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Jake Smith
145 posts
Jake Smith
@crying_EM
doing some science | using cryo-ET to study tissues in situ ❄️🔬 | @OxCellStruBio @RosFrankInst
Katılım Ekim 2019
771 Takip Edilen361 Takipçiler
@crying_EM @glynnca93 Really nice work! Excited to read in-depth.
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After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.
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it was great to share some results from mine & @glynnca93's latest preprint! It has been an interesting meeting with plenty of overlap between different imaging modalities/sample prep disciplines. Lots of insightful discussion/ideas!🔬
@VolumeEM1
Rosalind Franklin Institute@RosFrankInst
Jake Smith (@crying_EM), PhD student at the Franklin and @UniofOxford , gave a fascinating talk this afternoon about his PhD work studying the hippocampus using cryo-EM as part of the vEM Technology Forum's Cryo FIB-SEM Methods Development Session. #vEMTechForum2024 @VolumeEM1
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A huge shoutout to the rest of the team at the Franklin for making this happen.
And of course the biggest shoutout to Michael Grange (now twitter-less) for steering the ship🫡.
On to the next one 👀🧠🔬
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We hope that our structural and cell biology friends can adapt our approach to their favourite tissue biology question.
To find out more, please check out our preprint: biorxiv.org/content/10.110…
#teamtomo #LiftLaughLove
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Happy to share that our preprint on the regulation of NPC (a)symmetry is online! #teamtomo #NPC #phdlife
Wouldn't have been possible without the support of the amazing @Beck_Laboratory and great collaborators outside @svenklumpe, @MandyBoermel, @WilflingFlorian!
Beck Laboratory@Beck_Laboratory
Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
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Jake Smith retweetledi
Subtomogram averaging from lamellae
Farina Malik@duzany1care
What’s something people romanticize but it’s actually horrible?
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Jake Smith retweetledi
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!
biorxiv.org/cgi/content/sh…
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