Benjamin W Blue

Different hemispheres, same team! Ora co-founder Brian Kennedy takes the stage at the Mauritius Longevity Summit!

@KristerKauppi @agelessrx_ @OraBiomedical @ParrasAlbert @CityOfViva Always excited to work alongside you Krister!

Big thanks to our collaborators @agelessrx_ @OraBiomedical @ParrasAlbert (VivoArchitect) @CityOfViva

On a microscopic level we are able to revert cellular age thanks to reprogramming. This is the closest we have come to cellular radical life extension. In just 3 days Rapamycin Longevity Lab goes live with groundbreaking research on partial reprogramming on @pumpdotscience together with Reprogramming Lab (@reproglab). Later next week we’ll take the next step by combining partial reprogramming with mTOR inhibitors such as Rapamycin and Omipalisib to explore whether we can push longevity effects even further. Join the live online event on November 10th. Link below.

What a journey it has been when looking back! 1⃣ In October 2023 I had a conversation with the researcher Matt Kaeberlein and he mentioned that he will launch a new company Ora Biomedical where it will be able to do cost-effective and high throughput lifespan screens on compounds in worms. It sounded very interesting and I proposed that we should set up a research project to screen mTOR inhibitors to see if we can find something better than Rapamycin, the most robustly validated longevity drug to date. So I started the Rapamycin Longevity Lab and prepared a launch of the project for next year. 2⃣ I initiated a very small pilot screen of five compounds and thanks to that project we discovered that Omipalisib (GSK2126458) has promising lifespan effects. The best recorded median lifespan is 63%. 3⃣ In May 2024 I went to the Longevity Biotech Fellowship camp in Spain and during the dinner a guy was talking about the discovery of Omipalisib and his data around it. He also mentioned that another lab "Rapamycin Longevity Lab" had also discovered the same thing. Another guy at the table interrupted him and said that the founder of the "Rapamycin Longevity Lab" sits over there and points at me. That was how the researcher Alejandro Ocampo and I met and had very interesting discussions afterwards. 4⃣ Since 2024 partnership and collaboration has been built up with different people, labs and companies. Some initial experiments have also been done in flies with promising lifespan-enhancing effects and we are also looking at other models to test Omipalisib in. It is also great to see that we are taking steps closer to mice studies step by step thanks to our launch of the $OMIPAL token on @pumpdotscience! Reach out if you want to collaborate or support the progress around the longevity research of Omipalisib. PS. Very soon today the pump.science team will reveal the latest lifespan-extension results in worms with Omipalisib!

This is the day I have been waiting for and it’s time to start to release preliminary data from the first phase of the lifespan screening of 301 of 601 compounds in roundworms. Below is the current top list of the 37 compounds. Out of the 301 compounds tested 5 have produced a higher median lifespan extension than than the best recorded lifespan of Rapamycin which is 27%. My three key takeaways from this is 1⃣ When I started to look deeper at the compounds in the top list I was surprised that there were 3 compounds that indirectly activated mTOR instead of inhibiting it. This unexpected result turned out to be fortunate because the goal was to screen 601 mTOR inhibitors and not look at mTOR activators. It’s still early data but this challenges the assumption that mTOR activators would be connected to a decrease in lifespan. It’s very interesting data points that we have provided to the field and more research is of course needed here to understand why they seem to work and if it translates to other species as well. Due to all this a decision has been taken to change the project name from “Rapid lifespan analysis of 601 mTOR inhibitors” to “Rapid lifespan analysis of 601 mTOR modulators” to better reflect the scope. It is also good to point out that most of the compounds are mTOR inhibitors in the library according to the chemical company provider. 2⃣ It was discovered that the ATP-competitive mTOR kinase inhibitor PQR626 has lifespan extension properties that is better than Rapamycin. This is interesting because this compound targets both mTORC1 and mTORC2 unlike Rapamycin which targets directly mTORC1. This, and other data in the top list, challenges a bit the current view that mTORC1 inhibition is connected to lifespan and mTORC2 is connected to decrease in lifespan. Additional validation in other species such as mice will be key here. The goal is to send in proposals to both ITP and CITP next year for testing the PQR626 compound. Proposals for testing Omipalisib were submitted earlier this year. 3⃣ Every compound in this screen was tested at just one dose. That means potential for further lifespan extension if the dose is optimized. We will test different doses of both PQR626 and Omipalisib to see if we can optimize them even more. If someone is interested in testing any of the compounds that have been screened in other species or strains please reach out. Let’s collaborate! PS 1. @OraBiomedical is validating the rest of the data and when this is done it will be published to their database and Rapamycin Longevity Lab LID database. PS 2. Funding Need: We’re still seeking $28600 to finish screen of the remaining 300 compounds. If you’d like to support then please reach out to me!

@biogerontology A great example of why longbio needs to cast a wider net when it comes to advancing drug discovery. At @OraBiomedical we want to get the field even closer to the fin-ish line, even if it means sometimes swimming against the current. What matters is that longbio doesn't flounder!

Oh, please give it to salmon! Imagine - RapaMaki! 🍣

Super excited to see Ora get to do more incredible C. elegans work!

So excited to spread the news about our latest NIH grant! This technology development award further cements the #wormbot platform as the best-in-class for longitudinal phenotype analysis and longevity drug discovery! #millionmoleculechallenge orabiomedical.com/wp-content/upl…

Awesome to see @OraBiomedical’s work being shown off at AGE2024! Thanks to all the amazing sponsors of the #millionmoleculechallenge

@OraBiomedical is solving the problems that prevent Humans from achieving their most audacious goals. 1. Find the absolute best longevity interventions. 2. Discover transformative new use cases. We're going to space, and #LongevityMedicine is going to make it possible.

Our latest, in Lab on a Chip. Super cool and super high tech — and super hard to get right. 10 years of work to figure out a way of automating high precision demography in C. elegans: The Egg Counter! pubs.rsc.org/en/content/art…

Cool interview about what we're doing at @OraBiomedical! Thanks @OptispanPodcast for highlighting us! youtube.com/watch?v=Lon8J-…

@OraBiomedical’s director of invertebrate research Michael Muir generating buzz at LSINW2024.

Awesome to see the work we're doing at @OraBiomedical featured as part of the @NUSingapore Healthy Longevity webinar program! Check out the orabiomedical.com/mmcleaderboard/ to see more results roll in weekly! youtube.com/watch?v=eedfbv…

Stop what you are doing and look through the latest data on lifespan extending interventions! To my knowledge, this is the largest dataset created solely through the advice and sponsorship of everyday people. Citizen science for the win! #millionmoleculechallenge #wormbot

We’ve revamped our membership program at A4LI! For only $50/year, members will receive A4LI swag, insider content/access to the longevity-political advocacy effort, as well as exclusive discounts to products, services and conferences in the longevity space. While we believe that our mission is reason enough for members to join, we hope that the thousands of dollars in potential savings on our Discount Marketplace will encourage a broader audience to support our advocacy efforts. Currently, we’re offering exclusive discounts to our members on: - Conference tickets to the @LongevityGL’s Longevity Summit (CA), @LongevityDublin’s Longevity Summit Dublin and @foresightinst’s Foresight Vision Weekend - Diagnostic tests from @glycanage, @TruDiagnostic and @GenerationLab_ - Baseline health services from @optispan and Vitaliti - Products from @OneSkinTech and @DelavieSciences We will be continuously adding to the list of longevity-related products for our members, so make sure to check back regularly! Support our mission aimed at increasing healthy lifespan, and help us create a future where everyone can live better for longer – become a member today! Link here: a4li.org/register/becom…

Spread the word today: longevity medicine needs your support! Please reach out to your congressional rep and tell them longevity medicine is the future of health and you support it! house.gov/representative… #longevitymedicine #geroscience #longevitybiotech

The solution to #6: support the Million Molecule Challenge. orabiomedical.com/sponsor-mmc/ Step up now, and in 12 months we'll have an open-access 20,000+ longevity intervention database with a bunch of stuff that beats the pants off anything we know about today. Or for the same investment, we can find a few small effect size genes in people or test 5 new things in mice, none of which will come close to caloric restriction. youtube.com/watch?v=kEzRU_… @jamesfickel @RohanKrajeski @OraBiomedical

The Longevity Olympics - Week 2! 1st - USA 2nd - Germany 3rd - Sweden Surprisingly, the rankings stayed the same! USA broadened its lead. Germany and Sweden solidified 2nd and 3rd place positions with new sponsorships! What country will emerge to shake up the leaderboard?

@senolix100 @OraBiomedical 💪 There are quite many biohackers here in northern Europe so I hope more of these people will find what a great tool the wormbot is to start making new revolutionary longevity discoveries in the gold mine in front of us 🙏

@OraBiomedical is your team of longevity researchers! Put us to work and let's change the future of health together! #millionmoleculechallenge #wormbot