Sean Garin

⚠️ Great work by @WebMD for highlighting #AI #Fairness challenges and opportunities and work by @UM2ii, @garin_sp and @hiti_lab, @HariTrivediMD. Lot of work ahead, but we're up for the task!

📢 Important highlight about #AI #Bias and #Fairness by our Director @PaulYiMD and 1st author @garin_sp in @NatureMedicine. Look out for more work in this area from @UM2ii coming down the pipeline!

A study from @UM2ii shows that #ArtificialIntelligence algorithms did not evaluate for inherent biases in medical imaging, meaning they have no way of knowing whether these images contain racial/ethnic representative samples of the population umaryland.edu/news/archived-…

Hot off the press: 🔥Our @UM2ii group's latest paper in @NatureMedicine showing gaps in demographic reporting in @kaggle competitions in medical imaging -- Actionable steps to improve #fairness in #AI. nature.com/articles/s4159… @Jere_Sulam @vishwa_parekh

Online today @NatureCVR, a multicenter study coordinated by the @impc, analyzes the #cardiac function and structure in ~4,000 #monogenic #knockout mice and identifies 705 mouse genes involved in cardiac function, some validated using the @uk_biobank, nature.com/articles/s4416…

KOMP Abi3-KO mice were used to study the gene’s role in Alzheimer’s Disease (AD). Abi3 was found to be a control of microglial morphology/function and LoF led to increased synaptic loss found in AD. #mousemodels #mouseresearch Authors: Simonazzi et al. twitter.com/biorxivpreprin…

#KOMP global #Panx1 KO mice were used by researchers at NYMC to determine the gene’s contribution to #seizure induction. Panx1 is part of the innexin family and an ATP release channel in the brain. #mousemodels #mouseresearch Authors: Obot et al. twitter.com/biorxivpreprin…

KOMP #Fam72a KO mice were employed to determine the gene’s role in B cell receptor CSR and SHM. The interaction with #Ung1 was found to affect the DNA repair mechanism used during diversification. #mouseresearch #mousemodels Authors: Rogier et al. twitter.com/biorxivpreprin…

Researchers at #CITIID found a unique way to utilize #IMPC data. Classes of sparce #biclustering algorithms were evaluated by their ability to simultaneously cluster genes and tissues using datasets like mouse RNA-seq. #mousemodels #mouseresearch Authors: Nicholls & Wallace

Have you checked out our new #course and #webinar yet? Check out our article 👇 to learn more about IMPC data and how it can help you. It's free! #openaccess #mousemodel #genetics mousephenotype.org/news/impc-cour…

The Human Genome Project finished in 2003 with an almost “complete” first draft of the human genome sequence. It was about 95% complete — with over 150,000 gaps of DNA left to be sequenced. Scientists are closing these gaps, with only about 100 left! bit.ly/32sAXg0

KOMP Type 1 #dopamine receptor KO mice were used to study the effects of the receptor presence on food anticipatory activity. Interestingly, mutant mice exhibited minimal FAA at the start, but slowly reached control levels. #mousemodels #mouseresearch Authors: Assali et al.

The #Lrrc26 protein and its associated voltage-gated potassium channel were found to play a role in protection against colitis in a DDS-induced mouse model, as shown in #KOMP Lccr26 KO mice. #mousemodels #mousresearch Authors: Gonzalez-Perez et al. twitter.com/biorxiv_physio…

We're excited to announce the release of our free online IMPC training course! Do you want to know more about how to use @impc data? This course has all you need to know! @EBItraining @emblebi Check it out: ebi.ac.uk/training-beta/…

Researchers have used IMPC #Frmd7 knockout mice to observe nuances in optic flow representations and encoding processes by retinal cells. #mousemodels #mouseresearch Authors: Rasmussen et al. twitter.com/biorxiv_neursc…

IMPC heterozygous (het) #Sstr2 were used to breed WT, het, and knockout mice and determine the importance of the somatostatin receptor presence on #photoreceptor generation and #neurogenic progenitors. #mousemodels #mouseresearch Authors: Weir et al. twitter.com/biorxivpreprin…

Researchers have used KOMP2 #Copb knockout mice to identify the gene’s role in #bone mass and bone strength. #mousemodels #mouseresearch Authors: Marom et al. twitter.com/biorxivpreprin…

Researchers have found #DYRK2 is required for proper skeletal development using IMPC mice. DYRK2 also plays an important role in ciliary morphology and is necessary for hedgehog pathway induction. #mousemodels #mouseresearch Authors: Morante et al. twitter.com/biorxivpreprin…

Researchers used #Fam13a knockout mice produced by #KOMP to identify the role of the protein on the control of natural killer (NK) cell #interferon gamma production and granulation. #mousemodels #mouseresearch Authors: Zeng et al. twitter.com/biorxivpreprin…