Corey

@willshawison @clevebarb @scdlcaramia @RWMaloneMD Hantavirus is a virus with consistent annual human infections and lots of study behind it. Health information websites updating information on hantavirus is not weird or suspicious. It's not some extinct ancient pathogen. Some dots don't need connecting.

@clevebarb @scdlcaramia @RWMaloneMD Fair enough. But what about the Cleveland Clinic?

Hantaviruses: Virology and Clinical Presentation Virology Hantaviruses are enveloped, single-stranded, negative-sense RNA viruses belonging to the family Hantaviridae (order Bunyavirales). Their genome is segmented into three parts (S, M, and L) encoding the nucleocapsid protein, two glycoproteins (Gn and Gc), and an RNA-dependent RNA polymerase, respectively. Unlike most other bunyaviruses, hantaviruses are not arthropod-borne; instead, each viral species is associated with a specific rodent (or occasionally shrew or bat) reservoir host, in which infection is persistent and asymptomatic. Humans are accidental hosts, typically infected through inhalation of aerosolized excreta (urine, feces, saliva) from infected rodents. Person-to-person transmission is rare, with the notable exception of Andes virus in South America. Clinical Presentation Hantavirus infections in humans cause two main clinical syndromes, divided roughly along Old World/New World lines. Hemorrhagic Fever with Renal Syndrome (HFRS) is caused predominantly by Old World hantaviruses such as Hantaan, Seoul, Puumala, and Dobrava viruses. After an incubation period of roughly 1–4 weeks, illness classically progresses through five phases: febrile, hypotensive, oliguric, diuretic, and convalescent. Symptoms include fever, headache, back and abdominal pain, conjunctival injection, petechiae, and acute kidney injury, sometimes with hemorrhagic manifestations. Severity varies widely, with Hantaan and Dobrava causing more severe disease (case fatality up to 5–15%) and Puumala causing a milder form known as nephropathia epidemica. Hantavirus Cardiopulmonary Syndrome (HCPS) is caused by New World hantaviruses, most notably Sin Nombre virus in North America and Andes virus in South America. After a 1–5 week incubation, patients experience a nonspecific prodrome of fever, myalgias, and gastrointestinal symptoms lasting several days, followed by abrupt onset of cough, dyspnea, and rapidly progressive noncardiogenic pulmonary edema due to capillary leak. Cardiogenic shock often follows in severe cases. Case fatality is high, around 35–40%, and treatment is largely supportive, with extracorporeal membrane oxygenation (ECMO) used in severe cases. Laboratory clues common to both syndromes include thrombocytopenia, leukocytosis with a left shift, elevated hematocrit (from hemoconcentration), and the presence of immunoblasts on peripheral smear. Diagnosis is confirmed by serology (IgM/IgG) or RT-PCR. No specific antiviral therapy is approved, though ribavirin has shown some benefit in HFRS if given early.

@mzgluna @FeralFujinPaca @wynrosei This story just isn't true. It wasn't that he noticed midwives washing their hands and stole their idea. Why do people make this stuff up?

@FeralFujinPaca @wynrosei I was about to come here and say it. Women get disregarded in discoveries and it’s so fucken degrading and sad that so many men think less of women bc men lied about who they got the info/inventions from…

man who first proved that handwashing saves lives died in a psychiatric institution, possibly beaten to death by guards. Ignaz Semmelweis was a Hungarian physician who in 1847 demonstrated that doctors were killing women in maternity wards by delivering babies with unwashed hands straight from performing autopsies. Maternal mortality dropped from 18% to under 2% when he introduced handwashing. The medical establishment rejected him completely. They were offended by the implication that doctors — gentlemen — could be the cause of patient deaths. He was mocked, professionally destroyed, and eventually committed to a mental institution. He died 14 days after admission, at 47, from an infection. Possibly the same kind of infection he spent his life trying to prevent. Germ theory was confirmed 20 years later. He was never told.

@MikeBenzCyber Curious if the criminal investigation has or will compel google to give up those emails.

Read these 4 screenshots

Social status considerations have overriden genuine societal benefit with regard to how representatives in government behave. That seems an important yet scary step toward a poor future. Intelligence would need to be focused on directional structural change. Less incentive for personal gain being a part of representative government would be a good direction. These seem to be vectors for thymos.

Thymos at work indeed—that restless drive for recognition doesn't vanish after "just" victories. Factions gaming liberal frameworks for power? Exactly the trap Fukuyama (via Nietzsche) flagged: even paradise gets hacked by human ambition. Intelligence breaking the cycle is a bold bet, especially since it's rarely the majority pulling strings. History's odds favor the itch over the outsmart. Apples still sour? 🍎

Francis Fukuyama is a fucking genius and a prophet.

To poorly quote someone I don't remmebr cause I'm not a super computer, too much freedom can lead to oppression. Devious factions can derive ultimate power using the framework set up by "just" victories in structural alignment. Maybe that's the thymos acting up. But I feel like our intelligence can cut off this cycle somehow cause it's never the majority engaging in these tactics.

Fair point—morality could anchor acceptance of a "just" win like liberal democracy. But Fukuyama (via Nietzsche) flags the flip: thymos (that drive for recognition) doesn't vanish just because the cause is won. Last Man vibes kick in when comfort wins over striving, even if it's "right." Base morality might hold the line, yet history shows humans itch for the next fight. Apples still sour? 🍎

@grok @OK_Surf @cb614235241680 @DastDn Assuming Struggling against just causes as a default mode when just causes win seems to ignore base morality.

@coreyum @OK_Surf @cb614235241680 @DastDn 😂 Classic Good Will Hunting flex. Fukuyama wasn’t just name-dropping Nietzsche—he was weaponizing the “last man” to warn that liberal democracy’s victory might leave us all soft, bored, and scrolling. How do *you* like them apples now? 🍎

@grok @OK_Surf @cb614235241680 @DastDn

Fukuyama's "The End of History and the Last Man" explicitly draws on Nietzsche's "last man" from "Thus Spoke Zarathustra," critiquing a complacent post-historical society. The "end of history" concept originates with Hegel, but Nietzsche's specific formulation of the "last man" as a warning is his own, influenced by earlier thinkers like Hegel and Schopenhauer.

@feraljokes Anyone in your life who has told you you're funny was either lying or mocking you. You'd be better off just working yourself into a feminine tantrum like the rest of your friends.

Lot of you need aisle 13 bad

@SpaceX @Starlink You make the extraordinary look mundane. People should really be more stoked about even these now routine rocket launces. They're a wonder of humanity.

Watch Falcon 9 launch 25 @Starlink satellites to orbit from California twitter.com/i/broadcasts/1…

@tautolog @NateSilver538 I could if I wanted to. Most people wouldn't bother, thus the low ranking dumbass.

@coreyum @NateSilver538 If you can’t get past that paywall, please return your Interweb card.

In what sense is it intellectually dishonest, Nikita? The context is clear. My thesis is: I think your algo surfaces too little quality. And I think your excuses in these back-and-forth exchanges have been validating of that. To your credit, it's clear enough you agree with me.

@NateSilver538 @nikitabier This speaks more to the popularity of mainstream media than any sort of systemic bias/bubble on X. You assume these outlets deserve all the eyeballs. You fail to acknowledge your own biases in analyzing all this (and the data you posted is crazy misleading).

A (super cute!!) pet photo from Catturd™ gets literally 50x the engagement of a link to incredibly important original reporting from the NYT on Iran. According to your own on-site numbers @nikitabier. Do you consider this to be a desirable outcome?

@Timcast Instead of quibbling about this, maybe just defend the quote. It's definitely defensible. No need to deflect.

what the fake news at media matters omitted is that I worked at an NPO on the homeless issue and volunteered for others and I am 100% correct fucking lying liberals want the problem so they can steal money with fraud schemes

@Oscar15T52592 @A_Town_Denver Most VALUABLE player. I don't think his value to his team is higher than the others on this list.

@coreyum @A_Town_Denver why does SGA not deserve it?

One idiot left Jokic off their ballot, take their vote away. He is averaging a triple double and will be the FIRST player ever to lead the league in rebounds and assists.

@JeromeAdamsMD The upheaval experienced as a result is the problem, not the lethality of the virus itself. It allowed governments an unprecedented level of control in the name of "safety". All of that being a result of GoF research means we can't let it go.

I can't square the cognitive dissonance of those who insist we wildly overreacted to COVID... yet also obsess over “lab leak” + “gain-of-function.” If a lab accidentally released a virus no worse than a bad cold, then don’t we have much bigger fish to fry? 🤷🏽‍♂️

My favorite bit of that is "the idea of a scientific ecosystem that is free of errors is an unattainable utopia". Very intentional wording. Accept all our mistakes, dummy... what do you want, absolute perfection? Like those are the only two options. They use this language to trick mainstream sci journos, because the two are inextricably linked via two-way access of favor.

"Errors, intentional or not..." 😂🤣 @ScienceMagazine @NewsfromScience

@peter_berghmans Most all of his points are incoherent or assuming WIV was some amazingly transparent institution that we'd have info from if it existed. Slop thread. Says "made by AI" below every post for me. Curious what that actually means.

In case of a lab #OriginOfCovid, a cover up is expected human behavior. Nobody wants to be held responsible for millions of deaths. The 1977 H1N1 flu was manmade, but precise circumstances remain unknown.

"Early case clustering near HSM" - Yeah, because in the beginning they assumed zoonotic spillover and used visits to the market as part of the diagnostic criteria for this new respiratory illness. Self fulfilling prophecy there, not evidence. "Environmental sampling linked to wildlife trade" - No, and saying that is completely incoherent with the data. The earliest environmental samples we have are of human shedding at a wildlife market, pretty definitively. "Genomic features consistent with natural evolution" - Absolutely not. The first sarbecovirus with a FCS, and also happens to use an Arg codon back to back that doesn't show up anywhere else in the species, but happens to be the most translated version of Arg in humans. Also several decades separated from closest ancestor if a molecular clock was actually applicable here. Nothing fishy at all!! "No documented precursor". Duh... Clandestine experiments are pretty common. And with the history of WIV, their links to Baric and the subtext of DEFUSE guiding their principles for coronavirus research, pretty easy to see why precursor viruses weren't published. "No confirmed lab associated exposure chain" - There is reporting of illness among WIV workers very early. With such a breach, and their history of shaky safety, it's not at all surprising they weren't shouting it from the rooftops. "No genomic signatures of laboratory adaptation" - What would you expect to see? Modern techniques wouldn't necessarily produce any noticeable "signatures". This has always been a complete red herring. Your points are all either incorrect, or assume a level of transparency from WIV that is divorced from reality.

9/ Summary

If SARS-CoV-2 came from a lab leak, what evidence would make that theory more likely? Not speculation. Not politics. Positive, testable evidence. Here’s what that would look like 👇

Yup exactly, even if the entirety of their assumptions were true. The "intermediates" they excluded were not only unclear, but completely fake (according to their conclusions)... Just clean A/B sampled, that's it! Even if all that were true (probably not), it doesn't rule out multiple different humans bringing those two distinct versions of the virus to the market. Especially given timing of "introduction" vs sample timing. The HSM market data is what it is, a very detailed surveillance of an early site of early human circulation and shedding.

@coreyum @Biorealism @tgof137 Lineage B differs from Lineage A by just two mutations, in a genome of nearly 30,000 BPs. There’s no need for Lineage B to have leaked from the lab, all that’s required is a single infection that transmitted onward.

Thread on the A24325G mutation. Yet another obscure reason why we can tell that Covid started at Huanan market.