Cesar Cuevas-Velazquez

My friend David Sabatini continues to be relentlessly targeted by gossip-driven tabloids pretending to be trusted scientific institutions. Science magazine’s latest piece is yet another one-sided hit job — downplaying or ignoring that the legal outcome was mixed, with some claims proceeding to trial and others moving to appellate review. I’ve spoken to dozens of his former lab members, all of whom describe him as a generous and dedicated mentor. I’ve also talked to many women who worked closely with him and never had concerns about anything resembling a sexualized work environment. Yet most remain silent. David was railroaded in a metoo-era mob campaign amplified by click-hungry reporters and social media trolls. All he’s ever wanted is to return to doing science — the work that defined his life. As long as Science and outlets like it continue pretending to be arbiters of truth while operating as gossip mills, reputations will keep being destroyed - and truth will remain secondary to spectacle. science.org/content/articl…

Functional diversity of Arabidopsis late embryogenesis abundant proteins in response to changes in the physicochemical environment biorxiv.org/content/10.110… #biorxiv_biophys

Our SUF4 condensation paper is finally out! cell.com/cell-reports/f… Thank you to everyone who has scientifically, mentally, and emotionally supported my co-authors and me over the years. Below is a summary of the work-- we hope you enjoy our findings!

I genetically engineered the amazing Arabidopsis to mimic the striking patterns of my Tradescantia zebrina🧬🌱 From concept to creation, here's the story behind transforming this plant into a living work of art! (1/7) 🧵"

TSL will miss @NeftalyCM very much. We thank him for his many, varied and valuable contributions. We wish him well for the next exciting step of his career

🏆 Estamos orgullosos de anunciar que Daiana Capdevila, jefa de nuestro @capdevilalab, es una de las ganadoras del Fondo de Innovación de @Pewtrusts 👏🏻 ¡Felicitaciones! 🔗Leé la nota completa: leloir.org.ar/capdevila-pew-…

Are you interested in the role of protein condensation in plant biology? Come work with me at Syracuse University! sujobopps.com/postings/107436

Dietary auxin may help patients to fight cancer dlvr.it/TG3KQz

📢New paper alert!! With @boothbylab @alexholehouse @fried_lab we take a look at how an entire proteome survives desiccation. TLDR: Desiccation tolerance is encoded in specific residues on the protein surface, and occurs primarily in biosynthetic enzymes. shorturl.at/U5VS1

Ok, this is a big one! Proud to present our latest story on hydropatterning-a process that allows plants to sense moisture gradients in soil and activate branching. Johannes Scharwies defines the genetic basis for this response in maize and Arabidopsis! biorxiv.org/content/10.110…

Universal cold RNA phase transitions | PNAS pnas.org/doi/10.1073/pn…

Excited to announce our latest publication from the amazing Ying Xie in @MolecularCell We find that stress granules and P-bodies fluidize the cytoplasm in response to diverse stresses. Tweetorial soon! cell.com/molecular-cell…

@Dinnenylab Congratulations, José!!!!

Dream come true! Honored and excited to take on this adventure in my scientific career. Our research on the mechanisms plants use to survive a challenging world now gets a huge boost. Thank you to my family at home and in the lab for love and support! hhmi.org/news/hhmi-inve…

After a mere blink in the cosmos -3 years as a preprint- our paper has found its home in @NatureComms . Thanks to all coauthors, the long supporting journey @Dinnenylab, and collaborators @JonikasLab and Michael Sussman. Oh, and by the way, I'm job hunting!!!

@pituvilarnadal Felicidades, Pep!!! 👏👏👏👏

Link to the paper, nature.com/articles/s4146…

Diffusing protein binders to intrinsically disordered proteins - Finetune RFdiffusion to accept secondary structure specifications along with sequence input. Add partially masked secondary structure and "block adjacency" information. - Input Target protein sequence (optionally secondary structure specification) for initial design generation, use ProteinMPNN for sequences - Evaluate, Filter and Refine designes with AF2 and FastRelax - Optimize desings with two-sided partial diffusion of both target and binder to adapt their conformations simultaneously Preprint: biorxiv.org/content/10.110…

So happy to see this epic transcriptomic, phosphoproteomic and functional genomic characterization of the osmotic stress response in Chlamydomonas with testing of conserved pathways in Arabidopsis. Phenomenal work led by @pituvilarnadal w/ @JonikasLab rdcu.be/dN0Hi

Excited to share this new collaborative chapter in our exploration of the biodiversity in environmental stress through single-cell approaches. 5 species, 3 conditions and loads of HCR validation to support findings on the evolution of gene expression. biorxiv.org/content/10.110…