Felix Yarovinsy

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @RMedzhitov @YaleIBIO nature.com/articles/s4157…

Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses. rb.gy/lyvce8

Bacteria’s babysitter role: Indole-driven immune truce in the womb Preview of @CellCellPress work showing maternal microbiota, specifically tryptophan derivatives produced by commensals, promote maternal tolerance of the fetus to improve pregnancy outcomes cell.com/cell-host-micr…

New research involving human organoids and mice shows that crosstalk between commensal E. coli that express flagellin and intestinal epithelial cells coordinate intestinal #macrophage recruitment to support #GutBarrier homeostasis. scim.ag/4qjDMsI

⚠️ Research interrupted by 2025 funding cuts? AAI is here to help. Applications are now open for the second round of the AAI RESTORE Grants Program. We’re helping meritorious projects stay on track after unexpected grant terminations. 🔹 Who: Early-career researchers & PIs (R, K, F series, DP2/DP5, and more). 🗓️ Deadline: February 5, 2026. 💻 Apply: Log in to your AAI member account at members.aai.org/awards/aai-res…

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @J_Immunol 👇👇👇 academic.oup.com/jimmunol/artic…

Interested in immune development, placental and intestinal biology? We have two postgrad positions open in our group. Come join us.

We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ! cell.com/iscience/fullt…

Researchers developed new M1 biomarkers shared by human and mouse primary macrophages with the potential for broad applications in both basic research and clinical practice. Learn more in The JI: ow.ly/i4SG50XAb6R.

A new Nature study just mapped >16 million immune cells across 300+ people. The punchline: immune aging follows a predictable, programmable transcriptomic drift. Aging is software. Not entropy. @Molecule_sci @vitadao @BioProtocol 🔗 Paper: nature.com/articles/s4158…

In a new #CuttingEdge article researchers identified hypoxia, and the oxygen-regulated transcription factor Hypoxia-Inducible Factor 2α, as key regulators of Th2 cell differentiation and function within the small intestine. Learn more online: ow.ly/h8eG50Xt5bx.

#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved! @broz_lab @AlexandraBoegli &co show @embojournal that in intestinal epithelial cells NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion! link.springer.com/article/10.103…

Gut bacterial metabolism of steroid hormones Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability cell.com/cell-host-micr…

#WeekendRead! #EveryCellIsAnImmuneCell! Riedel Mattavelli Helal &co show @ImmunityCP that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis dlvr.it/TPCYjz

#ToPrimeOrNotToPrime, this is the question! Excited to share our new review @TrendsImmuno with Oceane in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! Free link 👇👇👇 authors.elsevier.com/sd/article/S14…

This review in The JI’s new special collection discusses the relevance of different animal species, including nontraditional models, for studying immunity in maternal-neonatal populations, shedding light on this important immune function. Read more: ow.ly/t67K50Xmt4b.

A guide to the apicomplexan cell cycle: endodyogeny and schizogony dlvr.it/TP01ss

Catalog of human oral microbiome: Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases cell.com/cell-host-micr…

Today is the deadline for Regular Abstract Submissions for IMMUNOLOGY2026™: 📅 October 22, 2025, at 6 PM ET. If you feel that you will miss today's deadline, we will open a second Regular Abstract submission period from December 2 – 16, 2025. Today is also the final day to apply for a Travel Award. Learn more: ow.ly/1yFx50XcCJ7.

I’m thrilled to be one of the co-chairs for this fantastic meeting. Join us. Submit your abstract!!!