Yu Cao

@icy_rainy_day gambler's fallacy

老冰从法国世界杯开始赌过两次世界杯。 法国世界杯最牛的成果是押中了法国队决赛4:2赢克罗地亚，131倍。 理由相当简单粗暴：所有的比分出现的概率应该相同，那么下一个比分就应该是还没有出现过的比分，所以决赛时买了双方4:2，那个常见的比分居然还没出现过，不科学嘛。 如果克罗西亚4:2赢法国的话，350倍哟😍😍😍 于是老冰成了“赌神”，卡塔尔时有位朋友来讨论日本对克罗地亚。说有人花大钱雇人的战果还不如老冰。 老冰押日本从来是2:1赢，小组赛赢了两次，这次还是押2:1，只不过是双方。 老冰真是小赌，每注只押200玩。 那位朋友说200太少了，他押2000。 2000就2000吧，也吓不死人。 后来结果是押错了唦，忘了几比几了。 再后来发现被朋友拉黑了。 这一下就想不通了：是你来找我，我只是说自己押哪个，又没劝你押，不就2000块嘛，为什么拉黑我啊？ 有位知道内情的朋友告诉我：“你的单位是块，他的单位是万块！” 他妈朋友圈里怎么混进来了个大款😂😂😂

From 4+6 to 6+6. From ER to cytoplasm. From error to destruction. Our latest paper in @CommsBio reveals how the human Derlin-1/p97 complex transitions into a hexameric channel to drive protein retrotranslocation in ERAD. #cryoEM #ERAD #proteostasis 🔗 nature.com/articles/s4200…

Thrilled to learn that the redox activity of Kvβ has proven to play a crucial role! It brings back memories of the challenges we faced in Zhou’s lab two decades ago, trying to identify its substrates and unravel the relationship between redox activities and ion channel function.

Treat🍬 or trick👻! Glycosylation is crucial for protein maturation. Our latest research on hydroxylation & dual-glycosylation processing of collagen is now published in Nature Communications! #Collagen #Glycosylation #cryoEM nature.com/articles/s4146…

Incredible work from Liang Feng's lab tackling the challenging MW limit of cryo-EM 🔬 and providing deep insights into🍬 metabolic processes. #cryoEM #Metabolism #transporter doi.org/10.1038/s41586…

Zhang and collaborators' amazing work released. The plant homolog of XPR1 shows wonderful similarity regarding the structural arrangement and function. #ionchannel nature.com/articles/s4147…

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection/permeation by a channel-like knock-kiss-kick mechanism 💻 @ciara__wallis @Riottowow tiny.cc/xpr1

Nice work by Yixiao Zhang's lab and his collaborators @corrylab. So excited to see the XPR1-KIDINS220 complex structure. #ionchannel biorxiv.org/content/10.110…

I'm very happy to announce that I have retired! I'm equally happy that @janetiwasa has agreed to continue the Molecule of the Month @buildmodels. Read about this at cdn.rcsb.org/rcsb-pdb/gener…

A concise yet comprehensive review of the latest structural and functional insights into XPR1 @NatureSMB ! It's exciting to witness the surge in phosphate channel research—and an honor to contribute to this growing field. #cryoEM #ionchannel doi.org/10.1038/s41594…

@danengw @nsmb Congratulations! Almost one-year review.

Our paper on the reaction cycle of the human dicarboxylate transporter NaDC3 finally came out in @nsmb .

@fenguita @dzine_ai @proteinimaging Elegance!

Crystal structure of the structure of domain swapped dimer of Amacstatin-2 from the hard tick Amblyomma maculatum (PDB code: 8R29) #scivis #molecularart @dzine_ai @proteinimaging behance.net/gallery/212599…

Our Structure of the yeast Ceramide Synthase is now out @NatureSMB! Thanks to all involved from @FlorianFrhlich3 and @MoellerGroup. rdcu.be/dZRn9 #cryoEM #uos

Great to see our manuscript detailing the ping-pong mechanism of human Ceramide Synthase 6 out now in @NatureSMB! An excellent collaboration between @DavidBSauer's lab @CmdOxford, Liz Carpenter, @Boehringer and @UZH_en link: doi.org/10.1038/s41594… PDF: rdcu.be/dZOJP

Join our team to explore Ca2+ signaling and unravel molecular mechanisms underlying health/disease. If you are passionate about advancing scientific discovery, apply now! #ResearchOpportunity #ScienceJobs #Postdoc #CalciumSignaling #Biochemistry jobs.uc.edu/job/Cincinnati…

Transport and InsP8 activation mechanisms of the human inorganic phosphate exporter XPR1 biorxiv.org/cgi/content/sh… #biorxiv_biophys

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR nature.com/articles/s4158…

Our paper on inositol pyrophosphate gating of the phosphate channel XPR1 is now online in @ScienceMagazine! Dive into our findings on Pi export & its regulation—key insights for understanding cellular phosphate homeostasis! #Phosphate #IonChannels science.org/doi/10.1126/sc…

Our paper on the structural basis of human collagen processing by the P3H1/CRTAP/PPIB complex has been published in @NatureComms with insights into the "face-to-face" catalytic sites for Proline modifications and transitions between trimer-hexamer states. rdcu.be/dTjDZ

Our new paper is now online! The first structural details of AE3 (SLC4A3), a key player in pH regulation of excitable cells. Dive into our cryo-EM findings to discover AE3's unique roles & sensitivity to DIDS. Congrats @Liyan_Jian @Cyzan_zai #CryoEM bit.ly/AE3paper