David Nusinow

We are excited to share our analysis of over 2000 #colorectal #cancer whole #genomes from @GenomicsEngland A great collaboration with @davidcwedge @group_tomlinson @trevoragraham @AndreaSottoriva amongst many others 🧵 1/9 biorxiv.org/content/10.110…

🫡 See you on the flipside @dnusinow" target="_blank" rel="nofollow noopener">mastodon.social/@dnusinow

Thrilled to share our lab’s first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal. cell.com/cell-genomics/…

Research led by @utswcancer's @joshuagruber finds that talazoparib shrank tumors of breast cancer patients with mutations in the PALB2 gene. Nice work, Josh utsouthwestern.edu/newsroom/artic…

From sequencing and evolutionary theory we know that tumours grow as mosaics of clones - but so far we haven’t been able to see them. The labs of @Yates_lab, @MatsNilssonLab and @MoritzGerstung created a new method to map the spatial evolution of cancers: nature.com/articles/s4158…

Excited that this is out now! Thanks to @MolecularCell for including me in the `Introducing new group leaders` series! For more on our work, checkout out: schweppelab.org cell.com/molecular-cell…

Mastodon is interesting for a lot of reasons. It doesn’t feel like a real Twitter replacement but I don’t have a strong sense of what it’s really excellent for yet either. Something in between Discord/Slack/IRC and twitter somehow

It me

@spang Happy birthday!

good morning 34 ☀️🎂

Cosmically stupid or historically malicious? It's the unanswered, constantly repeating question of our time.

Everything happens so much

After watching this project come together for a while, it's great to see this out in print. Congratulations to @echouchani, @HaopengXiao, and the rest of the authors on their hard work!

#Metabolomics & computational analysis of 180 #cancer cell lines grown under the same condition identifies two major metabolic types ➡️ bit.ly/3fAsb9t @_nicola_zamboni @IMSB_ETH #metabolicflux

A big one. I've been saying for a decade: "This is biology's century." And we're still not ready. My editors asked me to explain what that means. It was harder than I expected. I hope you like reading it. statnews.com/2022/11/03/why…

Now in @JNCI_Now, Dr. Anthony T Nguyen, MD, PhD and team conduct a pan-#cancer analysis across 16 common solid tumors and find that number of positive lymph nodes is a dominant and universal predictor of mortality. Read the study here: bit.ly/3OWJyhi

babe are you ok? you’ve barely touched the dashboard you claimed was mission critical

Nature research paper: Antibody targeting of E3 ubiquitin ligases for receptor degradation #Echobox=1663788735" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

Builders 🧱 w/ Zach Sweeney - Co-Founder & CEO @ Interline Therapeutics Thanks @ZacharyKSweeney for sharing your story building @InterlineTx! See our episode below... ow.ly/qwWG50KMvqh

Most ML interpretation methods have a common enemy: Correlated features. They ruin interpretation both on a technical and a philosophical level. Why correlation is problematic, how to patch it, and why we have no cure. A thread 🧵