CYN

@HenrychihangFu1 What about after a number of tec cycles you add data back or cytoxin

It’s MajesTEC-1,2,3,4,5,7,9… but I call it #MagicTec ✨🧬 An easier way to remember the journey: 🔹 Magic 1 Advanced / heavily pretreated disease 🔹 Magic 3 1st+ relapse, non-Dara refractory (teclistamab + Dara moving earlier) 🔹 Magic 4 Maintenance after transplant 🔹 Magic 5 & 7 Frontline myeloma • transplant-eligible • transplant-ineligible 🔹 Magic 9 Dara-exposed / refractory early relapse strategy What is amazing is not just the speed… but the roadmap itself. The studies are progressively moving BCMA bispecific therapy: late line → early relapse → maintenance → frontline One scientific question at a time. One indication at a time. But accumulating very, very fast. ⚡ #MultipleMyeloma ##Bispecifics #HemeTwitter

@ProfSirera What test is used to determine if the urine is removing creatine and potassium et al?

Why can someone with advanced chronic kidney disease still pass a lot of urine? At first, it seems paradoxical. We tend to imagine kidney failure as a state in which urine simply disappears. And sometimes, in very advanced disease, that is exactly what happens. But often the biology is subtler: the kidney may continue to produce urine while progressively losing the ability to produce the right urine. In advanced chronic kidney disease (CKD), excluding diabetes, high diuresis is often largely more diluted urine, but not only that. The key concept is that the damaged kidney may still produce a lot of urine while progressively losing the ability to concentrate, dilute, and regulate solute excretion efficiently. In other words: ✳️ High urine volume ≠ preserved renal function. ✳️ Diuresis is not the same as renal function. A healthy kidney does not merely eliminate water. It decides how much water should accompany sodium, urea, potassium, phosphate, acid load and thousands of soluble molecules. It concentrates urine when water must be conserved, dilutes it when water is excessive, and adjusts this balance continuously. In CKD, the number of functioning nephrons falls. The remaining nephrons are forced to excrete a larger solute load per unit. Sodium, urea, phosphate and other retained solutes still need to leave the body, and water follows solute. This can generate a form of osmotic diuresis, even without diabetes. But there is a second, crucial layer. The damaged kidney loses its concentrating machinery. Tubulointerstitial fibrosis, medullary disruption, impaired countercurrent multiplication and reduced responsiveness to vasopressin mean that the collecting duct can no longer reclaim water efficiently. The urine becomes relatively fixed around plasma osmolality: neither very concentrated nor properly diluted. This is why nocturia is often one of the early clinical clues. So yes, the urine may be abundant — but often it is more diluted, less regulated, and metabolically inefficient. A patient may pass two or three litres per day and still retain potassium, acid, phosphate or uraemic toxins. This is the central distinction: urine volume measures output, not precision. Advanced CKD is not simply a kidney that “makes less urine”. It is a kidney that progressively loses discrimination — still moving water, but no longer controlling chemistry with the elegance that health requires.

@factor_members June hogs possible double top

@Papa_Heme Are there any studies on Tec alone?

The QUINTESSENTIAL-2 study continues to enroll in the US with a control arm of Dara/pom/dex or carfilzomib/dex. How is this ethical when Dara/tec and cilta-cel are available? Close the study. This study highlights this: ashpublications.org/bloodadvances/…

@Papa_Heme Are there any studies on Tec alone?

@Papa_Heme Are there any studies on Tec alone?

@mehak_trehan What is debulking

1/ One patient. Two CAR-T targets. One very important myeloma question. 46-year-old man with heavily pretreated RRMM, diagnosed in 2017, post 2nd PBSCT, then dual BCMA–CD19 CAR-T in 2023. By 2025, he developed a striking biochemical relapse: involved kappa rose from 167.32 → 507.51 → 592.43 → 1079.07 → 3030.28 → 4267.04 within months. After debulking/bridging, he went on to receive GPRC5D-directed CAR-T. @szusmani @End_myeloma @AjaiChari @CohenAd_MMdoc @RahulBanerjeeMD @HadidiSamer @VincentRK

@icooperTrades Good time frame management

#Cocoa is up 2.6% today but struggling to get back above $3400 resistance. It never confirmed above 3400 so as I said at the time it was not a fully trustworthy breakout. This still looks a bullish chart and I remain long and looking for $4000. #commodities

@factor_members Possible double top hogs

@factor_members This breakout started Friday

@icooperTrades Dec cotton breakout

#Ethereum has been trading sideways in a similar pattern to #Bitcoin. This is technically a bull (yes, I do mean BULL) flag in the short term from the Friday 6th February green candle. BUT, the fact it is still below the $2100 after all this time is weakness in comparison to $BTC (if you see my posts on that I have a bullish bias in the short term) so I could not be long $ETH here IMO. The macro pattern on ETH (and BTC) is a bear flag and whilst below 2100 probabilities favour this drops further with $1740 being the big test below. If 1740 breaks, ETH is in trouble and whilst there is some support in the 1500-1600 region, I would expect a visit to at least 1400. BUT, I can always be wrong, and if ETH can get above 2100, the top of the parallel at 2400 is next resistance. TRANSPARENCY: I am not currently in a trade in either direction. #crypto #altcoins

@icooperTrades Good timing and good r/r set up

#Cocoa continues to get hammered and is down 5.4% today. It is now at the 2900 support level and it conitnues to look a good buy in this area. This is very oversold and there is a bull divergence on the daily RSI. I have just started a long position and looking for a move to at least $3400. NOTE: as with all positions I start. I am prepared to be wrong and will add if it drops lower. Cocoa has a lot of support between 2000-3000 (I have posted my charts about this recently) so I will DCA in and the risk reward here looks very good.

@factor_members Probably not for you but may cocoa seems like a long

@icooperTrades I figured if you trade oj you are up for illiquid. I do trade it for a swing

@cstrader66 haha, I have to say, milk just isn't one I follow. Do you trade it or just keep an eye on it?

#Bitcoin getting hammered today and down 4% as the #stockmarket and almost all assets are down. I said in the last few days, I had taken a short term long for a bounce but the bounce was much weaker than I expected and I closed that for a small loss today. I am now back short again from 75k. It looks like it will close below the $73880 support level today but won't confirm today. If it can't regain that level, 69k is next. Several months ago, I said 69k was my base case for a cycle low but as I wrote in a long post a few days ago, I have now lowered that as $BTC has dropped much faster than expected. If the #stockmarket gets the sell off I expect, I now think BTC will test 53k. But I will take it level by level and update as we go. #Crypto #Altcoins

@icooperTrades Milk did its thing

Slightly zoomed in charts to see more detail. Also, note that 69k was the high of the previous cycle

@icooperTrades Yes. A bit cleaner on interactive brokers

@cstrader66 Do you mean DC? this chart?

#USoil up 2% today and looks like it will close above $61.65. It must still confirm above, but if it does it likely gets a move up to $65. Below, there are several small resistance levels, but the next big area and buy zone is $55. #oil #Crude #Brent #WTI

@icooperTrades Futures. Da is the symbol

@cstrader66 Milk??

@drjamesdinic @revivosupps Could harm gut

@revivosupps Zero calories, zero effect on insulin and doesn’t spike blood glucose.

What does cane sugar lack that stevia has?

@dr_ericberg Fresh squeezed?

Most orange juice is pasteurized, which breaks down vitamin C. What remains is mostly sugar water, which raises blood sugar to around the levels a soda would.