Danny

@SethSHowes @antinertia hook me up neuralink

@antinertia claude & brain is all you need

I just sequenced a human genome to 30× coverage entirely at home. As far as I know, this is the first time this has been done. I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette. Six weeks ago, I had never done wet lab biology before. I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home. Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible. I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert. For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand? To make this work, I had to navigate multiple disciplines: - writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling - learning + executing 5 hour long molecular biology protocols - building a hardware device to quantify DNA concentration Apologies for the hyperbole, but I feel super lucky to be living in 2026. A few weeks ago I decided to sequence a human genome to 30x at home. Then I actually did it. And I did it really quickly.

@artman you should actually drastically remove 99% of your featureset to get out all the slop and to make you be able to actually move fast again

Woha, sometimes I don’t know all the things we are building. This is really useful if you want the rest of the org that might not be on Linear have a direct channel to what’s happening in a project.

@BlackDirtRoad @justalexoki cambridge analytica rings a bell?

@get_exponential @justalexoki And the lemmings still dont understand why Trump and those like him gained support

dumb question maybe but wouldn't it be better to actually try to change the European Union rather than just leaving it?

@HeroToVillain0 @justalexoki look 100 years back into germanys past then you know what totalitarism really is. afd is full of holocaust deniers and they have no problem doing it again. christian lüth (afd): "we can still all put them in gas chambers if we are in power"

@get_exponential @justalexoki you are a special kinda of stupid to say that after all the problems in europe related to illegal/legal immigration and EU totalitarianism.

the cdu has not made any investments in the people or in new technologies. thats why are behind 20 years. the afds solution is to go 100 years in the past because muuuh the immigrants are taking our wealth bullshit. invest in the people, in the infrastructure instead of rich dicks

Oh you say they wanna divide. But who is putting up the Brandmauer? Who is changing the laws to make it more difficult for the opposition. Who has reigned so far and didn’t come up with any good solutions? Who is currently destroying the German economy? Can you answer these question or did mainstream media boiled your brain too much?

@oscpmentor @justalexoki what are you talking about, germany has the MOST influence😂 spreading bullshit? "too many members" yet when was the last time a new country joined??? the more people in a country the more seats they get. germany 96, malta 6 for example. can you comprehend this or too complex?

@justalexoki Too many members now for Germany to steer it in their favor. No reason for them to stay if it's causing them more pain than gain.

@anthonysheww got a server and no users, is this what you are talking about?

We tried serverless, but has anyone considered clientless?

@davidgomes have you just tried rewriting your entire codebase in rust? then you don't have to deal with this

This. Every other week pretty much.

@steipete well it works now haha

There's security, and there's clankers.

@badlogicgames jira is an abomination which must be destroyed😭😭 had to work 2 years with it at an austrian bank and they used like ALL features + multiple plugins and they had a whole team only devopsing this

recommended reading. beautifully done. seriot.ch/computation/ji…

@rezoundous cloudflare is actually overrated

Bro to bro, don't sleep on Cloudflare's stack.

@RVN256 this is a nintendo wii sir

Die Antipathie vieler Europäer gegenüber Klimaanlagen ist wirklich etwas, was ich nie verstehen werde.

@mynameisyahia they can buy me for $300M as well. would love to shitpost against openai

Anthropic buying Stainless for $300M and shutting it down just to mess with OpenAI is pretty funny What isn't funny is the fact that I now have to plan for maintaining 4 sdks.....

@badlogicgames always remember that the cake is a lie. giving me glados vibes haha

had to use violence. but the legs will be a great base for an old Android phone.

@odysseus0z @instant_db @ElectricSQL electric + trpc its magic how it streams from postgres into browsers! also let claude write custom clients for android/ios

@brodotdev @instant_db @ElectricSQL Which one did you use?

A lot of Linear's magic comes from sync engine. Linear had to built it themselves. You don't have to! There are many excellent options on the market now: Zero, @instant_db, @ElectricSQL... to name a few. Building Linear quality software is still hard, but much easier now!

@steipete a new form of autism arrives🤣

This seems more ideological than technical.

@artman thanks for the great context🥳

Lovely write up on many of the small things we’ve done to make Linear fast. Glad that someone notices the hard work that we’ve put into it.

@Schmidtlepp elon braucht einfach grade geld und scammt easy seine user weg

Twitter einfach komplettes Qualitätsmedium, ungelogen, jeder zweite Tweet in meiner TL. Was das gekostet haben muss.

Irgendjemand gibt grade richtig viel Geld aus, um diesen Tweet mit diversen Fake-Accounts in die Timeline zu drücken. Wahnsinn.