Patrick Rodrigues

91 posts

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Patrick Rodrigues

Patrick Rodrigues

@PatFernRod

Postdoctoral Research Fellow | @TheColonnaLab | Washington University in St. Louis

St Louis, MO Katılım Mayıs 2021
266 Takip Edilen180 Takipçiler
Patrick Rodrigues retweetledi
Journal of Experimental Medicine
Journal of Experimental Medicine@JExpMed·
Fachi, Trsan, Colonna et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness & IL-22 production. LINGO4 deficiency disrupts #ILC3 function & #microbiota composition, altering susceptibility to enteric infections hubs.la/Q04dLS_k0
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Patrick Rodrigues retweetledi
The Colonna Lab
The Colonna Lab@TheColonnaLab·
Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out! doi.org/10.1084/jem.20…
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Patrick Rodrigues retweetledi
The Colonna Lab
The Colonna Lab@TheColonnaLab·
Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models. Led by Yun Chen, Alex Liu and @khainotkaiorky! doi.org/10.1126/scienc…
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Patrick Rodrigues retweetledi
The Colonna Lab
The Colonna Lab@TheColonnaLab·
Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance). science.org/eprint/EFDJ3BJ…
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Patrick Rodrigues retweetledi
Science Immunology
Science Immunology@SciImmunology·
A new Science #Immunology study pinpoints the developmental origin of a distinct group of #DendriticCells that express the transcription factor #RORγt and highlights molecular players that regulate this process. scim.ag/45vKMue
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Patrick Rodrigues retweetledi
The Colonna Lab
The Colonna Lab@TheColonnaLab·
Excited to share that our work by @PatFernRod & @TongWu99 is published: RORγt⁺ DCs are a distinct lymphoid-derived lineage whose development is controlled by REV-ERBα/β, PRDM16 and PU.1, enabling pTreg induction and protection from Th2-skewed responses. rb.gy/lyvce8
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Patrick Rodrigues retweetledi
Salva Iborra
Salva Iborra@salva_iborra·
Excited to share our new paper in @JExpMed ! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (Trm) amplify antiviral protection during reinfection. 🧵👇1/6 x.com/JExpMed/status…
Journal of Experimental Medicine@JExpMed

.@ElenaHerndezGa1, @salva_iborra and colleagues @Unicomplutense show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. hubs.la/Q03VRyd40 #MucosalImmunology

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Patrick Rodrigues retweetledi
The Nobel Prize
The Nobel Prize@NobelPrize·
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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Patrick Rodrigues retweetledi
Florian Ingelfinger
Florian Ingelfinger@FlorianIngelfi1·
🚨 New preprint! Generative modeling comes to cytometry. Meet CytoVI — a deep generative model from the @YosefLab & @IdoAmitLab for antibody-based single-cell technologies (flow, mass cytometry, CITE-seq). doi.org/10.1101/2025.0… 🧵👇
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Patrick Rodrigues retweetledi
Feiya Ou
Feiya Ou@FeiyaOu1·
🧵1/8 Happy to share my new preprint “ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.” I resolved why ID2 is essential for cDC1 lineage specification and uncovered a new paradigm of enhancers. Read here: researchsquare.com/article/rs-745…
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Patrick Rodrigues retweetledi
@realFlorentGinhoux
@realFlorentGinhoux@FGinhoux·
Happy to share our latest paper on DC ontogeny! nature.com/articles/s4159… Congratulations to the team and to Dr Zhaoyuan Liu from the Shanghai Institute of Immunology!
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Patrick Rodrigues retweetledi
Tornike Mamuladze
Tornike Mamuladze@tmamuladze·
I'm excited to share our new study published in Cell. This work uncovers a critical role for dural mast cells in shaping cerebrospinal fluid flow and protecting the brain from infection. cell.com/action/showPdf…
Jonathan Kipnis 🟦@jonykipnis

Excited to share this new work from our lab, led by an exceptional graduate student, Tornike Mamuladze (@tornikemamu), on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || authors.elsevier.com/sd/article/S00…

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Patrick Rodrigues retweetledi
Siling Du
Siling Du@DuSiling·
🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…
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Patrick Rodrigues retweetledi
The Colonna Lab
The Colonna Lab@TheColonnaLab·
Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…
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Keşfet

@NeuroCellPress @kipnislab @TheColonnaLab @ScienceMagazine @khainotkaiorky @SciImmunology @zefachi @WashU