Caleb Lareau

The 23&me GLP1 gwas paper is very well done (the most readable gwas paper ... ever?), but I think putting this supp table 22 result in the main text would have helped keep things in perspective

New online! MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy dlvr.it/TRq6S4

MSK researchers and their collaborators have developed a new type of CAR T cell designed to target a cell surface protein called uPAR, which is found on cancer cells as well as supportive cells in the tumor microenvironment. (1/3)

@H2Colby @pronounced_kyle @Starcloud_ multi trillion is conservative tbh

@pronounced_kyle @Starcloud_ me and @CalebLareau

Request for startup: Two dudes in a garage who will someday build a multi-trillion dollar galactic empire

My opinion is that most current Bio AI models are not there yet. They suffer from lack of serious data scale and orthogonal validation, and in the absence of this, learn from many sources of systematic experimental bias. @AustinMHartman finds that off-target CRISPR guide seed effects in Perturb-seq data can quietly masquerade as real regulators. This work highlights how easy it is for these artifacts to slip through, and how valuable orthogonal validation datasets can be for building useful models in the future.

1/6 I was reanalyzing Perturb-seq data and stumbled into what I thought was a new TCR signaling regulator, only to realize it was an off-target effect. The guide ‘seed’ aligned near a canonical pathway member's TSS leading to off-target repression and association with the pathway

🚨Today in @Cancer_Cell: 50,000 tumor genomes via MSK-IMPACT. We map which HLA alleles are highest yield for antigen discovery—and define when HLA LOH constrains targetability. A framework for scaling TCR therapies. @MSKCancerCenter @parkerici authors.elsevier.com/sd/article/S15…

Dr. Ryan S. Dhindsa @RyanDhindsa has been awarded the American Brain Foundation’s @ABFbrain Cure One, Cure Many #grant to advance new ways to prevent and treat #AlzheimersDisease. @bcmhouston @TexasChildrens bcm.edu/news/bcm-resea…

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s4158… And a special shoutout to the lead author @snaga13 A 🧵

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

Pleased to share the beta release of Signac v2 today. This release makes some important changes, including support for BPCells matrices for large-scale analysis. Documentation can be found here: stuartlab.org/signac2/

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo. A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models. #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… a 🧵

In America, a serf may be let free if he picks 64 basketball games correctly

📢 We’re launching Proteina-Complexa — and after the Jensen keynote mention, we definitely had to post this thread now ;) Atomistic binder design with generative pretraining + test-time compute, plus large-scale wet-lab validation. Project page: research.nvidia.com/labs/genair/pr… 🧵 1/n

One striking example is pembrolizumab (anti-PD-1), the top-grossing mAb and overall best-selling pharmaceutical in the world. In addition to PD-1, we found that it also bound TDGF1/Cripto, and we confirmed that interaction with orthogonal assays.

The Atlantic has a sobering, first-person look at the ramifications of legalized online sports betting. Here are a few of the more telling passages. 1/5

Thrilled to share our latest study on pediatric ependymoma, out in @Nature! Biggest congratulations to all members of our international team, especially the labs of @VarunVenkatara2 and Kristian Pajtler, and fearless leader in my lab, @DaeunJeong10. @DanaFarber @BostonChildrens

Shai Gilgeous-Alexander has broken Wilt Chamberlain's all-time record with 127 consecutive games with at least 20 points.

A new mark of consistency, 63 years later 📝

Last December, @WIRED published a provocative article arguing that Parkinson's disease is driven by environmental chemicals, not genetics, and that decades of genetics research have been a dead end. I wrote about why that framing is patently wrong, and why it matters now more than ever. thecausalgene.substack.com/p/parkinsons-d…