Danni Gadd

Multiplex blood #proteomics using classic #MachineLearning can predict disease incidences across systems. In case you missed our previous @medrxivpreprint. medrxiv.org/content/10.110…

Case-control GWAS on 11m variants in 335k people in <4 mins using ONLY summary-level data! Check out our isGWAS @biorxivpreprint at biorxiv.org/content/10.110… - large multi GWAS now accessible to all! Made possible with @MarioniGroup @heikorunz @ZhanaKuncheva & Chris Foley!

New paper: Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2 @UoE_CGEM @EdinUni_IGC @CathyAbbottLab @dannigadd @GrantFMarshall doi.org/10.1016/j.mcn.…

Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals @RobertHillary, @dannigadd, and colleagues! Amazing paper! journals.plos.org/plosmedicine/a…

Exchange between @EdinUni_IGC and @IMBatUQ allowed collaborative genomics research by PhD students @dannigadd (@MarioniGroup) and Alesha Hatton (McRae Research Group), including utilising the @genscot dataset. ed.ac.uk/centre-genomic…

🚨New paper on epigenetic fidelity and ageing We develop a conceptual model to explain aging based on first principles and conclude that epigenetic aging is inevitable. Exciting work by @_ThomasDuffield @LivuniILCaMS + @InflamAge_UoB @UniofOxford 1/4 biorxiv.org/content/10.110…

Really proud of the latest work from Faith, @GrantFMarshall and @dannigadd. We used CRISPR to introduce a V5 tag into eEF1A2 to be able to compare expression patterns of eEF1A1 and eEF1A2 in neurons 1/4 biorxiv.org/content/10.110…

Really important paper.. a sensitive and specific biomarker for alpha-synuclein pathology is here thelancet.com/journals/laneu…

Happy to share my 1st paper, in @BiologicalPsyc1! We investigated the links between 249 circulating metabolites & Major Depressive Disorder (MDD) in @uk_biobank. A thread 🧵 of our main findings:👇

Great to join Hannah on the @EverythingEpi podcast. We discuss what DNA methylation is, the importance of the circulating proteome and how these measures were integrated in my PhD to create new markers for disease prediction. @genscot @EdinUni_IGC

Arrived in Boston for AAIC Immunity to present our multi-ancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases and the shared adaptive immune response likely mediated by HLA-DRB1*04 subtypes

New preprint from the lab. We adapt genetic correlation methodology to DNA methylation (or any 'omics data) and examine correlations between adiposity related traits. New insights to sex-specific DNA methylation associations and the epigenetic relationship between traits.

It has been fantastic to collaborate on this. For a detailed comparison of methylation vs polygenic risk scoring approaches and applications, check out our latest review @GenomeBiology.

💡 moments today. Thanks Danni from @MarioniGroup for sharing how they use @genscot data from Volunteers to predict the onset of diseases & how DNA methylation can be reversed through lifestyle changes. 💕 One more reason to become a volunteer genscot.igc.ed.ac.uk

The Lancet Commission to define risk factors for dementia is a key milestone in mapping evidence for 12 modifiable risk factors using reviews and meta-analyses. Yet, it is largely based on observational studies. What does genetic evidence tell us? Follow this 🧵to find out! 1/

We introduce a novel Multi-Response Mendelian randomization (MR2) model for the analysis of multiple related outcomes: → To account for information shared between outcomes and → To define shared or distinct causes of disease. Preprint on biorxiv.org/content/10.110… and 🧵below 1/

A Review in @NatureRevGenet discusses emerging research on the interplay of environmental pollutants with the human genome and epigenome. go.nature.com/3wQfc8S

Ultra processed foods assoc w increased risk of most cancers after 10 years finds a large longitudinal observational study of 200k UK biobank subjects. The data keeps mounting but we remain complacent... despite UK having highest rates of UPF in Europe thelancet.com/journals/eclin…

Anyone living in Scotland can sign up and be part of @genscot - a project that will advance our understanding of disease prevention. Just a saliva sample through the post and a short questionnaire!