Dan Quiat retweetledi
Pediatric massive left ventricular hypertrophy (mLVH) is a risk factor for sudden cardiac death (SCD) and other adverse events in children with hypertrophic cardiomyopathy (HCM). ahajrnls.org/496Y6XA
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Dan Quiat
80 posts
Dan Quiat
@dquiat
Physician Scientist and Pediatric Cardiologist | Formerly @BCH_HeartCenter @HMSGenetics @HarvardMed @TheBCRP @lab_olson @UTSWmstp
Boston, MA Katılım Mart 2011
294 Takip Edilen128 Takipçiler
Dan Quiat retweetledi
Thrilled to share our research on a novel method to visualize and isolate border zone cardiomyocytes! Powerful new tool to study their contribution to heart repair and regeneration. @URMC_DeptMed #URochesterResearch
Circulation@CircAHA
Sprr1a acts a novel marker for specific subpopulation of border zone cardiomyocytes in mice, that survive myocardial infarction, facilitating their direct visualization, isolation, and longitudinal tracking. ahajrnls.org/3OmYZUW
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Dan Quiat retweetledi
In this commentary we discuss WHO needs genetic testing, WHY we need it, and HOW we can test. Genetic testing provides valuable information for our patients with HF and their families. @fatkinlab #JACCHF #Genetics #HeartFailure
JACC Journals@JACCJournals
Genetic CMPs are an under-recognized cause of #HF. Pathogenic variants: ~20% in #DCM, ~30% in HCM, & up to 45% in advanced HF, yet <2% of eligible patients undergo testing. A call to advance precision medicine in HF care? jacc.org/doi/10.1016/j.… #JACCHF #cvHCM #HeartFailure
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Dan Quiat retweetledi
Very excited to share our commentary where we discuss WHO needs genetic testing, WHY we need it, and HOW we can test (sciencedirect.com/science/articl…). Genetic testing provides valuable information for our patients with HF and their families. @fatkinlab @JACCJournals #JACCHF #Genetics
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Dan Quiat retweetledi
Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes | PNAS pnas.org/doi/10.1073/pn…
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Dan Quiat retweetledi
Excited to share our latest publication where we identified a novel and essential role of TTN enhancer. Thanks to @MerajNeyazi @KGkatzis @zoltarany @ArunSharmaPhD @ChrisToepfer @GOuditResearch @williampu66 @AxelVisel @BrighamWomens @harvardmed @bwhcvls and all others #Genetics
Journal of Clinical Investigation@jclinicalinvest
Titin, the largest known human protein, is vital for normal heart muscle contraction. @yurikim_mdphd, @MerajNeyazi & team @harvardmed now discover an intron-mediated enhancer that regulates TTN gene expression and cardiomyocyte contractility: jci.org/articles/view/…
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Dan Quiat retweetledi
Thrilled to see this collaborative effort published! Many thanks to my brilliant collaborators and mentors
Journal of Clinical Investigation@jclinicalinvest
Titin, the largest known human protein, is vital for normal heart muscle contraction. @yurikim_mdphd, @MerajNeyazi & team @harvardmed now discover an intron-mediated enhancer that regulates TTN gene expression and cardiomyocyte contractility: jci.org/articles/view/…
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Dan Quiat retweetledi
Dr. @MerajNeyazi educating us on single cell transcriptomic signatures of cardiac sarcoidosis and fantastic questions by the audience! @GOuditResearch @MartinBeyer_ @UKEHamburg @harvardmed @AHAScience @American_Heart #AHA2024 #sarcoidosis
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Dan Quiat retweetledi
Very excited to share our AHA Science Advisory where we discuss current promises and limitations of gene therapy in CVD. It was such an honor to work with @APLandstrom @SvatiShah @Joseph_C_Wu, Kricket, @AHAScience @American_Heart and @CircAHA @bwhcvls @BrighamWomens #GeneTherapy
AHA Science@AHAScience
CVD is the leading cause of 🌏 morbidity & mortality. Many are caused by damaging DNA 🧬 variants and require lifelong treatments that mitigate but do not cure disease. This advisory looks at gene therapies to treat CVD. ✍🏼: @yurikim_mdphd @APLandstrom @SvatiShah @Joseph_C_Wu
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Dan Quiat retweetledi
Just in time for #ChildhoodCancerAwarenessMonth, the Voit lab is hiring!
We looking for interested and interesting post-doc candidates to join our team @UTSWMedCenter focused at the intersection of hematopoiesis, cancer biology, and gene therapy. tinyurl.com/Voit-lab-postd…
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@RichardVoit @UTSW_PedsHemOnc @CRI_UTSW @utswcancer Congratulations @RichardVoit! UTSW is lucky to have you back. @UTSWmstp
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Next month the Voit lab will open @UTSW_PedsHemOnc @CRI_UTSW @utswcancer continuing our work studying transcriptional dysregulation in pediatric bone marrow failure and leukemia. Looking to hire at all levels, yes even level 10.
Website and official job posting coming soon.
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Dan Quiat retweetledi
The #SEQUOIA #HCM trial results are here - Placebo-controlled trial of #aficamten in #obstructive #HCM
3 presentations in 3 threads - follow along
This is the first presentation by @MartinMaronMD sharing the primary results
Follow along #CardioTwitter #HeartFailure2024
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Dan Quiat retweetledi
Acto3D: an open-source user-friendly volume rendering software for high-resolution 3D fluorescence imaging in biology
Read this Techniques and Resources Article by Naoki Takeshita, Kenta Yashiro @drkyashiro_kpum and colleagues:
journals.biologists.com/dev/article/15…
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@johnprensner @damonhofman @jruizorera @s_heesch @MolecularCell @UMich @umichmedicine @UMRogelCancer @umichrna Congratulations @johnprensner and team!
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Honored to be recognized with the @DGK_org Heart Failure Young Investigator Award for our #DeepLearning Model predicting incident HF from 1-Lead ECGs! Wearable-derived 1-lead ECGs + DL could assist in HF risk assessment in the general population tinyurl.com/3ej8v2rt
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Dan Quiat retweetledi
A major adverse effect of statins is myopathy (known since 1980). Now genetics have shed light on this association. Two independent teams have recently discovered that recessive mutations in HMGCR cause a severe form of muscular disease in humans.
A 🧵 for genetics lovers.
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Dan Quiat retweetledi
We at the CureHeart team are looking for an enthusiastic colleague to help us test and design genetic cures for inherited heart muscle diseases. We are working with human iPSCs and cutting edge CRISPR/Cas9 technologies to design these treatments. tinyurl.com/CureHeart1
GIF
Welwyn Garden City, East 🇬🇧 English
Pleased to share a new paper from the lab about the use of the muscle fusogens on vectors for therapeutic gene delivery. Huge congrats to Sajedah Hindi who did an incredible amount of work. Check it out -
authors.elsevier.com/a/1gxO4L7PXmcAg
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Dan Quiat retweetledi
In Opinion
“Today, I will explain to my healthy transplanted heart why, in what may be a matter of days or weeks at best, she — well, we — will die,” writes Amy Silverstein, an author, in a guest essay.
nyti.ms/3V0iodr
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Dan Quiat retweetledi
Excited to report our collaborative efforts to better understand mechanisms behind beneficial effects of ARB in early-stage HCM! ahajournals.org/doi/abs/10.116… Thanks to @ulvedreng @sday_hcm @HenningBundgaa1 @tikuowens @CarolynHoMD @bwhcvls @BrighamResearch and many others
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