Shawn Levy

First evolving technologies session at #genomescienceUK

Excited to share this analysis of @ElemBio’s data (and their new Cloudbreak chemistry). We see accuracy advantages in Element data, especially at 20x-30x coverages and in homopolymers and repeats. Longer sequening inserts can further improve recall through hard genome regions.

@GenomixKid @GenomeInABottle A comprehensive comparison study, in collaboration with Google, will be published on bioRxiv in mid-July. Here is a preview figure comparing AVITI with NovaSeq data. HG003 was selected as it's excluded from DeepVariant training. #Genomics #NGS #AVITI”

Is it just me, or has Element been quiet recently? Still waiting to see some data/specifications on precision and SNP/INDEL calling vs Illumina. Should be pretty easy with NA12878 @GenomeInABottle

@mason_lab @PacBio @GenomeInABottle Great to see some data on the Onso platform!! Looking forward to seeing how it looks beyond a single end read and hopefully release of the data. It's an impressive start for sure!

Impressive data rolling off the new @PacBio Onso sequencer, with Q-values staying above 50 for the full length of the read with the SBB chemistry, and starting up at 55 in the beginning! From @GenomeInABottle sample HG002:

@GenomixKid @illumina @UltimaGenomics @MGI_Technology The NovaSeqX is a $1000/day instrument (5 year life, reasonable guess at service). Genomes at 100Gb based on $2/Gb or is it 125Gb/genome based on spec page listing 128 genomes per run? Surprising inconsistency for Illumina.

Why are we talking about a $200 genome? Is no-one considering overheads, DNA extraction, library prep, QC, compute and storage? Since when did @illumina start talking about 100Gb genomes? @UltimaGenomics and @MGI_Technology are in the same boat.

Random Ramblings: New Chapters and the Elements of Competition linkedin.com/pulse/new-chap… via @LinkedIn

@coregenomics @manal_mehta @JoshWarburton2 @OmicsOmicsBlog @SanDiegOmics @JuliaKarow @MGI_BGI @illumina Sequencing costs are like cell phone plans and hotels. They rarely include everything. Ultimately don't think anyone will be disappointed as long as the cost details have transparency. @MGI_BGI aimed for that at AGBT.

@genomicslab @manal_mehta @JoshWarburton2 @OmicsOmicsBlog @SanDiegOmics @JuliaKarow Shawn, surely the real world cost of a $100 genome has to be close to $100? Are @MGI_BGI going to disappoint @illumina users?

Sometimes small airports have advantages like free wifi. Sometimes they are just small airports. @FlyHSV

HudsonAlpha Genomics Lab just completed CLIA license and first 2 HiSeq X arrive this week. Huge things in 2015. Press soon.

The million dollar sequencer with the $1000 genome or the $1000 sequencer with the million dollar genome #AGBT14

MinION. For real.

Bill Frezza proves it’s easier to criticize than understand and @bioitworld proves its desperate for attention. bio-itworld.com/2013/4/3/From-…

Long overdue releases of good stuff from our lab including the sub-$1000 genome, $50 exome capture and new software. Coming soon!!

Our first New England Journal of Medicine paper was published online today. Happy to work with such a great group... fb.me/UO97NhEy

Posters and presentations galore from HudsonAlpha #AGBT. Look forward to seeing everyone there!!

Roche has announced a hostile takeover of Illumina. Suspect it will add to the excitement at #AGBT roche.com/med-cor-2012-0…

@MishaAngrist More study is underway on larger exome. Same observations continue. Agree functional data is needed for mechanism.

@MishaAngrist Fair ? but note the 679 individuals in 1000 Genomes and 150 unaffecteds screened. Note the population that was studied too.

Lucky number 7 HiSeq came online today and we are celebrating with $1,650 exomes. Contact us for details.