Haley Randolph

very excited to share the last chunk of my PhD work, now available on @biorxivpreprint! in this work, we explore how cis-regulatory variation and gene-environment (GxE) interactions influence immune response diversity directly in a cohort of hospitalized COVID-19 patients 1/n

Why do some COVID-19 patients fare worse than others? @SachMorin’s team used AI to study 300 hospitalized patients and understand how specific markers related to their immune response and the infection affected the clinical outcome. Read his blog post: mila.quebec/en/article/exp… @he_randolph

Pourquoi certains patients atteints de la COVID-19 s’en sortent-ils moins bien que d’autres? L’équipe de @SachMorin a utilisé l’IA pour étudier 300 patient·e·s hospitalisé·e·s et comprendre comment certains marqueurs spécifiques liés à leur réponse immunitaire et à l’infection influençaient l’évolution clinique. Lire l'article de blogue : mila.quebec/fr/article/ana… @he_randolph

We are excited to host Professor Luis Barreiro (@LB_Barreiro) from @UChicago for two talks this week! Come learn about the evolution of the human immune system!

for Sasha & his family gofundme.com/f/remembering-…

absolutely devastating — i feel incredibly grateful to have had you as a coach and you will be missed dearly, Sasha 🤍

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen

8th NYC Inborn Errors of Immunity symposium just concluded. 29 outstanding talks! Genetics, AI, Fundamental and Clinical Immunology, Bioinformatics, Animal models. Fantastic attendance. Thank you @joshuamilner2 for co-hosting. @KidsAtColumbia

need Luann at a Traitors roundtable

#WeekendRead! #MysterySolved! Why the same mutation can be pathogenic or not? @bogunovicLab @stewart_otay &co show @Nature that epigenetic controls the random expression of 1 allele in 5% of all genes, explaining incomplete penetrance of monogenic diseases nature.com/articles/s4158…

Human embryo editing against disease is unsafe and unproven despite rosy predictions @Nature @ShaiCarmi @HankGreelyLSJU @WiringTheBrain nature.com/articles/d4158… Heritable polygenic editing: the next frontier in genomic medicine? @juliansavulescu nature.com/articles/s4158…

Thrilled to share our publication @NatImmunol led by the incredible @Nargis__Khan_14 @kimaimytran and amazing collaborators @soehnleinlab @LB_Barreiro @bgyipp @KhaderShabaana fascinating how a fragment of fungi can mitigate lung pathology to influenza rdcu.be/d5AEw

Excited to kick off 2025 with our latest publication! We've developed TGFM, a new statistical method for identifying the causal tissue and gene underlying GWAS disease loci—providing new insights into the biology behind GWAS signals. nature.com/articles/s4158…

@stewart_ojay @BogunovicLab @Nature @KidsAtColumbia @SinaiImmunol @SinaiMSTP @IcahnMountSinai @ConorGruber @roosheelpatel 🥳🎉💃🏼 congrats O’Jay!!! 🍾🍾🍾

@BogunovicLab @Nature @KidsAtColumbia @SinaiImmunol @SinaiMSTP @IcahnMountSinai Huge thanks to my mentor Dusan @BogunovicLab , wonderful lab mates @ConorGruber @he_randolph @roosheelpatel, Meredith, Marta, Sofija, Christos, all our collaborators and of course the patients.

Excited to share my PhD work with @BogunovicLab in @Nature! We highlight the importance of monoallelic expression on the penetrance of genetic disease. nature.com/articles/s4158… @KidsAtColumbia @SinaiImmunol @SinaiMSTP @IcahnMountSinai #InThoseGenes

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼 @KidsAtColumbia @SinaiImmunol

Excited to share our pre-print "The multi-scale complexity of human genetic variation beyond continental groups" biorxiv.org/cgi/content/sh… Global Genomic Network Communities browser: sohail-lab.shinyapps.io/GG-NC/ Github: github.com/mariajpalma/GG… See🧵thread by lead author @MaxolotlMad

i don't capitalize anything bc im against capitalism

Excited to share the final chapter my PhD research on @medrxivpreprint! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. medrxiv.org/content/10.110…

Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in @Nature thanks to the work of many! nature.com/articles/s4158…

@gushamilton @biorxivpreprint thank you!

@he_randolph @biorxivpreprint This is really nice work Haley. I really look forward to reading it.

very excited to share the last chunk of my PhD work, now available on @biorxivpreprint! in this work, we explore how cis-regulatory variation and gene-environment (GxE) interactions influence immune response diversity directly in a cohort of hospitalized COVID-19 patients 1/n