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@discqualified69

Katılım Nisan 2023
3.2K Takip Edilen197 Takipçiler
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Learn Latin
Learn Latin@latinedisce·
Dum spīrō spērō — “While I breathe, I hope.”
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Science girl
Science girl@sciencegirl·
This is from an IBM presentation In 1979
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•|X||—@discqualified69·
God, Be with Donald Trump. May you steady his hand and sharpen his mind so that his actions mirror the sentiments of this prayer. May his words and actions help our nation while maintaining peace and prosperity with others. May you fill the gaps with your presence. IJNWP Amen.
Donald J. Trump@realDonaldTrump

Saint Michael the Archangel, defend us in battle. Be our defense against the wickedness and snares of the Devil. May God rebuke him, we humbly pray, and do thou, O Prince of the heavenly hosts, by the power of God, cast into hell Satan, and all the evil spirits, who prowl about the world seeking the ruin of souls. Amen.

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Ihtesham Ali
Ihtesham Ali@ihtesham2005·
An MIT professor taught the same math course for 62 years, and the day he retired, students from every country on earth showed up online to watch him give his final lecture. I opened the playlist at 2am and ended up watching three of them back to back. His name is Gilbert Strang. The course is MIT 18.06 Linear Algebra. Every machine learning engineer, every data scientist, every quant, every self-taught programmer who actually understands how AI works learned the math from this one man. Most of them never set foot on MIT's campus. They just opened a free playlist on YouTube and let him teach. Here's the story almost nobody tells you. Strang joined the MIT math faculty in 1962. He retired in 2023. That is 61 years of standing at the same chalkboard teaching the same subject to 18-year-olds. The interesting part is what he did when MIT launched OpenCourseWare in 2002. Most professors were skeptical. They worried that putting their lectures online would make their classrooms irrelevant. Strang did not hesitate. He said his life's mission was to open mathematics to students everywhere. He filmed every lecture and gave it away. The decision quietly changed how the world learns math. For decades linear algebra was taught the wrong way. Professors started with abstract vector spaces and proofs about field axioms. Students drowned in the abstraction. Most never recovered. They walked out believing they were bad at math when they had simply been taught in an order that nobody's brain is built to absorb. Strang inverted the entire curriculum. He started with matrix multiplication. Something you can write down on paper. Something you can compute by hand. Something you can see. Then he showed his students that everything else in linear algebra eigenvectors, singular value decomposition, orthogonality, the four fundamental subspaces was just a different lens for understanding what the matrix was actually doing under the hood. His rule was strict. If a student could not explain a concept using a concrete 3 by 3 example, that student did not actually understand the concept yet. The abstraction was supposed to come last, not first. The intuition was the foundation. The proofs were just confirmation that the intuition was correct. The second thing Strang changed was the classroom itself. He said please and thank you to his students. Every single lecture. He paused mid-derivation to ask "am I OK?" to check if anyone was lost. He never used the word "obviously" or "trivially" because he knew exactly what those words do to a student who is one step behind. He treated 19-year-olds learning math for the first time the way he treated his own colleagues. With patience. With respect. With the assumption that they belonged in the room. For 62 years. The result is something that has never happened in the history of education. A single math professor became the default teacher of his subject for the entire planet. Universities in India, China, Brazil, Nigeria, every country with a computer science department, started telling their own students to just watch Strang's lectures. The University of Illinois revised its linear algebra course to do almost no in-person lecturing. The reason was honest. The professor said they could not compete with the videos. His final lecture was in May 2023. The auditorium was packed with students who had never met him before. He walked to the chalkboard, taught for an hour, and at the end the entire room stood and applauded. He looked confused for a moment, like he genuinely did not understand why they were cheering. Then he smiled and waved them off and walked out. His written comment under the YouTube video of that final lecture was four sentences long. He said teaching had been a wonderful life. He said he was grateful to everyone who saw the importance of linear algebra. He said the movement of teaching it well would continue because it was right. That was it. No book promotion. No farewell speech. No legacy management. The man whose teaching is the foundation of modern AI just thanked the audience and went home. 20 million views. Zero ego. The entire engine of the AI revolution sits on top of math that millions of people learned for free from one quiet professor in Cambridge. The course is still on MIT OpenCourseWare. Every lecture, every problem set, every exam, every solution. Free. The most important math course of the 21st century is sitting one click away from you. Most people will never open it.
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MitohormesisClub
MitohormesisClub@MitohormesisAct·
Shining light on the abdomen — not the brain — improved Parkinson’s symptoms. “THE PRIMACY OF LIGHT: Light in shaping life” Hadza hunter-gatherers show massive seasonal swings in their gut microbiome tied to wet/dry cycles and sunlight intensity. Narrowband UVB on skin alone rapidly reshapes the gut microbiome, boosting diversity and beneficial taxa. What ties it all together? Circadian photobiology, the skin-gut axis, and mitochondrial biophysics. Parkinson’s pathology often begins in the gut years before motor symptoms — alpha-synuclein spreads via the vagus nerve. Modern indoor life severs us from natural light cycles that once sculpted resilient microbiomes and mitochondrial function. The Hadza, with near-constant equatorial sun exposure, exhibit dramatic annual microbiome cycling: certain taxa nearly disappear in the wet season (high honey) and rebound in the dry season (high fiber/meat). This flexibility supports metabolic resilience — something industrialized guts largely lost due to constant artificial light and stable diets. But diet isn’t the whole story. Skin exposure to narrowband UVB (mimicking sunlight) increases gut alpha diversity, shifts Firmicutes/Bacteroidetes ratios, enriches Lachnospiraceae and Ruminococcus (butyrate producers), and boosts taxa like Akkermansia — even without dietary changes. Vitamin D plays a role, but so do immune signaling and non-vitamin D pathways in the emerging skin-gut axis. Diurnally, natural light progression (pre-dawn infrared/red → UVA/UVB peak → evening wind-down) entrains peripheral clocks in skin, gut, and mitochondria. Artificial constant light disrupts these oscillations, altering microbial rhythms, short-chain fatty acid production, and barrier integrity. Now the photobiomodulation (PBM) link: Red/near-infrared light (670–904 nm) applied to the abdomen rescues mitochondrial function in gut cells, reduces inflammation, modulates the microbiome, and improves motor & non-motor Parkinson’s symptoms — without any direct cranial light. Animal and human data show remote (abdominal/leg) PBM provides neuroprotection comparable or superior to transcranial application in some models, likely via vagus, systemic anti-inflammatory effects, and gut-brain signaling. Mitochondria are the biophysical nexus: They contain photoacceptors (e.g., cytochrome c oxidase) tuned to red/NIR. Light enhances ATP, modulates redox, and reduces ROS. In the gut, this supports enteric neurons, microbiome balance, and vagal afferents that influence brainstem dopamine systems. Circadian misalignment in PD exacerbates mitochondrial dysfunction and gut dysbiosis. Natural diurnal/seasonal full-spectrum light (including UVB for microbiome tuning and red/NIR for mitochondrial priming) likely kept ancestral systems optimized. Abdominal PBM may partially restore this “remote” photobiological input in modern patients. We’re not saying sunlight or red light cures PD — but the data suggest light is a powerful, underappreciated environmental signal acting through mitochondria, circadian clocks, and the skin-gut-brain axis. Safe sensible sun exposure, aligned diurnal rhythms, and targeted PBM deserve rigorous study as adjuncts. Modern life is a photobiological mismatch. Reconnecting with natural light patterns — seasonally, diurnally, and therapeutically — may be key to restoring mitochondrial and microbial harmony. What do you think — is light the missing lever in chronic disease?
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Eric Topol@EricTopol

We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition @NatureMedicine nature.com/articles/s4159…

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Nicolas Hulscher, MPH
Nicolas Hulscher, MPH@NicHulscher·
🚨CANCER BREAKTHROUGH: Frog-Derived Gut Bacterium Completely ERADICATES 100% of Tumors After a SINGLE Dose in Mice A single IV dose of Ewingella americana achieved COMPLETE tumor elimination in 100% of treated mice—with NO detectable toxicity, outperforming BOTH chemo and immunotherapy. E. americana is a naturally occurring bacterium isolated from the gut microbiome of amphibians (tree frogs) and reptiles—NOT genetically engineered. In a colorectal cancer model, tumors weren’t just reduced—they were fully eliminated, with NO recurrence upon rechallenge, indicating durable immune protection. The new study found it rapidly targets tumors, multiplies inside the tumor microenvironment, and triggers a powerful immune response—activating T cells, B cells, and neutrophils for a dual attack. Investigators observed ~3,000-fold bacterial expansion within tumors within 24 hours, with NO detectable colonization in major organs. Despite IV delivery of live bacteria, there was NO significant toxicity, NO organ damage, and normal blood markers—while the bacteria cleared from circulation within 24 hours. The bacterium outperformed BOTH chemotherapy (doxorubicin, “red devil”) and immune checkpoint blockade (anti–PD-L1)—two pillars of modern cancer therapy. This represents one of the most striking preclinical cancer findings reported to date.
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Paula 💜
Paula 💜@PaulaRed62·
We are all rich with Gods love. 💜💜
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MasculineCode
MasculineCode@MasculineC20812·
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The Curious Tales
The Curious Tales@thecurioustales·
🚨BREAKING: 8 weeks of gratitude practice physically rebuilds the neural pathways between your memory and reward centers. Your brain physically rewires itself every time you feel grateful. Eight weeks of intentional gratitude practice creates measurable structural changes in the neural pathways connecting your hippocampus to your ventral tegmental area. The memory center starts talking to the reward center in a fundamentally different way. New synaptic connections form. Existing ones strengthen. The physical architecture of how you process positive experiences rebuilds itself. Most people approach gratitude like a mood they can choose to feel. A psychological vitamin they remember to take when life gets difficult. The neuroscience reveals something far more profound. Gratitude is a biological intervention that sculpts brain tissue. Researchers tracked participants practicing gratitude exercises for two months using brain scans. They watched new neural highways construct themselves in real time. The anterior cingulate cortex developed stronger connections to the medial prefrontal cortex. The brain learned to route positive emotional experiences through higher order thinking centers instead of storing them as fleeting feelings. Every positive experience you’ve ever had exists as a neural trace in your memory network. Most sit dormant, accessible only when something external triggers the specific sensory combination that originally encoded them. You smell coffee, suddenly remember a conversation from years ago. Random. Unreliable. Outside your control. Gratitude practice systematically rewires that retrieval system. After two months, participants could voluntarily access positive memories with increasing ease. Their brains had built stronger pathways between memory storage areas and emotional processing centers. They experienced deeper emotional resonance during memory retrieval. The quality of remembering itself had improved. The participants also started noticing positive details in their present environment they had previously filtered out. Their attention systems recalibrated. The same neural pathways pulling positive memories forward were scanning current experiences more thoroughly for elements worth encoding as positive memories. Their brains became biased toward collecting evidence that life contains meaningful moments. Most cognitive interventions try to change how you interpret negative experiences. Gratitude practice changes how thoroughly you notice positive ones. It teaches your visual and emotional processing systems to detect opportunities and pleasures that were always present but neurologically invisible. The timeline reveals something crucial about neural plasticity. Weeks one through three showed minimal structural changes. Participants felt slightly more positive, but brain scans looked identical to baseline. Weeks four through six showed the first measurable increases in gray matter density. Weeks seven and eight revealed entirely new neural network formation. Two months. Your nervous system can physically restructure itself with consistent practice. The method was almost embarrassingly simple. Participants wrote down three specific things they felt grateful for every evening, explaining why each mattered. No meditation apps. No guided visualizations. Just pen, paper, and the requirement to identify gratitude targets with enough detail that their brains had to actively search for positive elements. Specificity drives the neural development. General statements like “I’m grateful for my family” generate different brain activity than precise observations like “I’m grateful my daughter laughed at my terrible joke during dinner because it showed me she still finds me funny despite growing more independent.” The brain needs detailed targets to practice connecting memory specifics to emotional rewards. After eight weeks, participants developed a fundamentally different relationship with their attention and memory systems. Someone whose brain automatically scans for and emotionally amplifies aspects of experience that make existence feel worthwhile. The neural pathways remain permanent after practice ends. Gratitude carves lasting roads through consciousness.
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Darshak Rana ⚡️@thedarshakrana

Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain. Gratitude rewires the brain.

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Kait Justice ✨
Kait Justice ✨@theKaitJustice·
I wrote the most important piece of my entire life about and published it yesterday. Yes, I really do think it’s that important. May congress help us before it’s too late. #epsteinfiles
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Zachary Foster
Zachary Foster@_ZachFoster·
Israeli authorities confess they are singling out the Shi'ite Lebanese population for destruction. This is textbook ethnic cleansing, described as "Israel's message" by the @nytimes.
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GFed
GFed@GfedGoCrazy·
April fools doesn’t hit the same living in a misinformation epidemic
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ANUNNAKI🪽
ANUNNAKI🪽@Anunnaki_Creed·
HAPPY NEW YEAR🪽 EEDOKHON BREEKHA🪽
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ONENESS
ONENESS@viki5210·
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