Marcos García Ochoa

@bfacedplague @simonmaechling Your argument was that it was experimental. It was wrong.

@gomiam @simonmaechling No need, I will simply continue to elect not to take the intervention for a disease that did not warrant it.

For the umpteenth time, mRNA vaccines are not gene therapy. They cannot alter your DNA.

@laurissima18 @Nopanaden @jramonfernandez Me parece que no es un tratamiento preventivo: son anticuerpos monoclonales para combatir una infección ya existente.

@Nopanaden @jramonfernandez Olé esas enfermeras que inmunizan y PREVIENEN! 👏👏👏

Ahora que estamos en mayo y es viernes os puedo decir que el impacto de nirsevimab en los ingresos en cuidados intensivos pediátricos por bronquiolitis por virus respiratorio sincitial ha sido MAGNÍFICO one more time. Los intensivistas estamos contentos. Los críos ni os cuento.

@bfacedplague @simonmaechling Oh, if you don't consider them to be actual trials, we will have to rewrite the books.

@gomiam @simonmaechling i stand corrected, but still there were very few tested. I don't consider them to be actual trials in 2013.

@Sobrasado140191 @LeeRumble71_B @BENNDER @Farmaenfurecida Literalmente no lo hace de forma general. Si meto el caniche y pongo el microondas a 50W, morirá de sed antes que del microondas.

@gomiam @LeeRumble71_B @BENNDER @Farmaenfurecida Literalmente el electromanetismo mata, te invito a meter un caniche en un microndas a ver que pasa.

Curiosidad: esto se llama “Galope de Gish”: Es una técnica que consiste en abrumar al espectador muchos datos sesgados en poco tiempo para bloquearle y anular su juicio crítico.

@Sobrasado140191 @LeeRumble71_B @BENNDER @Farmaenfurecida ¿Desde cuándo es tocar un cable "radiación"? Por cierto, las bolas de plasma de juguete tienen hasta 5000V pero una intensidad muy baja, y son seguras. Sí, también por radiación.

@gomiam @LeeRumble71_B @BENNDER @Farmaenfurecida Toca un cable de alta tension de 50.000voltios que trabaje a 2Hz, a ver que pasa... Los Hz bajos no te van a proteger de una muerte segura, el electromanetismo no es seguridad, si es potencialmente mortal

@bfacedplague @simonmaechling "There was no human testing using mRNA until 2017". While I was wrong about the phase, human trials for mRNA vaccines against reviews started in 2013, ending successfully in 2017 with the end of phase III. Once again, how much longer term would be needed?

@gomiam @simonmaechling They were experimental. There was no human testing using mRNA until 2017 and that was a small amount of people in regards to the rabies "vaccine." Studies on long term/side effects were never conducted. They certainly are now.

@secondorderfx @simonmaechling That's not "routinely" though: viruses need to carry specific molecules for their DNA into the nucleus, lipofection doesn't cross the nuclear membrane.

@gomiam @simonmaechling External DNA enters nuclei routinely. That's how lipofection, AAV, and adenoviral vectors work. All of gene therapy. The plasmid contamination here is encapsulated in the same LNPs designed for cellular delivery. The LNP doesn't discriminate.

@secondorderfx @simonmaechling External DNA doesn't get into the nucleus but on extreme conditions.

This is the only fair critique of Aldén specifically. Huh7 cells aren't normal hepatocytes. Doesn't address: residual plasmid DNA in vials at 36-627x FDA limits (multiple independent labs). That's manufacturing residue, not mRNA. Already DNA. Integration doesn't require reverse transcription.

@MikeKnox1707 @simonmaechling Would you write or paste the definition of vaccine you agree with?

@simonmaechling They are not vaccines

@Matt_McKibbin @simonmaechling Not when it's fragmented.

@simonmaechling the SV40 can give you cancer though

@Lerianis1 @simonmaechling In vitro extreme experiments don't prove anything about reality.

@simonmaechling For the umpteenth time: YES THEY ARE. THEY HAVE PROVEN THEY CAN ALTER YOUR DNA! Remember the finding of the ALTERATIONS in LIVER CELLS from the mRNA GENE THERAPY CLOTSHOTS!

@milaakso @simonmaechling Human cells don't code for reverse transcriptases.

@simonmaechling Yes they can. They enter your cells. Reverse transcriptase is all you need for foreign genetic data to turn from RNA back to your DNA. So, if this scenario is not true, just prove me wrong. Failing that, how about stop at the umpteenth?

@CaimanVigilante @MTomasson @grok @simonmaechling You asked an AI and, when it didn't write what you wanted to read, you tried to go on a tangent. It doesn't look like you can tell anyone about understanding mRNA vaccines.

Also, you may think mrna vaccines and tampering with your proteins is a "genius" idea. Let me tell you son, if you actually understood them your view woudl actually be the contrary, this type of "vaccines", mre like injections, are one of the stupidest mos dangerous and hazardous things you can do to any mammal body. So yea, thats what you get for getting your science from CNN

@CaimanVigilante @MTomasson @grok @simonmaechling Do you even know that it won't in normal conditions and it won't enter the nucleus even in the conditions of the 2022 study?

Now look, you just came here talking about mrna vaccines cant do that because they are like all the other vaccines wich is wrong, and now you are here trying to school me on how crispr works. Chill out booaah!Did you read the above statements? do you even knew before i told you that mrna vaccine CAN and WILL reverse transcribe into the nucleous of a cell?

@Nfcanavan @simonmaechling Wrong definition sorry. Gene therapy is therapy acting on genes, not therapy using genes. Disabling genes for COPD is gene therapy, mRNA vaccines aren't.

@simonmaechling Half this statement is Incorrect. As you well know, RNA is the translated code of an DNA-based gene; when used for a therapeutic purpose it is, by definition, gene therapy. However, the second part IS true. RNA is very short-lived and does not (cannot) integrate into your genome.

@C8tetate @simonmaechling Traditional vaccines present antigens through attenuated or dead pathogens and toxins, or induce antigen production through weakened or vector viruses (conceptually closer to mRNA). Pseudo-mRNA vaccines induce antigen production without needing viral vectors.

@simonmaechling Honest, genuine question how do they actually work? What makes them different from the older vaccines? (VERY pro vax here, genuinely curious!)

@Danny66qw @fjc0000 @simonmaechling If you claim that a vaccine must provide sterilizing immunity to be called that, what is the tetanus vaccine made of?

@fjc0000 @simonmaechling No, I’m right. The mRNA shots offered no sterilizing immunity. And unfortunately, they were pushed the hardest on young folks who didn’t need them at all.

@secondorderfx @simonmaechling RT in extreme conditions, not in normal cells in normal conditions.

@simonmaechling Peer-reviewed evidence complicates this. Aldén et al. 2022 demonstrated reverse transcription of BNT162b2 mRNA into DNA in human liver cells. Plasmid DNA contamination has been independently confirmed. The honest claim is "mechanism exists, scale unknown," not "cannot."

@bfacedplague @simonmaechling They weren't experimental since they passed phase III trials. I would like to read your definition of vaccine (if you are going to post a link, cut&paste the definition). mRNA has been phase III tested since 2013. How much longer term would be needed?

@simonmaechling For the impernth time, there is a reason I call them experimental injections. They aren’t a vaccine, and no one was really sure of the long term effects.

@CotswoldsQC @Shana_Zen @simonmaechling Scientists who don't research viruses or vaccines.

@Shana_Zen @simonmaechling People who are scientists? pmc.ncbi.nlm.nih.gov/articles/PMC91…