GroovyMG

478 posts

GroovyMG

GroovyMG

@groovygrahams

Katılım Ekim 2012
728 Takip Edilen111 Takipçiler
rj
rj@sharpie510·
@d_stock07734 @andrewcaravello Thanks for that! I hadn't seen this before. What I did see was a live shot of the ASCO 2022 booth for $NWBO #DCVax and I think Alice was there in-person. She's sitting at a table in the center of the photo wearing one of her trademark floral tops. ❤️
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Andrew Caravello, DO
Andrew Caravello, DO@andrewcaravello·
$MRNA cancer vaccine just terminated in skin cancer. The trial enrolled 46 of a planned 412 patients, ended for “business reasons” with no efficacy data released. Here is why it failed, and why it was always going to fail in this population. The $MRNA approach (developed in partnership with $MRK, whose #Keytruda formed the checkpoint inhibitor arm of the terminated trial) sequences the patient’s tumor, identifies the unique mutations on the cancer cells, and packages those mutations into an #mRNA vaccine. When the patient gets the shot, the mRNA enters their own dendritic cells (the immune system’s teachers), which then translate the mRNA, display the tumor markers on their surface, and instruct T cells to find and kill cells carrying those markers. The mRNA is the lesson plan. The patient’s own dendritic cells are the teachers. The problem is the teachers. Most cancer patients are over sixty, and by that age the body’s teaching cells have largely gone quiet. Decades of inflammation have silenced the master gene (IRF8) that defines a functional teacher cell. A paper from Pittsburgh published this month showed that even in laboratory-prepared dendritic cells, only one in fifty to one in a hundred is actually capable of giving the immune system the right instruction. In the body of a person over sixty, the working fraction is even smaller. $MRNA delivered a perfect lesson plan to a classroom of teachers who can no longer teach. The students (CD4 helper and CD8 cytotoxic T cells) hear the lesson but get the wrong message, becoming tolerant or unresponsive instead of cytotoxic. There is a second problem the $MRNA approach cannot solve. Tumors mutate quickly. The first wave of T cells kills the cancer cells displaying the targeted markers. The cells that survive are the ones that learned to hide those markers. Within weeks, the tumor escapes. This is the escape variant problem that has limited every targeted cancer therapy from CAR-T forward. Two weeks before $MRNA termination, Dr. Pawel Kalinski at the University of Pittsburgh gave a public lecture explaining exactly why this approach would fail and what the solution looks like. His platform manufactures the teacher cells outside the body, in a clean environment where the silencing has not occurred, then sorts for the rare productive subset that actually produces the instructional signal at full strength. The CD4 and CD8 T cells these manufactured teachers educate recognize cancer cells through two mechanisms instead of one: the specific tumor marker AND a stress signal (NKG2D recognizing MIC-A) that cancer cells cannot easily hide from both recognition systems at once. Escape variants get caught by the second recognition system. In his clinical work, this approach produced complete or near-complete responses in seven of nine breast cancer patients in a recent trial. $NWBO owns this platform. Their #DCVax dendritic cell vaccine is built on Kalinski’s technology, manufactured under license from Pittsburgh and Roswell Park. The forward extension Kalinski’s lab is now developing pairs the manufactured teacher with the patient’s own T cells in a closed bioreactor where the teaching signal is delivered correctly, then potentially infuses both the teacher and the educated students back into the patient. The teacher would establish a permanent immune outpost at the injection site. The students would travel through the body and find cancer cells through the dual-recognition system that no current cancer therapy uses. $MRNA model: deliver the lesson plan, hope the teachers can still teach. $NWBO model: build the teacher, deliver the working teacher with the lesson plan already inside, let the working teacher do the instructing. When the teachers in the patient’s body have gone quiet, only one of these models works. Two weeks ago Kalinski explained why. This week $MRNA confirmed it.
Stephanie Seneff@stephanieseneff

A major setback for mRNA cancer vaccine technology. A closely watched phase 2/3 trial of Moderna's product to treat cutaneous squamous cell carcinoma was prematurely terminated, without revealing the reasons for aborting the trial. trialsitenews.com/a/moderna-and-…

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Ron Greco
Ron Greco@gr197667·
$NWBO @Citadel @SECPaulSAtkins @kshaughnessy2 @POTUS @WhiteHouse @ThomasOwenMcCa1 7.3 million up .02 .. really Kenny G?? You say you control the price so when will reality set in for u? Can’t make this fraud up.. Paulie where is the new day?? I mean one of your 6 buddies caved .. already .. so just a matter of time.. someone other than the 7 crooks has the playbook.. right Kenny G?
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apwriter
apwriter@DontheConDrumpf·
It’s getting down to “now or never.” $nwbo
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Noah
Noah@antibearthesis·
Anthony Noto has NEVER sold a single $SOFI share 77% of his entire net worth is already in the stock Now he’s buying again for the first time in 2 years The last time he was buying aggressively… $SOFI rallied 500% You know what happens next right?
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Noah@antibearthesis

🚨 JUST IN: $SOFI CEO ANTHONY NOTO JUST BOUGHT ANOTHER $250,000 OF SOFI STOCK. HE ALREADY BOUGHT $1.5 MILLION WORTH OF SHARES IN MARCH. INSIDERS SELL FOR MANY REASONS. THEY ONLY BUY FOR ONE.

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Jennifer Scott
Jennifer Scott@scott_jenn63528·
$NWBO I have no words for the shorts except F.U
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GroovyMG
GroovyMG@groovygrahams·
@HesterPeirce Companies have seen how the @SECPaulSAtkins has allowed MM to sell naked shares and looked the other way regarding FTD. Rarely, were there fines. When there were fines they were peanuts compares to what the companies made illegally. K Griffin etal
Stephanie 🇬🇧🇺🇸🦍@stephmase22

🙈SEC IS NOT PROTECTING IPO'S🙈🙉🙊 Hester Peirce said that the SEC is not seeing companies going public early in their lives 🤔 Because the SEC doesn't protect these companies they feed them to the predators of Wall Street. BANKRUPTING SMALL COMPANIES IS MORE PROFITABLE THAN GROWING THEM‼️🙊🙉🙈

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Thomas Owen McCaffrey
Thomas Owen McCaffrey@ThomasOwenMcCa1·
May 6th 2026 was my 50th birthday 🎂! (photo credit my son Jake). It was a huge milestone for me, not only did I celebrate my 11th anniversary of being administered the DCVax in March. I never thought I’d make it to 50, especially celebrating with my family. I’m very grateful to so many people who played a vital role in keeping me here. Dr. Linda Liau, Dr. Timothy Cloughesy, Nanette Fong, My family, my friends, F.O.G. However even though I’m a long tail survivor, I’m sure there are many Doctors still dismissing this scientific breakthrough in personalized immunotherapy. To them I say, the proof is in the pudding, I’m not an anomaly. I’m not a one off… I’m thriving, living my life with gratitude, & grace. I KNOW THAT NWBO’s DCVax WILL BE APPROVED. & there is little any Big Pharma executive or MARKET MAKER ON WALL ST. Can do about it. Sorry Kenneth C. Griffin your greed & political donations won’t save you, a wave 🌊 is coming for you… @kshaughnessy2 @LisainNJUSA @HollensbeAmanda @nprpolitics @NorthwestBio @ElvirPons @NHSEnglandLDN @MHRAgovuk @NYMag @TheLastWord @LastWeekTonight @latimes @LAmag
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GroovyMG
GroovyMG@groovygrahams·
@DontheConDrumpf Is it possible to sue the SEC and FINRA for failure to regulate?
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apwriter
apwriter@DontheConDrumpf·
$nwbo Claude: “If Canaccord’s cooperation identifies (broker/dealer clients), the case potentially expands dramatically beyond the seven named market makers.” DOJ and SEC can’t ignore criminal charges with proof that MM delayed treatment for a terminal cancer for years.
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GroovyMG
GroovyMG@groovygrahams·
@shibasachi1230 FDA also has BP influence on Advisory Boards. LP and team made a very informed decision with information available.
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Dan
Dan@shibasachi1230·
$NWBO They are just letting thousands die without a chance! They need to be held accountable for the suffering and death they are allowing! Just so BP can keep their chemo cashflow going!
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GroovyMG
GroovyMG@groovygrahams·
@Investisco Still plenty of time in May for the fabulous News!
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QuebecLibre
QuebecLibre@Investisco·
$NWBO For the record, nobody is allowed to mention approval next month... It will not be tolerated on this board!!! We will not have it!!!
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Cobra
Cobra@cobraalerts·
Have had thousands of DMs so here it is 👇 If you're an options trader - there's a cheat code you should learn that no one is talking about. It makes finding 100% trades way more consistent. I grew an account from $1k → $1,543,756.83 in 1 year using the exact same two concepts every single day. I made a FREE 5-page guide that will teach you this same exact strategy. Like + comment “Guide” and I will send you a DM. (Must be following to DM)
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GroovyMG
GroovyMG@groovygrahams·
@HollensbeAmanda @ThomasOwenMcCa1 Half way is a great milestone for all of you! Congrats of your tenacity, perserverance while maintaining your sense of humor. Thank you for sharing your journey. Glad to be a small part of Braelyn’s cheer squad💜
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Amanda Hollensbe (Braelyn’s Mom)
Amanda Hollensbe (Braelyn’s Mom)@HollensbeAmanda·
Halfway feels big… but we’re still very much in it. Grateful for every person walking alongside us.
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Amanda Hollensbe (Braelyn’s Mom)
Amanda Hollensbe (Braelyn’s Mom)@HollensbeAmanda·
Halfway there. Day 14 of 28 proton treatments. Today has a little bit of everything — a visit to a “cranial prosthesis” boutique (trying to stay one step ahead of the hair loss), treatment as usual, and then heading home for the weekend. There are hard moments — especially as the side effects start to show — but there are still smiles, still laughter. She’s still my Braelyn. Love her so much. One day at a time. 🤍 #BrainTumor #Glioblastoma #PediatricCancer #CancerSucks #DCvaxForBraelyn
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GroovyMG
GroovyMG@groovygrahams·
@iluminatibot It’s not just Pelosi! The House is the millionaires club and the Senate the multi-millionaires club. Majority are insider trading so they don’t want it monitores or changed. DC proyecta their own. We just get to pay the bill!
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illuminatibot
illuminatibot@iluminatibot·
Why did Martha Stewart go to prison for insider trading and Nancy Pelosi has not?
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Jane of the North
Jane of the North@JaneotN·
Look at his face. Imagine being six years old, and this monster is raping and sodomizing you. He's been sentenced to 60 days in jail. He doesn't have to register as a sex offender. When you vote Republican you give power to men who violently terrorize children.
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GroovyMG
GroovyMG@groovygrahams·
@kshaughnessy2 @PK_Fund But if they don’t start covering at .20 it will be 10x worse at $2.00. So, to PK point why aren’t they starting to buy before big approval. Thank you Kristen for all the knowledge you share.
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kristen shaughnessy
kristen shaughnessy@kshaughnessy2·
@PK_Fund They can’t. Every cent the stock goes up costs them a ton of money. And the fear or margin calls. A legitimate short would want the price higher. A naked short (counterfeit share) cannot have the price go up.
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PK_Fund
PK_Fund@PK_Fund·
$NWBO stupid question. The shorts have the same info as we have. Anticipating approval, would'nt you think they would have started covering awhile ago?
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