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@gnnaali15

Scientist, looking at the immune system during ageing

Liverpool, England Katılım Haziran 2021
138 Takip Edilen90 Takipçiler
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angel.
angel.@thevossangel·
the whole "modesty = self respect" idea is so funny to me because there are women who have their tits out on a regular basis who are celibate and have the highest standards for men, while women who do the good girl thing are in massively abusive relationships w porn addicts.
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GG@gnnaali15·
@JuliaHB1 Even Tesco workers need to claim since their salary is so low you toe rag, you work for the sun you low IQ imbecile
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Bryan Johnson
Bryan Johnson@bryan_johnson·
My plan to cure autoimmune gastritis To our knowledge, no one has ever done this to try and cure an autoimmune disease. Context: In May, I got diagnosed with autoimmune gastritis (AIG). We found it by taking a tissue biopsy of my stomach. My immune cells are confused, causing my stomach to eat itself. AIG stops your body from absorbing nutrients like iron and B12, and can eventually lead to cancer. It likely started decades ago when I was diagnosed with hypothyroidism when 21 years old. The thyroid and stomach are closely linked in your immune system. I feel fortunate that I've been taking such good care of my body for the past five years as my condition would otherwise be much more severe. Millions of people are affected by this disease and are undiagnosed. Standard of care tells you that you can’t do anything about it. That’s old fashioned. Here is how we are going to try and cure it: Step 0: find and diagnose the disease ✅ AIG is rarely caught early because symptoms are subtle. Early warnings are low iron and B12, but when hemoglobin and hematocrit look normal, doctors routinely miss it because there are no obvious signs of anemia. A standard colonoscopy won't find it either, because it only checks the lower digestive tract, not the stomach. It was only through a highly targeted stomach biopsy that we found it. Even biopsies can miss it if they don't sample the exact right spots. Most people with AIG go undiagnosed. Step 1: Map my immune system ✅ Last Thursday, I had a blood draw to isolate and decode 1 million of my immune cells. Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria. A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing one million individual immune cells allows us to read the exact pattern of the teeth on every single key. This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining. Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within. Once we know the soldier and key, we know what therapy path to pursue to shut them down. Step 2: Catch the rogue soldiers I will be getting a second biopsy from my stomach because we need to collect live tissue. We are currently planning out the logistics of getting the sample from my stomach to the lab. We need these live cells because the initial blood tests showed the antibodies, which prove that an attack is happening, but doesn’t show us the actual rogue soldier doing the damage which is a T-cell. The live sample will allow us to match the immune system mapping we did to the live T-cells. Step 3: Build an early warning system To keep an eye on the disease as we work towards a therapy, we’re building an early warning system. I'll have my blood drawn every two weeks and we’ll pair that information with wearable data to look for flare ups. This is important because the attack happens without producing symptoms that I can easily feel. Step 4: Create a “Bryan in a dish” testing model, a miniature of my immune system At the same time, we are taking a massive sample of my immune cells and deep freezing them (cryopreservation) for two reasons: a) we’ll create a living lab: using these cells to replicate my immune environment in a lab dish. This allows us to test experimental drugs and therapies on my actual live cells before putting them into my body. b) it creates a back up plan for me by preserving the raw cellular material needed for targeted rejuvenation therapies in the future. Step 5: Build precision guided therapies to end the attack Once we know who the rogue soldiers are, we will engineer a therapy designed uniquely for them. The trick is only turning off the rogue soldiers while leaving all the other healthy ones functioning as they are. For safety checks, we’ll do two test runs: 1) we’ll run the therapy through a computer model that has my biology to evaluate how my molecules interact. 2) We will take my actual cells that we froze in Step 4 and watch them interact for real. If both are successful, we’ll pursue one of four therapies: a) fix the mistake my cells are making, restoring my immune system's natural off switches b) teach the rogue cells to tolerate my stomach instead of attacking it c) design smart molecules that physically plug into the rogue cells and turn them off d) build soldiers who will track down and eliminate the rogue soldiers causing the damage
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GG@gnnaali15·
@bryan_johnson A lot of people replying to me saying scientists aren’t getting anywhere and phds mean nothing when the biomarkers Bryan uses to measure his health were all discovered by scientists with phds 😂 okay sure
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GG
GG@gnnaali15·
@bryan_johnson Your passion is nice but it’s laughable that you think you’ll cure an autoimmune disease when thousands of scientists with PhDs haven’t yet cured it 😂
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☁️
☁️@gardenofcolours·
sunset
☁️ tweet media☁️ tweet media
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x__x
x__x@bpdsins·
i’m so perverted thank god i’m a woman
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ً@artfuIchaos·
you need to learn to stay away from people who make you mean, crazy or reactive. that’s not you or who you want to be. so if they being that out of you, they’ve got to go
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GBC
GBC@GBC_Press·
JUST IN: 🇸🇪🇮🇱 Sweden has announced that it will invite all countries to join the genocide case filed by South Africa against Israel.
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𝓐 ⭑
𝓐 ⭑@ayojoestar·
Changed out the showerhead this morning, and my supervisor was EXTREMELY helpful. Supervisor photo below.
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ceolawyer
ceolawyer@ceolawyer·
Today we remember the Bosnian genocide on July 11, 1995 when Serbs executed 8000+ people including children just because they were Muslim. It’s no surprise that Israel funded the Serbian armed forces, and has become one of the biggest allies to the genocidal regime. Serbia never apologized. Bodies are still being discovered 30+ years later. And the history of Muslims being executed for their way of worship is still happening today in Gaza, Sudan, and around the world. Today, we honor our Bosnian friends and family. As a civil rights activist and attorney, I will dedicate my life to fighting against injustice. Always.
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JM News Network
JM News Network@JMNewsNetwork_·
A young girl gently wipes away her father's tears as he weeps beside the coffin of his own father, who was murdered in the Srebrenica genocide. He will be laid to rest on July 11, 2026, after his remains were finally identified. 💔🥹
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GG@gnnaali15·
@THFCHarvey18 @hangryliving Egypt don’t have elections you fucking idiot, they didn’t vote for their leader, the U.K. government sends weapons to Israel but that doesn’t mean all brits support Israel either, learn some fuckin history about the countries you know nothing about before criticising them
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Sofia Lisboa
Sofia Lisboa@sofiabhlisboa·
Atualizado
Sofia Lisboa tweet media
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El Javi 🇲🇽
El Javi 🇲🇽@Castillismo21·
Prendo la TV a cualquier hora Argentina:
El Javi 🇲🇽 tweet media
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🅓🅞🅝🅨
🅓🅞🅝🅨@Rmadonyfc_·
POV : You just realized you are getting robbed by Messi
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GG@gnnaali15·
@liamcunningham1 It went too far when they gave Trump a fucking peace prize, peace prize for what?????
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liam cunningham
liam cunningham@liamcunningham1·
The Infantino cabal has to go. Absolutely rotten to the core. The ‘Beautiful Game’ is being made a mockery of.
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