Hayder Hussein

What does the FOX(O) say? High iron: hepcidin! ow.ly/jf9o50Tr7UT #redcellsironanderythropoiesis

And it's GOOOOOOOLD for Megan Richter! Oooh yes!! What a morning for the Brits on the bridge. #ParalympicsGB 🥇#ParaTriathlon

Are you a clinician who sees patients with secondary polycythaemia? Are you frustrated by the lack of an evidence base for treating these patients? Does your practise differ from your colleagues when treating these patients?

@MorphologyAmigo @Dr_MSU @nihardesai7 @TalhaBadarMD @PriyaSriRajah @blood_academy @WilsonAndrewDr @BijoyTelivala Ivosidinib is an IDH1 inhibitor, so not applicable here. Enasidinib (IDH2 inhibitor) not a UK option at the moment…a case of treat with what you have…

@Dr_MSU @nihardesai7 @TalhaBadarMD @PriyaSriRajah @blood_academy @WilsonAndrewDr @BijoyTelivala @h4yder I think what @nihardesai7 and I are trying to say is you can do anything you like The idea of these regimes is quality of life and disease control Fancy Heroics which will break the patient in half with side effects probably wont do him any favours Monosomy 7 is bad luck

Clinical Q From this Week 76M MDS/AML Flow Blasts: 18% Morphology BM Blast Count 35% Some Comorbidities Not Fit for Intensive Rx Genetics Below 👇👇 What would you Do 😃 #hematology #hemepath #medicine #medtwitter Also We Support our Striking Colleagues #BMA😃

@MorphologyAmigo @nihardesai7 NICE TA currently suspended….awaiting regulatory plans from the company…

@nihardesai7 Is this NICE approved @h4yder I have an RS for whom I couldn’t get Luspatercept :(

Imetelstat approved for low-intermediate risk MDS with transfusion dependent anemia 👍🏼 fda.gov/drugs/resource… #MedTwitter

@richardbuka @BritSocHaem Drug cost?

Packed Crucible Session #BSH2024. My favourite session of BSH (and any session of any conference ever). This year: What is the greatest threat to the future of haematology. Is it AI!?

Strategies to reduce relapse risk in patients undergoing allogeneic stem cell transplantation for #AML #leusm |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…

Chromatin patterns 🧵 [1] How many times have you heard phrases like: "Fine chromatin" "Dotted like with a pencil" "Smooth chromatin" "Clumped chromatin" "like a football (some of y'all may call it a soccer ball)"...? What do they mean and how do you make sense of it all? How does the chromatin relate to the morphology? Let's take a deep dive. 👇 #OnlyCells #Chromatin #BackToBasics

@MorphologyAmigo @veraghali @NicoGagelmann Heard and read about plateletpharesis but have never had to do it, cytoreduction being the mainstay. Having said that I do know of a case where patient had a count of >3000 and resistant to max dose hydrea, pegasys and ruxolotinib…

@veraghali @NicoGagelmann With respect The only Apheresis indication for ET is If a pregnant woman has Very high platelets and is pregnant and somehow the newborn is under threat. Read this in a textbook once Cytored 👍👍 No one would connect a high Plts patient for an exchange to my knowledge @h4yder

Patient with burning pain in the hands and thrombocytosis. Diagnosis?

Excellent presentation by Vaishali o risk factors and outcomes of CAR T manufacturing failure. #ASH2023

@kungfudoctor I knew you’d be a fan of Q

Using a GIF, who is your favorite Star Trek character!

Very pleased to able to share our latest research on platelet activation in #VITT authored by @richardbuka and @sam_310 from @bhamplateletgrp and @ICVS_UoB published in @BloodJournal yesterday. We show that PF4 itself activates platelets via the TPO receptor c-MPL.

@ManniMD1 I thought that Sjogren’s is associated with MALT lymphoma which often has an IgM paraprotein. Although by definition this isn’t MGUS…

ashpublications.org/blood/article/… In case the link above didn’t work.

I don’t think MGUS is actually associated with Sjogrens. Or many other auto-immune diseases for that matter. sciencedirect.com/science/articl… So, I will respectfully disagree with you there.

Super pleased to see that NICE has approved Ruxolitinib for PV in England !! @MPNVoice FDG published today. Let’s get on and test this drug in the front line as the Mithridate study being run jointly between 🇫🇷 and 🇬🇧 with @jjkiladjian

@BookshopOTGreen Ah so sorry to hear this, my boys and I loved having the bookshop nearby. Good luck with the next chapter, and hope that it continues to bring happiness to the local area!

After two and a half years in Bournville, The Bookshop on the Green will be closing. Our last trading day will be Thursday 24th August. But this is not the end! We will continue to host our events until we can find a suitable premises to relocate to.

@Existential_Doc Any tips for severe haematuria outside of bladder washouts? Difficult as TxA contraindicated…

Link for tranexamic acid via CSCI austinpublishinggroup.com/hematology/ful… Link for omeprazole via CSCI jpsmjournal.com/article/S0885-… Scottish palliative care guidelines for bleeding in palliative care palliativecareguidelines.scot.nhs.uk/guidelines/pal…

Managing bleeding in palliative care A Thread 🧵 One of the most difficult topics to discuss. Bleeding reminds us all of our own fragility and elicits an immediate response from all who witness this. Lets’s start with bleeding from local areas

@richardbuka Maybe best place to intervene is at pharmacy/dispensary level. It’s quite a good way of improving prescribing patterns…@nickduncan31?

@h4yder Already done

This paper came out 9 years ago showing less is more when it comes to oral iron - once a day or alternate days is optimal. Yet, still patient after patient is on BD or TDS 🤢. WHAT DO WE HAVE TO DO TO STOP CLINICIANS DOING THIS? Just causes GI probs. ashpublications.org/blood/article/…

Our first regional AML day. Excellent talks and stimulating discussions.@UhbTeam @FWANDROO @HaemOnc @francescakinse3 @h4yder

@MorphologyAmigo Have never come across this scenario! Broadly speaking allergies need close scrutiny-thorough history, speak to pharmacy and immunology. ATRA is so crucial though that I’d be likely to press on with it (maybe the dexamethasone cover for differentiation syndrome will ameliorate!)

I think Severe Soya Allergy and ATRA dont go well in the same cocktail never been confronted by it myself but have read about it in books Perhaps some myeloid friends might be able to cite their experience if ever faced with a situation like this ? @h4yder