Brian Wrobs

325 posts

Brian Wrobs

Brian Wrobs

@brianwro

Entrepreneur. Golfer. Husband. Teacher. Volunteer. Board Member. Big Brother.

Milwaukee, WI Katılım Mayıs 2010
252 Takip Edilen247 Takipçiler
Brian Wrobs
Brian Wrobs@brianwro·
@ajw02360 Intelligence isn’t for everyone. Your post helps confirm it. We can let this play out and watch the scoreboard.
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AJW
AJW@ajw02360·
@brianwro Not with 1.6 billion shares OS. Most large short squeezes are either stocks with a very small OS and float. There might be a short squeeze but it won’t be anywhere near the top 100, let alone top 5. I find it hard that you people believe some of the stuff you post. Ignorance, or?
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Brian Wrobs
Brian Wrobs@brianwro·
$NWBO Mark this down. This company and its string of successes and bio technology will create one of the biggest (top 5) short squeezes in stock market history. It’s bottled up.
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Brian Wrobs
Brian Wrobs@brianwro·
@andrewcaravello Understand this, and you will understand the immense power of $NWBO long-term. There is no short seller or MM in the world that can mask this power once unleashed.
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Andrew Caravello, DO
Andrew Caravello, DO@andrewcaravello·
$MRNA cancer vaccine just terminated in skin cancer. The trial enrolled 46 of a planned 412 patients, ended for “business reasons” with no efficacy data released. Here is why it failed, and why it was always going to fail in this population. The $MRNA approach (developed in partnership with $MRK, whose #Keytruda formed the checkpoint inhibitor arm of the terminated trial) sequences the patient’s tumor, identifies the unique mutations on the cancer cells, and packages those mutations into an #mRNA vaccine. When the patient gets the shot, the mRNA enters their own dendritic cells (the immune system’s teachers), which then translate the mRNA, display the tumor markers on their surface, and instruct T cells to find and kill cells carrying those markers. The mRNA is the lesson plan. The patient’s own dendritic cells are the teachers. The problem is the teachers. Most cancer patients are over sixty, and by that age the body’s teaching cells have largely gone quiet. Decades of inflammation have silenced the master gene (IRF8) that defines a functional teacher cell. A paper from Pittsburgh published this month showed that even in laboratory-prepared dendritic cells, only one in fifty to one in a hundred is actually capable of giving the immune system the right instruction. In the body of a person over sixty, the working fraction is even smaller. $MRNA delivered a perfect lesson plan to a classroom of teachers who can no longer teach. The students (CD4 helper and CD8 cytotoxic T cells) hear the lesson but get the wrong message, becoming tolerant or unresponsive instead of cytotoxic. There is a second problem the $MRNA approach cannot solve. Tumors mutate quickly. The first wave of T cells kills the cancer cells displaying the targeted markers. The cells that survive are the ones that learned to hide those markers. Within weeks, the tumor escapes. This is the escape variant problem that has limited every targeted cancer therapy from CAR-T forward. Two weeks before $MRNA termination, Dr. Pawel Kalinski at the University of Pittsburgh gave a public lecture explaining exactly why this approach would fail and what the solution looks like. His platform manufactures the teacher cells outside the body, in a clean environment where the silencing has not occurred, then sorts for the rare productive subset that actually produces the instructional signal at full strength. The CD4 and CD8 T cells these manufactured teachers educate recognize cancer cells through two mechanisms instead of one: the specific tumor marker AND a stress signal (NKG2D recognizing MIC-A) that cancer cells cannot easily hide from both recognition systems at once. Escape variants get caught by the second recognition system. In his clinical work, this approach produced complete or near-complete responses in seven of nine breast cancer patients in a recent trial. $NWBO owns this platform. Their #DCVax dendritic cell vaccine is built on Kalinski’s technology, manufactured under license from Pittsburgh and Roswell Park. The forward extension Kalinski’s lab is now developing pairs the manufactured teacher with the patient’s own T cells in a closed bioreactor where the teaching signal is delivered correctly, then potentially infuses both the teacher and the educated students back into the patient. The teacher would establish a permanent immune outpost at the injection site. The students would travel through the body and find cancer cells through the dual-recognition system that no current cancer therapy uses. $MRNA model: deliver the lesson plan, hope the teachers can still teach. $NWBO model: build the teacher, deliver the working teacher with the lesson plan already inside, let the working teacher do the instructing. When the teachers in the patient’s body have gone quiet, only one of these models works. Two weeks ago Kalinski explained why. This week $MRNA confirmed it.
Stephanie Seneff@stephanieseneff

A major setback for mRNA cancer vaccine technology. A closely watched phase 2/3 trial of Moderna's product to treat cutaneous squamous cell carcinoma was prematurely terminated, without revealing the reasons for aborting the trial. trialsitenews.com/a/moderna-and-…

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Brian Wrobs
Brian Wrobs@brianwro·
@ajw02360 @METhompson72 @jaygreco194737 Finally, there needs to be a presumption that all of this is being aligned in proper order, and that behind the scenes, the regulation discussions, pricing, supply chain, litigation - everything is strategic in the end. It is a grandmaster playbook.
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AJW
AJW@ajw02360·
@METhompson72 @jaygreco194737 Mark, you need to understand that some investors in $NWBO are cult-like. They get these delusional ideas of $20-$30-$40 SP and if you don’t go along with this narrative you will be labeled a short. It’s hard to have a reasonable conversation with them
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Mark Thompson
Mark Thompson@METhompson72·
Time to put a price target on $NWBO. I am in at 20c. With MHRA approval for DC-VAX anything is possible, so this is a real thumb-suck, but $2.00 does not seem unreasonable.
Mark Thompson tweet media
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Brian Wrobs
Brian Wrobs@brianwro·
@ajw02360 @METhompson72 @jaygreco194737 Of course you will find some people that are intolerable to any negativity. Much like you will find the exact opposite, which is the buffoons on the short side that know nothing about this technology or industry and are simply bashing. The 90% in the middle understand both sides.
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Brian Wrobs
Brian Wrobs@brianwro·
@ajw02360 @METhompson72 @jaygreco194737 I think this is a tremendously unfair critique. Those who believe in the $10-$30+ range understand the science, the repeatability, and the overall market sizing. They understand the lead that $NWBO is currently in relative to trial data and supply chain.
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AJW
AJW@ajw02360·
@Maik_Kunde @METhompson72 This. Finally someone with some common sense. These fools talking $10/$20/$30 have no idea of the amount of work $NWBO will need to do to get the SP to these kind of numbers. They will need to execute flawlessly and show significant increase in revenue and income. Ways off
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Ron Greco
Ron Greco@gr197667·
$NWBO @Citadel @SECPaulSAtkins @kshaughnessy2 @POTUS @WhiteHouse @ThomasOwenMcCa1 7.3 million up .02 .. really Kenny G?? You say you control the price so when will reality set in for u? Can’t make this fraud up.. Paulie where is the new day?? I mean one of your 6 buddies caved .. already .. so just a matter of time.. someone other than the 7 crooks has the playbook.. right Kenny G?
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Frank Goldwater
Frank Goldwater@GoldwaterF98498·
$NWBO Again, the stock is manipulated and the SP rise 15-20% and share hoders are starting to believe the day has come. It hasn't. SP will go back around $0.20 because MM's have their plan.
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TonyVerrazzanno
TonyVerrazzanno@TonyVerazzanno·
$NWBO Ever thought about the fact it would be way cheaper for MM's to make $NWBO bankrupt before a ruling than to pay the fine?
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James Woods
James Woods@RealJamesWoods·
This is unfixable.
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Brian Wrobs
Brian Wrobs@brianwro·
@Tiggersdad2 @AndresL04854206 @jaygreco194737 Kind of simple, actually. You have no basis for your argument, and it appears through your writing as though you are about as uninformed as the bots that exist in X land. If your allegations were rooted in science, or you had some reasonable defense to the position, fine. But…
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jay greco
jay greco@jaygreco194737·
$NWBO $GDC To the NWBO community…. This is not financial advise..have never made a post like this.. ever. But as we await the knuckle heads in the UK for approval … an anomaly has developed in the last week that is worth your DD. GDC.. research it .. and go from there.. GDC USA company is number 15 globally in BTC holdings … current BTC price $600 million on their balance sheet.. Stock closed at .16 cents on Friday .. folks with decent IQs can figure this out. FTDs have created this anomaly.. Again not financial advise.
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Hoffmann
Hoffmann@hoffmann6383·
I wrote an article about $NWBO: reddit.com/r/NWBO/comment… I encourage everyone to read it. What is happening with NWBO is astounding and our persistent retail investor has hung on through it all. I believe we will all be much better off when this story comes to its' ending.
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Brian Wrobs
Brian Wrobs@brianwro·
It is more bullish than one might think. The interesting language here, though of course glioblastoma is addressed, is the mention that $NWBO handles “solid tumor cancers” (not just gb), and the “cancer vaccine platform” (again not gb or limited). Very good verbiage and timely.
StonkMaster@StonkMasterJ

$NWBO Spin it however you'd like, this is bullish. Northwest Biotherapeutics Appoints Dr. Annalisa Jenkins As Strategic Adviser To Advance Dendritic Cell Cancer Vaccine Platform prnewswire.com/news-releases/…

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Brian Wrobs
Brian Wrobs@brianwro·
@elonmusk Holy shit. Never knew this. This is not okay, even if the facts slightly differ from the other side.
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Elon Musk
Elon Musk@elonmusk·
Scam Altman and Greg Stockman stole a charity. Full stop. Greg got tens of billions of stock for himself and Scam got dozens of OpenAI side deals with a piece of the action for himself, Y Combinator style. After this lawsuit, Scam will also be awarded tens of billions in stock directly. The fundamental question is simply this: Do you want to set legal precedent in the United States that it is ok to loot a charity? If so, you undermine all charitable giving in the United States forever. I could have started OpenAI as a for-profit corporation. Instead, I started it, funded it, recruited critical talent and taught them everything I know about how to make a startup successful FOR THE PUBLIC GOOD. Then they stole the charity.
X Freeze@XFreeze

Interesting how it works Elon puts up his own money, rounds up the absolute best AI talent on the planet, leverages every connection he has to secure serious resources, and launches OpenAI in 2015 as a pure non-profit explicitly created to develop AI for the benefit of humanity, with zero profit motive and open research Then the “team” decides they want the bag They push Elon out, take control, and quietly flip the entire thing into a for-profit machine All while preaching the same sanctimonious lines on repeat: “We’re still mission-driven!” “AI for the good of humanity!” “We’d never abandon our principles!” The ultimate betrayal: Elon got zero equity. Not a single share. He funded it. He built the foundation. He got nothing while they turned his non-profit into their personal cash cow This is the level of betrayal and hypocrisy we’re dealing with And for the record.... this lawsuit doesn’t put a single penny in Elon’s pocket. Any win goes straight back to the non-profit to restore the exact mission he founded

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Brian Wrobs
Brian Wrobs@brianwro·
@MikeH3110 Not sure why you are focused on this but if you are actually curious, market manipulation just like on most days prior to approval. This will happen until approval happens. Volume can be outsized, manipulation takes SP down. Not hard to understand once you understand markets.
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MikeH31
MikeH31@MikeH3110·
So up 17% and now down 3%. What do all the pumpers have to say about this piece of shit now? $nwbo
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Brian Wrobs
Brian Wrobs@brianwro·
@TheDapperDO All very true or likely so. I look at it every day as a gift. It takes lack of intelligence on the other side to help create opportunity on the right side. Every day the stock sits in a great buying zone is a gift we will never see again in our lifetimes.
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The Dapper DO
The Dapper DO@TheDapperDO·
The Psychology of Selling #NWBO I am not an expert investor. I am not a financial or technical analyst. I admit that I don’t have much credibility to offer when it comes to investing, and I wouldn’t encourage anyone to cling to my personal opinion or strategy. But I AM a Physician that knows medicine. And what I know is that DC Vax is simply extraordinary. I know that we are on the cusp of unleashing a therapy to the world that sounds like something written in science fiction, a treatment that I would doubt could even exist if I had heard about it 20 years ago… and yet, here we are. Allegedly, some nefarious characters have driven its “value” to a mere $00.20, and there seem to be a plethora of supposed non-invested parties that skirt the edge of an opinion, issue vague, non-descriptive statements about its efficacy or management, and criticize the medicine or the company trying to bring it to the public. I would bet my last dollar that those same people would give their own right arms to have if they or their family members were ever diagnosed with cancer. I believe it is worth a whole lot more than that. I believe that we are starting to see things heating up. They say a watched pot never boils, but we all know that given enough time, it does. And I believe it’s going to boil fast and overflow. “They” want you to believe that seeing the share price go to $1.00 is a miracle, that $2.00 is TEN times what the price is now! What a bargain! I think “they” believe we are gullible fools, and there are plenty of non-invested parties apparently trying to protect you from how you spend your own money. What does it mean to hold on? It means that you stop and think about what this treatment is truly worth to the millions of people whose lives may soon depend on it, whose families are already scraping together every penny they can to try to obtain it for their loved ones, and whose progress was almost destroyed (allegedly) by corporate greed and avarice. Of course, this is all just my opinion. It is definitely not investment advice. But I believe in the medicine, and I believe that selling anything soon is playing right into the hands that tried to take it all away from the patients that deserve it.
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Brian Wrobs
Brian Wrobs@brianwro·
$NWBO it’s crazy to me what the uneducated or unsophisticated will try to rationalize. Maybe I should not be surprised, but I am. It takes a little bit of understanding about drug therapy to fully appreciate the story here.
MikeH31@MikeH3110

It’s really not hard to drive down a stock when the float of shares is 1.6 billion, only 2 million shares trade per day (all bullshit retail btw), and 0 institutional buying. Anyone excited about that brief pump this morning is a sucker $nwbo

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