Australia, there is more punishment for a woman creating a female only space than there is for a man secretly filming 150 women in what should be a female only space.

@ImWatson91 You really should have your own catering company Sinead. You know buffet spreads for Wedding Christening birthdays parties.

Baked my brother from another mother the fudgiest chocolate fudge cake, seeing as the old fart turns 45 today - happy birthday, Baz! 🥳

There is a number attached to beef that gets cited at dinner parties. 15,000 litres per kilogram. Almonds: 3,500. Avocados: 2,000. Pistachios: 11,400. Beef, the headline says, uses more than all of them. Here is the thing nobody mentions at the dinner party. Water has categories. Green water: rainfall. Falls on a field, absorbed by vegetation, returned to the atmosphere. Recycled. Continuous. Not extracted from anything. The rain was going to fall on that land whether Gerald was on it or not. Attributing it to the animal standing in it is an accounting choice, not a physical reality. Blue water: groundwater and surface water. Pumped from rivers, drawn from aquifers. The water that, when it's gone, is gone. The water that is sinking the San Joaquin Valley. The number that matters. Gerald's blue water per kilogram of beef: approximately 50 litres. Californian almonds: 3,785 litres. Per kilogram. From an aquifer that took centuries to accumulate. The 15,000 litre figure is almost entirely green water. British rainfall, on British fields, falling regardless of Gerald. The dinner party number is the wrong number. The right number is 50 litres, and the almonds aren't close.

To be clear: the tenure of a Prime Minister shouldn't be at the convenience of his Party's MPs. If allegations that a Prime Minister has repeatedly lied or misled the House, then it is a matter of national importance those allegations are investigated promptly, irrespective of whether it's untimely for his Party.

@TrimpeChristine @drjasonfung Yes that page is important for many of us

Hey Cheryl! Ohhh, that's such a hard question to answer...but honestly, the first thing that changed my life was hearing @drjasonfung plainly saying, "This is not your fault...you've been given bad advice for years!" I literally got tears in my eyes and felt the weight of shame lifting. So, I immediately took his advice to remove the remaining high-carb foods from my diet (I was still eating bread, potatoes, rice, and pasta) and stopped eating when I was NOT hungry. The subtitle of his book, The Obesity Code, is: Unlocking the Secrets of Weight Loss... And he did that for me! I'm so grateful to him and to God (I saw His hand over my journey step by step)!

@TrimpeChristine @CoachDanGo What was it that made such the big difference for you Christine? The fasting ? Or acknowledging the healthy choices sold to you were actually processed foods which look like a good choice but actually aren’t.

Former fattie here, I agree with you wholeheartedly (the doctor and the need for proper diet) and I rarely listen to reels like this, but she looks so distressed, I did—and since I can relate to what she says, I can see some of her points and her reality. Is she completely honest with herself? NO. Neither was I. And I was given horrible advice for decades. @drjasonfung changed everything for me—finally sharing metabolic health wisdom I desperately needed. I do know and take full responsibility for my health (even if bad advice kept me in the obesity cycle for three decades). I am on a mission to help these women. I’m not even sure why I’m commenting, other than to say—I want this problem to be resolved 💔❤️‍🩹❤️ Freedom is possible. And honestly, the heavy weight of shame I carried was worse than the 100 extra pounds. #SugarFreed

The doctor is right. If you're eating so much that it makes you obese it's not a proper diet.