Peggy Goodell

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Peggy Goodell

Peggy Goodell

@Goodell_Lab

The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Chair, Dept of Mol Cell Biology at Baylor College of Medicine. Tweets my own.

Houston, Texas Katılım Mart 2012
541 Takip Edilen4.7K Takipçiler
Peggy Goodell
Peggy Goodell@Goodell_Lab·
Data on factors impacting time-to-acceptance could be crowd-sourced. Major factors: - time before first editor desk decision (varies a lot by editor and journal) - review time (huge variation; also heavily influenced by the editors) - editor decision time after reviews come in (can be longer than one would think) – revision time (authors chasing very time-consuming experiments for the win; heavily influenced by (lack of) editor guidance, but also topic, model system...) - second round (all same variables) - possible appeal time (appeals are high at top journals and take even more time and can add to total time) Journals track all this data. Authors should have it too. Decent crowd-sourced data could be in ~real-time, and would help authors make informed decisions. I think many ppl would contribute data from their experience.
Sasha Gusev@SashaGusevPosts

Monthly median Received to Accepted time (days) at Nature Genetics

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Mick Milsom
Mick Milsom@MilsomMick·
First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety exphem.org/article/S0301-…
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Peggy Goodell
Peggy Goodell@Goodell_Lab·
An interesting question not addressed is the lifestyle differences of people with inactivating myostatin variants. You might guess that people with more muscle will excel in activities where those traits are valuable (e.g., athletics or certain jobs). Those activities might be self-reinforcing, further enhancing muscle growth and amplifying the apparent genetic effect over time. Lots more to learn, but a great investigation that will move the field forward. #aging #muscle #health
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Peggy Goodell
Peggy Goodell@Goodell_Lab·
It’s also a testament to the incredible societal value of these huge biobanks, the careful genotyping, thoughtful phenotyping, and mechanisms to make these available for analysis. THANK YOU to everyone who participates as a subject, to all the researchers who have worked so hard on these incredibly valuable resources, and to the funding bodies with foresight to invest in these. UKB and similar are truly transformative IMO.
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Peggy Goodell
Peggy Goodell@Goodell_Lab·
Remarkable new study showing that many individuals with genetic variants that disrupt the function of myostatin (a protein that normally inhibits muscle growth) have ⬆️muscle mass,⬇️ body fat, and ⬆️strength. Increased muscle mass is clinically desirable for #healthyaging and for countering muscle loss in various contexts (including use of #GLP1 agonists). Below, MRI images of a subject with above-average muscle mass (left) and average muscle mass (right) from the study. Congrats @davidjglassMD and colleagues! Link ⬇️
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Peggy Goodell
Peggy Goodell@Goodell_Lab·
Important work w real translational potential for cancer patients. Built on foundational science developed over years. Congrats to all!
Abdel-Wahab Lab@AbdelWahablab

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s4158…

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Yash Pershad
Yash Pershad@yash_pershad·
Excited to share that I defended my PhD in Human Genetics 🧬 I am immensely grateful to my mentor @AlexBickMDPhD, my family, my co advisor Dan Roden, my labmates, the @VanderbiltMSTP, our amazing collaborators, my committee, and everyone who has supported me!
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DrawImpacts
DrawImpacts@DrawImpacts·
#FromSketchToCover ✨ For the cover of @MolSystBiol Molecular Systems Biology (Vol. 19, Issue 3), we adapted Hope II by Gustav Klimt into a scientific visual language. The goal: preserve the themes of pregnancy, vulnerability, and protection, while translating them into a story about placental immune modulation by Group B Streptococcus. Art history meets molecular systems biology! 🔗 link.springer.com/article/10.152… #SciArt #ScientificIllustration #SciComm #JournalCover #DrawImpacts
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