JORGE FERNANDEZ

Cell models for investigating adipocyte differentiation and adipogenesis: a comprehensive updated review - ScienceDirect🔴✅ sciencedirect.com/science/articl…

Treatment of Anxiety for Adults in Primary Care Settings: A Review | Anxiety Disorders | JAMA Internal Medicine | JAMA Network🔴✅ jamanetwork.com/journals/jamai…

Use of GLP‐1 Analogues in Obesity and the Risk of Non‐Arteritic Ischaemic Optic Neuropathy: Let's Clarify! - Muscogiuri - 2026 - Clinical Obesity - Wiley Online Library🔴✅ onlinelibrary.wiley.com/doi/abs/10.111…

Evaluation and Management of Polycystic Ovarian Syndrome (PCOS) in Adolescents With Obesity: A Scoping Review of National and International Obesity and PCOS Management Guidelines - Lim - 2026 - Obesity Reviews - Wiley Online Library🔴✅ onlinelibrary.wiley.com/doi/abs/10.111…

Current Opinion in Lipidology🔴✅ journals.lww.com/co-lipidology/…

#PDI #PeritonealDialysis #Nephrology #ISPD #Obesity journals.sagepub.com/doi/epub/10.11… Does the Body Roundness Index (BRI), a marker of central adiposity, predict mortality and clinical outcomes in patients undergoing peritoneal dialysis?

Clinical Care for Patients With Elevated Lipoprotein(a) Level in Canada: A Practical Framework for Screening, Risk Assessment, and Management - Canadian Journal of Cardiology🔴✅ onlinecjc.ca/article/S0828-…

Postprandial glucose profiles may reflect heterogeneity in insulin secretion and sensitivity in type 2 diabetes - ScienceDirect🔴✅ sciencedirect.com/science/articl…

Graves’ disease: a new era of pathophysiology-guided therapeutics | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic🔴✅ academic.oup.com/jcem/article-a…

Beyond the Gut: thyroxine malabsorption, pharmacokinetics, and delivery | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic🔴✅ academic.oup.com/jcem/article-a…

Time to Measure Angiotensin II When Screening for Primary Aldosteronism in the Evaluation of Secondary Hypertension | Hypertension🔴✅ ahajournals.org/doi/full/10.11…

Confirmatory Testing for Primary Aldosteronism: Setting the Record Straight Under New Guidelines | Hypertension🔴✅ ahajournals.org/doi/full/10.11…

Hypercortisolism: A Prevalent and Complicating Factor in Primary Aldosteronism | Hypertension🔴✅ ahajournals.org/doi/pdf/10.116…

Beyond Spironolactone: Does Next Generation of Aldosterone Blockade Add Value? | Hypertension🔴✅ ahajournals.org/doi/full/10.11…

Resistant Hypertension Is Not Essential: It Is Primarily Aldosteronism | Hypertension🔴✅ ahajournals.org/doi/full/10.11…

Canada approves second generic version of Ozempic reut.rs/4cUzFzj reut.rs/4cUzFzj

Med News: Genetics may influence the amount of weight people lose and the adverse effects they experience with #GLP-1 medications, according to new research. ja.ma/4dn4k7p

The FDA has approved the drug Auvelity for the treatment of agitation in adults with Alzheimer's dementia. Read more:abcnews.visitlink.me/1aH3K7

$LLY's oral weight loss pill Foundayo hits 5,612 prescriptions in the third week after launch. Meanwhile, $NVO's oral Wegovy crossed 134,000 prescriptions in its 16th ‌week. $VKTX reuters.com/business/healt…

Why does cardiovascular risk of obesity persist for years despite weight loss? Why is it obesity so difficult to treat? We know the brain "defends" against weight loss via neuro-hormonal mechanisms back toward a previous state. --Adipocytes also carry memory of obesity (Hinte 2024). --So do adipose macrophages (Miranda 2025). 🆕 paper in EMBO Reports identifies long lasting memory in CD4 T cells. Researchers sequenced DNA methylation in CD4 memory T cells from mice on chow, mice on a high-fat diet, and mice that lost the weight on chow recovery. The recovery group's T cells retained characteristics of the obese phenotype: 104 genes methylated like the high-fat group, not the lean controls. Inflammatory effector memory cells stayed high through 5 weeks of weight loss. Six months of semaglutide in patients didn't shift them either. Some of the mechanisms identified: autophagy through STK26, immune senescence through CDKN1C. Palmitate stiffened the T cell membrane enough to alter receptor signalling and change DNA methylation downstream. The authors think it takes 5 to 10 years of sustained weight loss before the "methylome" resets. The inflammatory pathway is laid down long before obesity is treated and it lingers long after the scale moves. Obesity needs to be treated chronically, and we need to keep thinking of the disease in a deeper way that extends beyond weight loss itself. 🏁 doi.org/10.1038/s44319…