Chi Trader

@SaraAna66550269 @TheGregYang how longs were you on the protocol before you saw the first signs of improvement? i am 2 months in and not sure i see any. “maybe” a few subjective signs of improvement but mostly the same. thanks in advance

@TheGregYang Maraviroc and Statin worked for me. However it took approx 10 months. Not cured but functioning and out of bed. Hope it works for you!

turns out I also have a bit of long covid the covid S1 spike protein was found in my monocytes (a kind of immune cells) along with cytokine signature similar to long covid patients gonna try maraviroc + statin # the theory monocytes are like garbage cans that ingest viral debris and break it down; but for some reason the S1 protein resists breakdown instead it keeps the monocyte alive for long periods of time (months to years even) and increases its inflammatory signaling in one mechanism, these monocytes attach to capillary endothelium -> release inflammatory cytokine -> microclots form in blood vessel -> local tissue hypoxia -> more inflammation -> attracting more monocytes -> repeat this dynamics could partly explain symptoms like fatigue, brain fog, pain, autonomic issues, etc # treatment maraviroc (an HIV drug) + statin (a cholesterol drug) blocks the receptors that guide monocytes and bind them to inflamed endothelium -- when the monocytes don't feel the inflammation any more, they kill themselves safely (apoptosis), taking the S1 spike protein with them so eventually the S1-containing monocytes all die off and inflammation and symptoms mitigated, as the theory goes

@SalvMattera @TheGregYang how long were you on maraviroc before you felt improvement?

@TheGregYang x.com/i/status/20433…

@Farbod_E maybe they can create a super team with paul george and james harden and russel westbrick. combined with kawhi, if one or two get injured you still have at least 2 all star hall of famers playing

For the last month, the Clippers had plenty of chances to secure the 7th or 8th seed amid an easy (but busy) stretch to their schedule. Unfortunately, they did this to themselves with losses against the Blazers twice, Wemby-less Spurs, Kings, and Pelicans twice It is what it is

@FeelLikeOBK i thought Kawhi got you

wtf happened to Mathurin 💔

@FeelLikeOBK @joeylinn_ update?

@joeylinn_ Kawhi got us

Clippers lose. Blazers lose. LA is 41-39. Portland is 40-40. Clippers lead the season series 2-1. But if the Blazers win on Friday, they get the tiebreaker due to conference record. Very high chance this game will decide the 8th seed.

@FeelLikeOBK should have kept SGA

Blazers shot 35 free throws to the clippers 12 Can’t make this up 😂😂😂😂

@GoshawkTrades you mentioned AI. Which AI have you found to be best at this?

@resiapretorius @dbkell what would be the treatment for this? Also what would be a test I can ask my doctor to order? thanks in advance

1/7) We are excited to share our preprint, where we present a method to measure thrombo-inflammation that lead to systemic thrombotic endothelialitis in Long COVID, other post-viral and inflammatory diseases in general: biorxiv.org/content/10.648… with @dbkell and lead author Anél Thompson

@froglet80 which HIV drugs do you credit the most? I see youve tried maraviroc and saw Dr Patterson and Dr Yo. Did you use this with the astorvastatin?

I believe the latter to be instrumental in the slow but sustained progress I've made, but again - when talking about cures and recovery and whatnot - I have no intention of stopping these drugs any time soon. Because, I mean, think about it 😏

This is NOT a 'miracle cure' thread. I'll never use the word cure until we have a test, for one thing. And I've waited months to post this, because I wasn't sure. But since even the stress of the sudden move didn't set me back significantly, its time to share.

@StevenShorrock i experience the same pattern often. you have been experiencing this since 2017?

Yesterday, I felt like I was in remission. Normal energy, no headache. Today I have that poisoned, hungover, flu feeling. #MECFS

@liamsLCjourney hi what is the name of the facebook group youre referring to? is it called “bison tribe” that is the only one i have found

No matter what platform (my Reddit and Twitter polls below, also TREATME and Healthrising), Maraviroc polling always comes back around the same: - About half to a little more than half improved from maraviroc. - Half or a little less than half saw no effect. - A minority (5-10%) got worse. This makes Maraviroc one of the top interventions for Long COVID. Potential sources of bias: - the TREATME and HealthRising polls were reposted in the Patterson Protocol Facebook group -> sample bias - any intervention that works over a long time has people get better naturally - interventions that cost more, people want their investment to work out so they convince themselves they worked better than they did

@HarlingMayss @atranscendedman @SalvMattera did Dr. Patterson or someone else make the decision to continue the maraviroc/statin longer than 3 months and what was the decision based on?

@atranscendedman @SalvMattera I saw dr Bruce Patterson for 6 months. Diagnosed me with LC. He has biomarkers. After 6 months of Maraviroc/stat, he announced I don’t have LC. I said how can that make sense when I didn’t improve symptoms? No answer. Didn’t want to affect his data sets so easier to gas light.

People with Long COVID often receive one or several of the following diagnoses, sometimes in addition to, or instead of, Long COVID: -POTS -Chronic Lyme/Tick-borne infection -Mold illness/CIRS -ME/CFS -hEDS -MCAS -Fibromylagia -Vaccine injury -Many more What do all of these conditions have in common? They are poorly understood, poorly defined, poorly researched, and have no widely available tests or objective biomarkers that can be used to screen people. The symptoms are vague and heavily overlap with one another. So, with enough creativity, almost anyone can be made to fit the diagnostic criteria for any of these. (Now I know there are Lyme tests, but people dispute the validity of those. Same thing for MCAS and CIRS. POTS has a til-table, but those aren't widely available, and even then, sometimes people with POTS symptoms pass those. ME/CFS has the 2-day cpet, but no one actually does that, etc. in practice, diagnoses are just handed out based on an interview.) If you have strep throat, any doctor on the planet can swab your throat, culture it, and give you a strep throat diagnosis. But for these illnesses, it doesn't work that way. Instead, the factors that determine your diagnosis are things like: -Where you live -What doctor you see -What kind of doctor you see -What your political beliefs are -What story you are willing to tell yourself and others about the nature of your illness People who are sick and are seeking care, often cycle through these diagnosis pursuing different treatment protocols in an attempt to heal. "Oh, perhaps I have Lyme, I'll try this." When that doesn't work, they move to "maybe my house is actually infested with mold, I'll try that," and then they go "on turns out I have hEDS, I'll try these vitamins," and they go on and on for years, sometimes decades, in this cycle. It's very sad. These people are being completely screwed and left behind by mainstream medicine, which has its own basket of vague diagnoses it likes to hand out to these folks (FND, anxiety, depression). In other words, medical gaslighting. Tell the person there's nothing wrong with them; they're just crazy. But from a macro level, the issue with this system is that it is vulnerable to abuse and exploitation from people in power, and from social pressure and social conditioning. If anyone can basically receive any of these diagnoses, then people can be moved intentionally from one bucket to another, or they will be pressured to voluntarily move. I can't tell someone with cancer that they should instead identify as having diabetes, but I can convince someone with Long COVID that what they actually have is a vaccine injury. Now imagine you're a society that doesn't want to grapple with the consequences of the pandemic. The very term "long COVID" invokes the failures of the last 6 years. None of these other illnesses - ME/CFS, POTS, CIRS, etc. - do that. There's no one to blame for POTS. There's no government official to hold accountable for ME/CFS. There's no specific decision or specific statement by a specific person that anyone can point to as the reason they have CIRS. How convenient. This creates massive incentives for Long COVID to be absorbed into the broader chronic illness constellation. It means no one needs to be held responsible for letting the pandemic rip. No one has to be held accountable for the growing number of disabled people. And that's exactly what we're seeing now, in real time. The use of acronyms like IACC and PAIS in the media. People self-censoring by describing their illness as POTS rather than Long COVID. The NIH listing Long COVID as just one among several of these illnesses it's committed to studying. Groups bucketing patients from all these different illnesses into the same trials, and then using subjective endpoints so you can't tell them apart. If they get their wish, then in another year or two, there won't be any Long COVID anymore. There will just be people with ME/CFS, people with POTS, people with Chronic Lyme, etc. How do we stop this? We push for real science with real biomarkers. Figure out what's actually going on in people's bodies, and segment them into the right groups based on that. This will have the benefit of keeping the reality of the ongoing pandemic alive, and it will also ensure that we can actually find proper treatments for people.

@AnthonyIrwinLA 🤣🤣🤣

@GeneticLifehack @x3r0gx4 LDN did not work for me, does that rule out TRPM3 as a cause?

There's a tiny ion channel in your body that's involved in migraines, chronic fatigue, long Covid, and pain sensitivity — and most people have never heard of it. Meet TRPM3. 🧬 TRPM3 is a calcium ion channel that sits on your nerve cells and acts like a heat alarm. When it detects high heat — or certain neurohormones — it opens up and lets calcium flood in, which signals pain in sensory neurons. But TRPM3 doesn't just handle heat. It's also involved in: - Migraine signaling - Insulin release from the pancreas - Blood vessel constriction - Immune cell function - Glutamate balance in the brain One channel. A lot of effects. The migraine connection is fascinating — especially for women. Progesterone suppresses TRPM3. When it drops during your cycle, TRPM3 becomes more active and triggers CGRP release in the trigeminal nerve. CGRP is a key driver of migraines. This is the biological chain. Here's where it gets really interesting: #MECFS Studies show that ME/CFS patients have reduced TRPM3 function on natural killer (NK) cells. NK cells need calcium influx through TRPM3 to release the granules that kill virus-infected cells. Less TRPM3 = blunted immune response. TRPM3 also affects blood pressure response and glutamate/GABA homeostasis. The same TRPM3 dysfunction is now showing up in #longCovid patients too. Fatigue, brain fog, post-exertional malaise, pain — symptoms that overlap heavily with ME/CFS. Here's the hopeful part: a 2025 study showed that low-dose naltrexone (LDN) can restore TRPM3 function in long Covid and ME/CFS patient cells — within 24 hours. LDN blocks the mu-opioid receptor, which normally suppresses TRPM3. Remove the block, restore the function. Your genetics also matter here. Multiple variants in the TRPM3 gene are associated with increased ME/CFS risk. Others affect migraine susceptibility and pain sensitivity. Check out the full article for all the details, look at your TRPM3 variants, and see the solutions (natural and medications) that interact with TRPM3.

@RTHM_Health i have not unfortunately

That’s really frustrating, especially when you’re hoping it might help with something as limiting as PEM. It’s one of the hardest symptoms to shift, and it can be discouraging when something doesn’t make a difference. Have you found anything at all that helps even slightly with your PEM?

Have you tried Low Dose Naltrexone (LDN) for Long COVID, ME/CFS, or other chronic illness symptoms? Please share in comments. According to real-world data, 57% of RTHM Platform users who had taken LDN reported improvements, and 38% of those described the benefits as significant. The most commonly reported improvements were reduced fatigue, improved mental clarity, decreased aches and pains, and reduced post-exertional malaise. Many patients saw more noticeable benefits at the 90-day mark than after just 30 days, showing that LDN can take time to reach full effect. LDN is often started at very low doses (0.5–1.5 mg) and gradually titrated up to a tolerated dose of 3–4.5 mg. It works by modulating immune and inflammatory responses, offering support for some of the most challenging symptoms of complex chronic illness. Swipe through to see more and learn whether LDN could be a helpful part of your treatment plan. You can explore potential treatments like LDN through RTHM or join our email list for updates on research and treatment access. rthm.com #LDN #LowDoseNaltrexone #LongCOVID #MECFS #ChronicIllness #PostExertionalMalaise #ChronicFatigue

@robert65968 where and how can i get these checked?

If you are an ME/CFS patient and have not been tested for Amyloids or spike proteins you need a new doctor. Im not a physician but in 2026 I don’t think your doctor should be one either. Total cost $369. Obamacare won’t cover it. Best money you can spend. Gave my life back.

@Gmwetz @Yrrepmot when/how did it start for you? ive had it non stop for almost 5 years. It came a few months after the j&j vaccine and coincided with a month long migraine

Has anyone found a solution for their 24/7 tinnitus? Asking for me 😵‍💫

@kirstler31 @AnilvanderZee same, i would feel chills and flu like within 48hrs of exercise although a few months in someone warned me while i was mild and i stopped exercising. can you explain how your PEM felt early on in your mild days and how it is for you now?

@AnilvanderZee I exercised and went for walks every day when I first got long covid and was very mild. Then more stressors hit. Now look at me. Wish I listened to people and my body!

This is why I'm worried about exercise within limits for people with ME/PEM. I've done it when mild, worked for a while but we don't know if on the long run it will be that extra stressor that will turn on you. Did for me? Do people who don't exercise fare better? Not unlikely.

@Sabrina_Poirier if i get chills and feel like im coming down with the flu 6-48 hours after exertion but i also have dysautonomia, is that PEM? i also recover within 1-2 days

PEM is exclusive to ME. PEM is the delayed onset/delayed recovery of worsening/new symptoms, 1-3 days after exertion that is outside of our capacity. Some are calling their response PEM when they are actually having dysautonomia, MCAS or exercise intolerance. 1/