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Irisin, a hormone released by muscle during exercise, reverses obesity and insulin resistance in mice -- without cutting food intake or causing muscle loss. As a medical school professor, I find this striking. We have spent a decade asking how to mimic exercise pharmacologically. Nature Metabolism, April 2026, suggests the body already has the answer built in. Findings in high-fat-fed mice: - Irisin boosted IL-33 from stromal cells in visceral fat - Preserved ST2+ regulatory T cells (which normally collapse on HFD) - Improved obesity, glucose tolerance, energy expenditure - Browning of subcutaneous fat increased - No drop in food intake. No muscle loss. Mechanism: exercise speaks to the immune system inside fat tissue, and that conversation reverses metabolic dysfunction. Skip it -- chronic sitting, ultra-processed food -- and chronic disease accelerates. Metabolic dysfunction is the root cause of most chronic disease. Movement is the upstream lever. Full breakdown coming on the Health Longevity Secrets podcast @RobertLufkinMD" target="_blank" rel="nofollow noopener">youtube.com/@RobertLufkinMD Source: pubmed.ncbi.nlm.nih.gov/41933175/ #Irisin #Exercise #MetabolicHealth #HealthLongevitySecrets

Hay historias que inspiran de verdad. 🙌 Claudia Elena Jiménez Borchardt, orgullosamente hermosillense, ha corrido 14 maratones, entre los que destacan los 6 del World Marathon Majors, un reto que muy pocas personas en el mundo alcanzan. 🏃‍♀️ A sus 58 años, es ejemplo de disciplina y constancia. Muchas felicidades Claudia por tu gran trayectoria deportiva 👏🏼👏🏼

If your doctor checks your LDL cholesterol but not your fasting insulin, it's time for a new doctor.

Another reason to avoid sugars. This includes starches such as flour, bread, etc. Inflammation drives aging and all major chronic diseases.

#TeQuieroKino Ahhh jijo!! Pues VUELA VUELA!! Esto esta muy padre , no me había tocado un festival de papalotes 🪁🪁, y los niñ@s les encanta, todo mundo quiere tener un papalote.💯👌🏼

Stopping food intake 3 hours before bed may be one of the simplest ways to improve cardiovascular health Digestion can take roughly 5 hours, so eating too close to bedtime may interfere with the parasympathetic shift that helps blood pressure and heart rate fall during sleep In one study, people who stopped eating 3+ hours before sleep saw deeper overnight blood pressure dipping, lower heart rate, higher HRV, lower cortisol, and improved insulin sensitivity What you eat matters, but so does *when* you eat

Coming soon! magazinesdirect.com/us/single-issu…

Who pays for the American Heart Association (AHA)'s nutritional advice?

“Thank God we were canceled”: Lisa Kudrow sees the initial cancellation of “The Comeback” as a sort of blessing, which allowed her to bring back Valerie Cherish every 10 years.

Robert Therrien (1947-2019) arrived during the emerging L.A. art scene in the early 1970s and became best known for his oversized objects – tables, chairs and household fixtures that dwarf the viewer. He's now the subject of a larger-than-life exhibition currently at the Broad in Los Angeles, called "Robert Therrien: This Is a Story." cbsn.ws/3NETbWn

PARA LOS QUE APENAS SE ESTAN LEVANTANDO .... Así o más exquisito #LaSalsaDeMiAma 6622568887 Provechito dijo monchito!! Excelente sábado !! El calorcito, vaaa, estamos acostumbrados !!

I taught medical students that insulin resistance is a mystery. It's not. A new study in Science Advances just identified the molecular trigger - mitochondrial oxidative stress. Here's what they found: > Lipid overload floods mitochondria with reactive oxygen species > This blocks GLUT4 - the glucose transporter your muscles need > Result: your cells can't absorb sugar, even when insulin is screaming at them > Targeting mitochondrial oxidants improved insulin sensitivity by ~30% This is the smoking gun for Type 2 diabetes. We've spent decades blaming sugar and willpower. The real culprit is broken mitochondria - your cells' power plants drowning in metabolic waste. Fix the mitochondria, fix the insulin resistance. It's that direct. Full breakdown coming on the Health Longevity Secrets podcast. #InsulinResistance #Mitochondria #MetabolicHealth #Diabetes #Longevity Source: science.org/doi/10.1126/sc…

@historyrock_ 31 points

Singer-songwriter Don Henley says he thinks 2026 will be the end of performing for the Eagles, “and I’m OK with that.” “I don’t ever want to have a one-dimensional life,” he tells @thattracysmith. More from their conversation airs this Sunday. cbsn.ws/4r5LPKe

An exhibit at the Philadelphia Art Museum marks 100 years of surrealism, showcasing captivating paintings, sculptures and films that trace the movement's origins and its power to transport us beyond reality. Matthew Affron, the museum's curator, says the exhibit aims to push visitors outside of their comfort zones and spark curiosity. cbsn.ws/4qr7lrH

I don't believe that Diet sodas are a good health choice. For a number of reasons. h/t @drvipulaggarwal

BREAKING: A major new study just proved what I've been saying for years: Obesity and high blood pressure don't just increase risk of dementia. They *directly cause it.* This changes everything about prevention 🧵 1/ Researchers at Copenhagen used a powerful genetic analysis method (mendelian randomization) that works like a randomized trial—but using DNA. Their finding: High BMI is a DIRECT CAUSE of dementia. Not just associated. Causative. 2/ Here's the mechanism: Much of the dementia risk from obesity is driven through high blood pressure. Hypertension → vascular damage → brain damage → cognitive decline It's a cascade we can interrupt. 3/ The critical insight: Weight-loss drugs given to people who ALREADY have cognitive symptoms? No benefit. But early intervention—BEFORE symptoms appear? That's the window where prevention works. 4/ This is why I focus so much on metabolic health: Your body weight Your blood pressure Your blood sugar These aren't just heart disease markers. They're BRAIN disease markers. 5/ Actionable takeaways: ✅ Know your numbers (BMI, BP, metabolic panel) ✅ Address weight EARLY, not after problems start ✅ Treat hypertension aggressively ✅ Think of metabolic health as cognitive protection 6/ Your brain health at 80 is being determined by your choices at 50. This study proves it's not genetics or bad luck. It's physiology we can control. 🔗 sciencedaily.com/releases/2026/… What's your metabolic health strategy? More at robertlufkinmd.com

The introductions of TV shows feature some of the most memorable tunes ever written, in order to catch your attention and introduce a show's story and characters. David Pogue talks with composers Charles Fox ("Wonder Woman," "Laverne & Shirley") and Theodore Shapiro ("Severance"), and film music scholar @jonburlingame, about what makes a successful TV theme song – and how the dreaded "Skip Intro" button should be abolished. cbsn.ws/4aqU3q8

How many fewer patients would hospitals have if they began serving food that looked like this instead of the unhealthy junk food they normally serve? h/t @ifixhearts