Dr Soaham Desai

In the phase 3 OCEANIC-STROKE trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding. Full trial results: nejm.org/doi/full/10.10… Editorial: Asundexian for Noncardioembolic Ischemic Stroke nejm.org/doi/full/10.10…

@debjani_ghosh_ Stroke is increasingly affecting the young. BE FAST BE AWARE PREVENT TREAT EARLY 90% of risk factors are modifiable with proper lifestyle @toi @TOIIndiaNews

Why this matters: Gait impairment in PD is often poorly responsive to dopamine therapy. Our findings suggest presynaptic active-zone dysfunction (Bassoon) may contribute to these symptoms — opening new avenues for: 🧬 PD genetics 🧠 synaptic biology 🚶 gait-related therapeutic

Key findings 👇 • 110 PD patients carried BSN variants (~16.5%) • BSN carriers showed higher burden of motor symptoms • FOG & shuffling gait significantly increased (OR ≈1.8) • Rare variants showed stronger association Suggests Bassoon as a potential genetic contributor

Grateful to the GOPI-YOPD & PRAI collaborators. @DrRKDhamija @drsoaham @huwmorris @SingletonNeuro @cornelisblauw @nachogenePD @MedGenomeLabs @CBR_IISc @kailashbhatia @KRayChaudhuri1 @dr_heli @MichaelJFoxOrg @Scaniitb @ANRFIndia

🧬 New paper out in European Journal of Neuroscience We report that #Bassoon (BSN) gene mutations are associated with gait dysfunction in Parkinson’s, particularly gait. Study from a 668 patient Young-Onset PD cohort across India. Read:onlinelibrary.wiley.com/doi/10.1111/ej… @movedisorder

@GuyattGH Fondly remember this paper in late 2008, when I had just finished Neurology residency at @aiims_newdelhi and Prof Kameshwar Prasad, who had taught us EBM and introduced this concept of GRADE for the first time...

Applying GRADE to #DiagnosticTests remains challenging. Here, a summary of the #GRADE approach from the days when we succeeded in being as simple and straightforward as possible. pubmed.ncbi.nlm.nih.gov/19043023/

34 Years of Excellence in Neurology

World Movement Disorders Day 2025 - What Moves You - Awareness Messages: A MDSI Initiative

@MDCP_Journal Thank you @MDCP_Journal for highlighting this important fact and our review #fnd @FNDHope @FNDHopeUK @FNDHopeUSA

Functional movement disorders aren’t ‘all in the mind’—they’re circuit-level dysfunctions! Emerging evidence shows rTMS & tDCS can help recalibrate disrupted networks, offering hope for treatment-refractory cases. Biomarkers & precision medicine are the next frontier! @drsoaham loom.ly/jx9adlE

Prof. Susanne Schneider discusses all things dystonia. Listen as she reviews the revised MDS definition and classification system for dystonia, updates for neurodegeneration with brain iron accumulation, and the exciting future of genetic therapies. loom.ly/vCw2Gko

📢Read our latest released issue! #AIAN, Volume 28, Issue 5 (Sep-Oct 2025) Available online at journals.lww.com/annalsofian/pa…

@AbhiLenka11 @GreenJournal Great case, lovely clinical reasoning, and approach to diagnosis and management 👏

For those who are interested in autonomic/autoimmune neurology, here is our recently published article in the @GreenJournal on a rare (treatable) disease. neurology.org/doi/10.1212/WN…

@MarcusVPinto @TLiewluck @GreenJournal This is a very good work and I would recommend it to all.. as the common notion is that monoclonal gammopathies are only associated with neuropathies. Here is the association of monoclonal gammopathies with myopathies.

Monoclonal gammopathy–associated myopathies are rare but treatable myopathies.
 There are four subtypes: AL amyloid myopathy, Sporadic late onset nemaline myopathy, scleromyxedema, and glycogen storage myopathy. Check out our review lead by @TLiewluck @GreenJournal.   neurology.org/doi/10.1212/WN…

@movedisorder 🇮🇳 India... 🇮🇳 India 🇮🇳 I'm so happy to see India consistently do so well in this video challenge for so many years now..

Congratulations to the winners of this year's #MDSCongress Video Challenge! Their interesting case was a unique challenge for the international experts. 1 place: Case 11 Sandeep Gurram from India 2 place: Case 14 Priyanka Samal from India 3 place: Case 15 Ayesha Hossain from USA

🧠🧬 Can a synaptic scaffolding gene explain why some Parkinson’s freeze mid-step? New data from India 🇮🇳 suggests that Bassoon (BSN) mutations may be one of the missing link in PD gait dysfunction—and even PSP overlap. 👇 Dive in. #MDSCongress #Parkinsons #Genetics EPoster-1447

Infection can be the cause of any of the most prevalent movement disorder phenotypes (as shown). A survey of clinicians by the MDS IRMD Study Group indicated that knowledge of the more well-established associations prominently contributes to diagnosis. loom.ly/QaddO5I