fsmz02
2K posts

fsmz02
@fsmz02
Tech, jokes, edm, videogames, and science. Also building models for the future: Can we predict everything? 🚀🔍🎮 lately a lot of politics too, ugh.
Katılım Ağustos 2023
102 Takip Edilen72 Takipçiler
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I just sequenced a human genome to 30× coverage entirely at home.
As far as I know, this is the first time this has been done.
I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette.
Six weeks ago, I had never done wet lab biology before.
I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home.
Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible.
I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert.
For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand?
To make this work, I had to navigate multiple disciplines:
- writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling
- learning + executing 5 hour long molecular biology protocols
- building a hardware device to quantify DNA concentration
Apologies for the hyperbole, but I feel super lucky to be living in 2026.
A few weeks ago I decided to sequence a human genome to 30x at home.
Then I actually did it. And I did it really quickly.


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A female elephant sees a baby hippopotamus leave its herd and toddle off toward the lake to play. Knowing that crocodiles are lurking in the water, it tries to chase the baby hippo back to the safety of its group. 💖✨
When it meets the mother hippo, it’s basically like:
“Please keep an eye on your child, ma’am hippo.” 😔
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Florida Man + Technology = Chaos. 👍🏻
Socks on, no shoes, shirt turban on his head, MacGyver reruns in his brain.
Straps bait to a drone, flies it 200 yards out, then yanks a blacktip shark straight back to the beach like a redneck Scorpion from Mortal Kombat.
Regular Florida Man is dangerous.
Cyber Florida Man is a whole different species.
Florida stays legendary 🏖️🦈🌴
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Bro knows he only lives once
Hernan Cortes@CyberPunkCortes
There’s no food up there, and he knows there’s no food up there. He climbed up there to experience being up there.
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Qué tan borracho tienes que estar para que hasta tu propio toro diga “nah, ya fue suficiente, vámonos a casa” 😭😭
Ulises@UlisesDavid__
🚨| En Brasil, un borracho se perdió y su propio toro fue a buscarlo para llevarlo de vuelta a su casa
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