Eric Kelsic (he/him)

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Eric Kelsic (he/him)

Eric Kelsic (he/him)

@ekelsic

CEO & Cofounder Dyno Therapeutics (@dyno_tx): Building technology to empower patients with genetic agency

Cambridge, MA Katılım Eylül 2010
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
As #RareDiseaseWeek wraps up, I’m reflecting on how communities advance genetic medicines. Progress in rare disease therapeutic development doesn't happen in isolation. It takes researchers, technologists, physicians and patient advocates across the community working in concert to create the right treatment, show that it benefits patients, and make these medicines accessible. Today, most rare diseases patients have no available treatments that address the genetic cause of their disease. New technologies, including AI and gene therapy, are starting to change that, creating genetic agency for patients to help them live a healthier life. Last November, the inaugural Genetic Agency Technology Conference (GATC) brought 200 leaders across fields together in Boston to share their insights. This is what high-tech collaboration looks like, at scale. If you’d like to build technologies that empower patients with #GeneticAgency, we hope you join our GATC events this year. To catch more #GATC25 content or subscribe for updates, check out the new @Dyno_Tx YouTube Channel: @Dyno_Tx/videos" target="_blank" rel="nofollow noopener">youtube.com/@Dyno_Tx/videos
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
We tested Claude Mythos on @Dyno_Tx's take home interview challenge, in collaboration with @AnthropicAI This marks a new era for machine-guided design of biological sequences Only a decade after we first began exploring how deep neural networks could help humans better understand and engineer proteins Read more: dynotx.substack.com/p/claude-mytho…
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
Big news today from Dyno, licensing a muscle capsid to @AstellasUS . And amazing progress by the Dyno team solving gene delivery to skeletal muscle, one of gene therapy’s greatest challenges. Way back in 2021, with great foresight, Astellas bet on the power of AI innovation by partnering with Dyno. This milestone in our collaboration is especially meaningful to me because it signals how AI-designed capsids can enable more effective and potentially safer therapeutic delivery to skeletal and cardiac muscle tissues, all at lower doses than existing AAV capsids. By unlocking gene delivery for partners like Astellas, we move closer to a future where patients everywhere have access to the genetic medicines they need.
Dyno Therapeutics, Inc.@Dyno_Tx

We’re proud to announce that @AstellasUS has exercised its $15M option to license a Dyno AI-designed adeno-associated virus (AAV) capsid for skeletal muscle-targeted gene delivery, building on our 2021 collaboration agreement. This marks our second capsid license to a pharmaceutical partner, and it makes Dyno the first company to license AI-designed AAV capsids for both central nervous system (CNS) and muscle gene therapies. This milestone reflects years of platform development, validating our conviction that AI can solve the gene delivery challenge for therapeutic developers and ultimately create many good treatment options for patients. Learn more: businesswire.com/news/home/2026…

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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
Victoria Gray is a trailblazer and living proof of what genetic agency can mean. It was an honor to have her speak at GATC last year and to welcome her to the Dyno offices. Watch our sit-down: youtube.com/watch?v=oILSlL…
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YouTube
Dyno Therapeutics, Inc.@Dyno_Tx

What does it mean for genetic medicine developers to truly partner with patients? Victoria Gray, the first person to receive a CRISPR gene editing therapy for sickle cell disease and a speaker at the inaugural #GATC25, visited our office to sit down with CEO @ekelsic. They talked about genetic agency, the future of gene therapy, and why patients are essential partners in bridging the gap between scientific vision and real-world treatment options. Watch the conversation:

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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
Partnerships are core to Dyno’s mission, and our partnership with @NVIDIAHealthcare enabled us to break new ground in AI-powered therapeutic design. Thanks to @anthonycosta for spotlighting our latest release, Dyno Psi-Phi, last week at #GTC2026.
Dyno Therapeutics, Inc.@Dyno_Tx

At #GTC2026, @anthonycosta spoke about the leading edge of digital biology as a two-part story, defined by foundation models that encode what we know about biological systems at scale, and AI agents that accelerate our ability to experiment and iterate in real time. We’re proud of our ongoing collaboration with @NVIDIAHealth and to be part of a network of partners who are contributing to this story through the BioNeMo framework. Building on the La-Proteina family and integrating our core sequence design technology, we launched our Dyno Psi-Phi agentic AI suite for protein binder design. Great to see our work highlighted among so many of NVIDIA’s collaborators, who are also advancing therapeutic discovery for the patients who need it most.

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Olivia H. Scharfman
Olivia H. Scharfman@OliviaHelenS·
This is a well-researched article, and I highly encourage everyone to read it. But its final conclusions are unfounded. (1/n)
owl@owl_posting

Reasons to be pessimistic (and optimistic) on the future of biosecurity owlposting.com/p/reasons-to-b… "It was such a fun read (if you can say that about an article on weapons)!" —a glowing review from an early reader this is (once again) the longest article I have ever published at 13,000 words. it involves interviews with 16+ researchers/VC's/policy folks in this field, and discusses basically every single facet of biosecurity that i could find. topics include: how machine-learning in rapid response therapeutic design may work, the financial status of the customer base of biosecurity startups, why agroterrorism feels extremely likely to me, and a lot more i admittedly started the essay pessimistic that this subject matters at all, and i end it surprised that it doesn't keep more people awake at night. im not a doomer about it all, but i can see how people become one. very grateful to the people who decide to spend their career (or some fraction of it) working here, and especially grateful to the ones who helped teach me about the subject

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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
Proud of our team at @DynoTx for launching Dyno Psi-Phi at #NVIDIAGTC. Built with our partners at @NVIDIA, this open-weight model for protein design and agentic platform for sequence filtering bridges from computational predictions to real-world experimental outcomes. Together these tools help shape a future with better medicines for the patients who need them most.
Dyno Therapeutics, Inc.@Dyno_Tx

Today at #NVIDIAGTC, we announced the launch of Dyno Psi-Phi, a suite of AI-powered protein design tools developed in collaboration with @NVIDIA to help therapeutic developers create better medicines for patients everywhere. AI has made remarkable progress in generating protein sequences. But a persistent gap between computational predictions and real-world experimental outcomes has made it difficult to know which designs will actually work in the physical world, slowing the path from discovery to medicine. Dyno Psi-Phi is our answer to that challenge. The Psi-Phi suite pairs new generative models with state-of-the-art filters and accessible APIs, connecting in silico design to physical-world outcomes and putting frontier AI tools in the hands of developers across the field. Dyno Psi-1 is available through HuggingFace as an open-weight mode: huggingface.co/dynotx/dynopsi. Dyno Phi is available now at design.dynotx.com and through Claude Code. Press release: businesswire.com/news/home/2026… Blog post: dynotx.substack.com/p/dyno-psi-phi…

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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
This statement from HDSA on gene therapy for Huntington's disease - one more example of patients asking for genetic agency - more options not fewer - the chance to take action now not someday - willingness to balance the uncertain pros and cons of new treatments vs the certain cost of doing nothing
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
Hosting #GATC25 last November was the highlight of my year: gathering the world’s leading therapeutic developers, AI pioneers and patient advocates together, in one room, to co-create a future where every patient has #GeneticAgency. We could only invite 200 people to GATC, but this community is open to everyone! We just posted the conference talks to a new @Dyno_Tx YouTube channel to reach everyone who wants to learn about these rapidly advancing technologies, and their potential to enable patients everywhere to take action at the genetic level to live a healthier life. Check it out, and subscribe for genetic agency updates and conference highlights.
Dyno Therapeutics, Inc.@Dyno_Tx

We’re launching a Dyno YouTube channel to bring you closer to the science, technology, and people advancing #GeneticAgency. First up: exclusive content from our inaugural Genetic Agency Technology Conference (GATC), where we brought together therapeutic developers, technologists, AI pioneers and patient advocates to co-create the future of genetic medicine. Subscribe now → @Dyno_Tx" target="_blank" rel="nofollow noopener">youtube.com/@Dyno_Tx #GATC25

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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
@baym In cells, yes. On a computer, soon but not quite yet. Growing a plant or growing up is different from vibe coding.
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
In the future, perhaps very soon, most software will be grown
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
I spoke with @bigthink about the gene delivery challenge, @dyno_tx's AI capsid design platform, and the technologies we need to lower treatment costs and scale therapeutic development for greater patient impact. Working on these problems kept me and our team at Dyno very busy for the past decade--and while we now have the technologies to empower patients with genetic agency, we must keep at it to translate these components into effective medicines and continue to innovate so that patients everywhere will benefit. Watch here: youtube.com/watch?v=CyhqkZ…
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
@NikoMcCarty awesome list, includes many I want to check out. #14 "Can a Biologist Fix a Radio?" really influenced me back when I switched fields from physics into bio research
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Niko McCarty.
Niko McCarty.@NikoMcCarty·
Here are 30 great essays about biology. I consider these to be my "personal canon," and think that they are all basically perfect in their own ways, despite being different in form and style. All have shaped my own writing considerably. I'm not including links here, but you can easily search and find these. 1. Diagnosing the decline in pharmaceutical R&D efficiency, Jack W. Scannell et al., 2012 2. Predictive validity in drug discovery: what it is, why it matters and how to improve it, Jack Scannell et al., 2022 3. Is the cell really a machine?, Daniel J. Nicholson, 2019 4. How academia and publishing are destroying scientific innovation: a conversation with Sydney Brenner, Elizabeth Dzeng, 2014 5. A Future History of Biomedical Progress, Adam Green (Markov), 2022 6. The pharma industry from Paul Janssen to today, Alex Telford, 2023 7. The Lives of a Cell, Lewis Thomas, 1974 8. The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades, Sharon Begley, 2019 9. The Scientific Virtues, Slime Mold Time Mold, 2022 10. First Clean Water, Now Clean Air, Fin Moorhouse, 2023 11. I should have loved biology, James Somers, 2020 12. The Baffling Intelligence of a Single Cell, James Somers & Edwin Morris, 2024 13. Biology is more theoretical than physics, Jeremy Gunawardena, 2013 14. Can a biologist fix a radio?, Yuri Lazebnik, 2002 15. Cells are very fast and crowded places, Ken Shirriff, 2011 16. Life at Low Reynolds Number, E.M. Purcell, 1976 17. Lena, qntm, 2021 18. Sequences and Consequences, Sydney Brenner, 2010 19. The NIH Report, Matt Faherty, 2022 (I edited this one) 20. Simplicity in biology, Uri Alon, 2007 21. A breakthrough from 60 years ago: “General nature of the genetic code for proteins” (1961), Matthew Cobb, 2021 22. Molecular “Vitalism”, Marc Kirschner, John Gerhart, Tim Mitchison, 2000 23. The Coming Technological Singularity, Vernor Vinge, 1993 24. Review of Scientific Self-Experimentation, Brian Hanley & William Bains & George Church, 2018 25. Coming full circle-from endless complexity to simplicity and back again, Robert Weinberg, 2014 26. Nothing in Biology Makes Sense Except in the Light of Evolution, Theodosius Dobzhansky, 1973 27. The Impersonator: The Fake Data Were Coming From Inside the Lab, Uri Simonsohn, 2024 28. The Longevity FAQ, José Luis Ricón (Nintil), 2020 29. The Perfect Human is Puerto Rican, Lior Pachter, 2014 30. No Evidence of Disease, Stephanie Bourque, 2012
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
@suno Congrats and can't wait for the new tools. If you can afford it pls hire someone to add shuffle button in the mobile app
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Suno
Suno@suno·
Today we’re excited to announce our $250M Series C led by Menlo Ventures This funding enables us to accelerate what we're building: more sophisticated tools for professionals, more delightful experiences for casual creators, and new ways for people to share and connect socially through music. Most importantly, we're building an ecosystem where everyone participates together – creators, listeners, and the broader music community. suno.com/blog/series-c-…
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
This first GATC far exceeded my expectations. #GATC25 started from the idea to build a community that will empower patients everywhere with #GeneticAgency. Genetic Agency is an individual’s ability to take action at the genetic level to live a healthier life. It’s a term I started using to highlight the importance of creating more treatment options for patients, and especially medicines that address the root causes of genetic disease. What most stuck with me from GATC were the insights from patients and patient advocates such as Victoria Gray, Allyson Berent @cureangelman, and Sonia Vallabh--with a message that patients are also partners on this journey. The conversations throughout the day were candid, collaborative, and forward-looking -- aimed at identifying challenges, solutions and the potential for partnerships that will open up new therapeutic possibilities for patients. There’s still a long way to go before all patients have the gene therapies they need to live healthier lives. But I am more optimistic than ever about the promise of genetic medicines and energized to keep that momentum going through future gatherings. Thanks to everyone who attended and helped to make this first GATC so productive and so inspiring.
Eric Kelsic (he/him) tweet mediaEric Kelsic (he/him) tweet mediaEric Kelsic (he/him) tweet media
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Dyno Therapeutics, Inc.
Dyno Therapeutics, Inc.@Dyno_Tx·
Last week we held the first Genetic Agency Technology Conference (#GATC25). It was an opportunity to come together as a community of therapeutic developers, technologists, patients, and their advocates working toward a common goal of empowering patients with genetic agency – an individual’s ability to take action at the genetic level to live a healthier life. While there’s still a lot of work left to ensure that patients everywhere have the treatment options they deserve, we can make that exciting future possible through collaboration and partnership. Thank you to all who attended – looking forward to continuing this work together in meetups throughout the year, and at GATC 2026! #GeneticAgency
Dyno Therapeutics, Inc. tweet mediaDyno Therapeutics, Inc. tweet mediaDyno Therapeutics, Inc. tweet mediaDyno Therapeutics, Inc. tweet media
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Eric Kelsic (he/him)
Eric Kelsic (he/him)@ekelsic·
@ladanuzhna Congrats on the raise and all the progress. Being able epigenetically regulate any gene in the human genome is an exciting vision. And patients really need better genetic medicines. Curious what organs are you targeting and how will you deliver your therapies?
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lada
lada@ladanuzhna·
I am excited to announce what I’ve been working on for the past 2 years. General Control is a mandate to develop programmable therapies that make durable, reversible adjustments to gene expression - epigenetically activating or silencing multiple targets at once. In the past 16 months, we: - Achieved a technical leap in epigenetic editing by engineering an editor library that outperforms leading published systems on potency and durability - Launched a multi-target partnership with Novo Nordisk - Generated animal data for 3 different programs and developed a lead we are now ready to translate to the clinic - Raised 5.5M pre-seed from @age1vc @fiftyyears @tmrohan @mollyfmielke and others
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goo.vision
goo.vision@goo_vision·
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Keşfet

@Dyno_Tx @AnthropicAI @AstellasUS @anthonycosta @OliviaHelenS @DynoTx @NVIDIA @zackbshapiro