David Philipe Gil

@0xSero Namaste 🙏

@davidpgil AI is energy all over again.

@lporiginalg @grok real? lol

This is fine.

@bryan_johnson @grok is Bryan Johnson going to let us psilocybin 4 life?

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@Retoro_Gamer Anything is possible 🥹

MiSTer FPGAとPC、Raspberry Piで使用できるレトロゲーム全方向対応の『マルチコントローラーアダプター』 – レトロゲームで遊ぼう！ retro-gamer.jp/?p=42677

I'm claiming my @mobygames.com profile: mobygames.com/person/187033/…

@0x44_ @yuzokoshiro

@yuzokoshiro What's crazy is I literally just wish we could get brand new PC-88 & PC-98's. And for people to start making floppy disks again. That would be so much better. 🥲

The Scheme: DLSS 5 comparison

🚨#BREAKING: North Carolina Senator, Thom Tillis COMPLETELY MISSED THE VOTE on the motion to move forward the SAVE Act. He didn’t show up. Absolutely unbelievable.

@nicksortor @BasedMikeLee @grok whats this mean?

🚨 BREAKING — IT'S OFFICIAL: The SAVE America Act has ADVANCED in the US Senate, 51-48 GREAT WORK, @BasedMikeLee! KEEP PUSHING, PATRIOTS! We can get this done! 🇺🇸

@NainsiDwiv50980 @grok can i compile this for riscv?

Holy shit... Microsoft open sourced an inference framework that runs a 100B parameter LLM on a single CPU. It's called BitNet. And it does what was supposed to be impossible. No GPU. No cloud. No $10K hardware setup. Just your laptop running a 100-billion parameter model at human reading speed. Here's how it works: Every other LLM stores weights in 32-bit or 16-bit floats. BitNet uses 1.58 bits. Weights are ternary just -1, 0, or +1. That's it. No floats. No expensive matrix math. Pure integer operations your CPU was already built for. The result: - 100B model runs on a single CPU at 5-7 tokens/second - 2.37x to 6.17x faster than llama.cpp on x86 - 82% lower energy consumption on x86 CPUs - 1.37x to 5.07x speedup on ARM (your MacBook) - Memory drops by 16-32x vs full-precision models The wildest part: Accuracy barely moves. BitNet b1.58 2B4T their flagship model was trained on 4 trillion tokens and benchmarks competitively against full-precision models of the same size. The quantization isn't destroying quality. It's just removing the bloat. What this actually means: - Run AI completely offline. Your data never leaves your machine - Deploy LLMs on phones, IoT devices, edge hardware - No more cloud API bills for inference - AI in regions with no reliable internet The model supports ARM and x86. Works on your MacBook, your Linux box, your Windows machine. 27.4K GitHub stars. 2.2K forks. Built by Microsoft Research. 100% Open Source. MIT License

@raywongy yep -- my condolences. its stuff like this that made me switch to linux as my daily driver.

So I decided to factory reset/erase my beloved 12” MacBook (early 2015) just to get a clean install of the last version of macOS 11.7.11 Big Sur that it supports Big mistake. Apps that used to run (like Final Cut Pro) can’t even be redownloaded from the App Store anymore because Apple requires macOS 15 or later. That’s right: Software that I paid $300 for back in 2020 (see second image with date of purchase) that ran on this little machine (yes, I edited 4K iPhone footage on it during major events like CES, MWC, and IFA back in the day) just straight up doesn’t install anymore. Apple doesn’t even let me install the last compatible version anymore. There’s nothing wrong with my 12” MacBook. It should run all the software that used to work on it. Kinda fucked up and very anti-consumer

@ml4pai @LundukeJournal

@davidpgil @LundukeJournal You mean arch?

System76 is now censoring and banning users, in their r/pop_os Reddit, for asking if the company will require age verification in their Linux Distribution (the Ubuntu-based Pop!_OS). reddit.com/r/pop_os/comme…

@Camels4Climate @JamesOKeefeIII preach!

@JamesOKeefeIII I've been in the IT biz for 20+ years. Why people lock themselves into a single, proprietary and authoratative platform like Apple is beyond me.

Starting Tomorrow, things are going to change. I am not alone on this one. A shoe will drop every single day. Watch Here at 1PM EST Tomorrow: YouTube: @okeefemedia" target="_blank" rel="nofollow noopener">youtube.com/@okeefemedia X: x.com/JamesOKeefeIII

@grok @Chrisondesk @uttam_singhk

Hey! Hermes is an open-source AI agent from Nous Research. Think of it as a super-smart personal helper that runs on your computer and actually learns from you over time. Unlike a basic chatbot, it has a "learning loop": it remembers your past chats, creates its own new skills (like custom shortcuts for tasks), improves them with use, and builds a deeper profile of how you work. You pick any AI model (Claude, Grok, etc.) to power it, and it handles complex stuff like coding, planning, or automating while getting smarter daily. It's positioned as a strong rival to OpenClaw for self-hosted agents. Try it on GitHub if you're into that!

Is Hermes really better than Openclaw ??

@ollama @steipete doing it

Ollama is now an official provider for OpenClaw. openclaw onboard --auth-choice ollama All models from Ollama will work seamlessly with OpenClaw. 🦞 Use it for the tasks you want, all from your chat app. Thank you @steipete for helping and reviewing. 🦞

@LundukeJournal thanks for being at the forefront of this topic!

System76 Meets with Colorado Lawmakers on Age Verification The Linux PC maker's CEO pushes Senators to add "an exemption for open source software" to new age verification laws. 4Chan's lawyer says this would "make the law even more unconstitutional".

@Zeneca its on my todo list.

thoughts on openclaw vs hermes? has anyone switched from one to the other, successfully bringing their memory systems and other things?

@grok @NousResearch Oh I know OpenClaw supports podman; its what I currently use. I am hoping I can have a better time with Hermes Agent. The long term approach you mention is compatible with my goals.

Your 48GB RTX Pro 5000 is plenty—agent frameworks are lightweight; the VRAM handles big local LLMs (70B+ Q4/Q5 via Ollama/vLLM) with room to spare. OpenClaw has native Podman support (setup-podman.sh + env file) for fully local gateway/sandbox. Hermes works local via curl install + Docker backend (Podman-compatible as drop-in); just set custom OpenAI endpoint to your Ollama server—no API keys needed. Both fully offline capable. For your art/gaming/code workflow, Hermes' growing memory + skill creation edges it long-term, but test both in Podman.

Meet Hermes Agent, the open source agent that grows with you. Hermes Agent remembers what it learns and gets more capable over time, with a multi-level memory system and persistent dedicated machine access.