Anurag Sethi [email protected]

Nothing wrong with using AI to analyze your genome but please do not naively believe AI based analyses of genomic information without consulting clinical geneticists, physicians & genetic counselors. Lots of snake oil salesmen in this space.

A side effect of more weakly trained biologists entering techbio is we’re just scaling the same irrelevant experiments that are a root cause of drug failures. Pharma companies have already run more automated screens in these models than you can imagine.

Anurag Sethi, Principal Data Scientist, studies large human cohorts to better understand aging. He turns complex data into insights that inform our research and drug discovery programs. Anurag shares what makes his work rewarding. calicolabs.com/life-at-calico #AgingScience

We are pleased to announce that the IITB Mars Rover Team has secured second place in the European Rover Challenge – Remote Formula, among 20+ participating international teams. Our Autonomous & Software subdivision developed an autonomous exploration and navigation framework leveraging the ROS middleware integrated with the Unity simulation platform. This framework enabled the rover to operate in the Mars yard simulated testing environment, performing tasks such as terrain mapping, object detection and obstacle avoidance, autonomous decision-making for exploration, and path planning towards designated goals. This achievement highlights the potential applications of our work in diverse areas of autonomous robotics, including self-driving vehicles, drone-based reconnaissance, and warehouse automation. Many thanks to Faculty Advisor Prof. P. J. Guruprasad for his continued guidance. #ERC2025 #Robotics #AutonomousSystems #IITB

One of the most epic framings of human genetics that lives rent-free in my head: "The human population, through explosive growth, has performed a comprehensive saturation mutagenesis experiment on itself. It is now the case that any single base substitution that is compatible with life is expected to be present somewhere among the nearly 8 billion living humans. Humanity has thus, in effect, done many of the natural experiments required to understand our own genotype-phenotype map; this leaves geneticists to catalog the outcomes of those experiments, and to leverage both observational and experimental approaches to understand the mechanisms by which variants alter biology." Such a beautiful idea. Human genetics remains our greatest source of predictive validity for new drug mechanisms. And we're just scratching the surface.

🏏 25 days. 5 battles. Scores tied 2-2. This isn’t just a game — it’s Test Cricket in all its timeless glory. A series for the ages. Hats off to IND & ENG for the drama, grit, and greatness.

@bhogleharsha No lead spinner for England and they are going in with 3 swing bowlers. Pitch is going to be green.

Wow, no Stokes, no Archer, likely no Bumrah. Opportunity for many others to show they can be match winners. Only hope they don't put out a flat deck.

@MichaelVaughan Bumrah!

Perfect morning for England so far .. the chase is on .. Is there a better all format player than Ben Duckett ? #ENGvIND

Well at least we now know it only takes one moron in the wrong position surrounded by yes men to tank the world economy.

It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on NIH-funded research—that’s all 210 drugs. But what the public sees is just the tip of the iceberg. Pharma takes credit for the final product, but beneath each drug developed, there are ~20 years of basic research, and 90% of the cost is from basic research funded by the NIH, which discovers drug targets, understands disease mechanisms, and creates life-saving treatments. Figuring out how cancer evades the immune system, how addiction rewires the brain, and how heart disease develops is the role of the NIH, creating the foundation for the breakthrough drugs that come 20 years later, and the NIH does all that with only 0.8% of the US budget. Without NIH, there would be no cancer immunotherapy, no anti-overdose medication, no anti-heart attack or stroke medication, no cutting-edge treatments. If NIH funding is cut, the iceberg will melt. That means fewer cures, more suffering, and more lives lost. The science beneath the surface keeps us afloat. Invest in NIH. Invest in life

I shake my head as people actually think DOGE has identified waste, fraud and abuse in 5 days. What they are doing is gutting programs they don't like according to Project 2025. They haven't done any analysis and don't even know the functions of the departments they are cutting.

Although genome-wide association studies are often performed on ratios composed of a numerator trait divided by a denominator trait, @HGGAdvances latest article recommends a covariate-adjusted or multivariate model to provide clearer interpretations: cell.com/hgg-advances/f… #ASHG

Just found out that we have an immediate postdoc opening for US nationals (citizens/green-card holders). Needs to be filled within 6 months. Lots of fun topics (e.g. biosensors, brain genomics, AI for bio, &c). If interested, see jobs.gersteinlab.org & contact me.

train yourself to take nothing personally.

me when they ask me if the assumptions of my model hold in practice

.@elonmusk I did listen to the climate part and yeah, I do think it was dumb. I don't expect @realDonaldTrump to know the nuances of various CO2 ppm levels and their consequences, and him reaching out to the person who has arguably done more for climate than anyone else is pretty sensible. You had a responsibility that I think you largely abdicated by downplaying the reality of things.

@dr_alphalyrae Interested

Last 3 years I have been an active member of a community on software for bio. Today I have to face the reality that this community, that used to consist of thoughtful operators wanting to talk about science+tech has now become overrun with loud, obnoxious and generally ignorant people. Not sure what is next but I am hoping to find a different platform/third place to share writing and thoughts. If it doesn’t exist I will create it - anyone interested please DM me.

I want an open process at the convention and not a coronation. The key still is who can best beat @realDonaTrump above all other priorities given how much a danger he is.