Joe Grzymski

@JohnDSailer Fewer than 5% of faculty...not news

This is fascinating. More than 100 Yale professors have called for an audit of the university's sprawling bureaucracy. The audit, they say, would "preempt potential federal intervention" and send the message: "Yale prioritizes intellectual vitality over bureaucratic inertia."

@SashaGusevPosts Great post/summary. Thank you

I wrote about the ongoing debates over genomic data sharing and the use of such data for "abhorrent science", including some perspective papers that came out last month. A few key points: 🧵

@SashaGusevPosts @tonygill3 I think 5k is actually quite important because it is roughly the time of the expansion of states, uses of grain, and sedentism. All ideas from James Scott's fascinating book Against the Grain.

@tonygill3 Different methods are powered for different timescales, I broke it up at "recent" history where one class of methods generally stop. Next post is about 10k, 50k, and beyond.

I wrote about the paucity of genetic evidence for very recent selective sweeps and the generally odd and sporadic nature of the ones we do see. A 🧵:

#OnTheBlog: We summarize the five fast facts of what we uncovered in our recent analysis with Renown Health and the Healthy Nevada Project® that emphasizes the importance of genetic approaches to breast cancer screenings. @alexbolze @grzymski Read more: bit.ly/3W2fiYC

@meghanclare Their values are of biblical proportions...

Using a strategy combining both monogenic and polygenic approaches, researchers achieved a better identification of high-risk #BreastCancer patients in a large retrospective study bit.ly/49fTyM2 @alexbolze @grzymski #GIMO #PopulationScreening #BRCA1 #BRCA2 #PALB2 #ATM

@JayTCullen Brace yourself for some controversy

@alexbolze @ETCirulli @kellyschiabor @my_helix @AurelieCobat @LaurentAbel4 @casanova_lab @SanchoShimizu @ChrisChiuLab @jacquesfellay Awesome thread @alexbolze ! Thank you!

Special thanks to Astrid Marchal for doing most of the work. To @ETCirulli @kellyschiabor @my_helix @grzymski & Iva To @AurelieCobat, @LaurentAbel4, @casanova_lab To @SanchoShimizu @ChrisChiuLab To @jacquesfellay (for teaching us everything on HLA and infectious diseases)

Why this difference between our studies? I am not sure. It might be linked to population stratification. HLA-B*15:01 is a common allele, and its frequencies varies a lot between populations in the US, but also within Europe. => important to really use genetic PCs in the test

Thank you so much to my @renownhealth colleagues at South Meadows and to the @RenoOrtho for exceptional care yesterday when I had to make a patient visit for knee surgery! Still got to speak about healthynv.org. Grateful for the top notch care in Reno/Tahoe.

Will seriously damage the post-transcriptional modification and translation job markets in Idaho

@mbeisen Works of Law, Tortell, Price, Lam- come to mind but I'm out of the loop for a long while. The awesome chemist @JayTCullen would know more recent literature

are there lab experiments looking at ocean iron fertilization or are they all field studies?

@dsheehan002 @MHendr1cks I mean why not follow the actual science and eat the metformin dosed worms…that’s the path to a new WR

@HealthyNV @mccashie and others! great perspective re: CAD, monogenic and polygenic risk.

Cancer risk assessment is not consistently offered and can lead to inequity in care. Helix has shown #populationgenomics can be used to reduce this. In this #ASHG2022 poster, @alexbolze takes this analysis further. Check out our presented research here: bit.ly/3DamHu6

@MHendr1cks I may have gotten a 30% in org but all blame goes to my study partner

@Amelia_Lindsey It is completely worth it and you can experience the awesomeness with a snorkel and never going below the surface (you’ll be in a dry suit)

Tomorrow, after years of advocacy by Americans working to improve our mental health system, 988 will become our new nationwide number for suicide prevention, mental health and substance use crises. Call or text 988 for a trained counselor who can provide support. #988Lifeline

The incomparable @alexbolze with an awesome digest of our recent work led by the brilliant pair of @kellyschiabor and @ETCirulli - thanks to @HealthyNV participants and to @renownhealth for all the support!

If a weapon is so dangerous that a squad of police officers are too afraid to confront a single person wielding it, that weapon should be banned.

Senators bankrolled by the NRA: Mitt Romney: $13,648,000 Richard Burr: $6,987,000 Roy Blunt: $4,556,000 Thom Tillis: $4,421,000 Marco Rubio: $3,303,000 Joni Ernst: $3,125,000 Josh Hawley: $1,392,000 Mitch McConnell: $1,267,000 Ted Cruz: $176,000 An absolute disgrace.