Dr. Heather Hook

@serio_renata @anafiszbein Congrats!

Beyond excited to share I’ve been awarded the NSF GRFP! So thankful to everyone who helped me pull this together.

@fuxmanlab @TrevorSiggers @scarrascopro @heatherJHook @BU_biology develop a transcription factor-aware test to predict #noncoding cancer drivers and analyse the impact on transcription factor binding - especially ETS factors #CancerResearch @natrescancer doi.org/10.1038/s41467…

Excited to share our recent paper in collaboration with @TrevorSiggers and @r_tewhey , led by @scarrascopro and @HeatherJHook . We found hundreds of potential cancer drivers in promoter regions which displayed altered cofactor recruitment. 1/7 nature.com/articles/s4146…

Proximity sequencing (Prox-seq) from @SavasTay_UChi and colleagues combines the proximity ligation assay with single-cell sequencing to simultaneously quantify proteins, protein complexes and mRNAs in high throughput. nature.com/articles/s4159…

Online Now: Subclonal mutations in epigenetic regulators bring fitness in times of stress dlvr.it/SdhWZ3

Still can’t believe this happened!

I've been writing research articles for over 10 years now and one of the hardest parts is writing consistently and efficiently without procrastinating. I'm going to share some of my tips here 🧵 1/10

Congratulations to Dave Bray, Heather Hook and other lab members for their new paper out in Cell Genomics today describing the CASCADE method for profiling regulatory complexes affected by non-coding variants !! (#SNP, #GWAS, #QTL) Great work all! cell.com/cell-genomics/…

Furthermore, we show how CASCADE can be used to screen differential recruitment of COFs to ~1700 non-coding variants in human macrophages and identity perturbed ETS domain binding at these loci. (3/3) #epigenetics #genomics #cellbiology #molecularbiology

In this work we describe the development of a new method, CASCADE. It’s an array-based HT method to profile cofactor recruitment to DNA. We demonstrate how the method is sensitive enough to characterize condition specific recruitment of COFs to cis-regulatory elements. (2/3)

After a lot of work, I am happy to announce that my latest manuscript has been published in @CellGenomics 🎉! You can check it out here ➡️ cell.com/cell-genomics/… (1/3)

Hello, World! Welcome to our inaugural issue! 🎉

Excited to share my first ever scientific paper with Tim Hughes now out in @GenomeBiology examining whether various models of TF binding (with or without spacing/orientation constraints) are consistent with the global properties of regulatory sequences 1/ genomebiology.biomedcentral.com/articles/10.11…

Oncolytic virotherapy: Potentially a game-changing tumor treatment dlvr.it/S29dXP

In our June issue: Systemic immunity in cancer, by K Hiam-Galvez @InflammatoryDC, B Allen @ballen1725 & M Spitzer @SpitzerLab. go.nature.com/3sa8qWH @UCSFCancer, @UCSF

Spear-ATAC, a method for assaying open chromatin and Crispr guides, is out! Congrats to @Sarah_E_Pierce and @JeffreyGranja nature.com/articles/s4146…

@AlannaCarey3 Woohooo congrats!

After three really great rotations, I’m very excited to be joining the lab of Dr. Jerry Chen for my thesis work!

New Resource out now! A comprehensive annotation of intra-tumor #heterogeneity provides detailed insight into #tumor evolutionary #dynamics bit.ly/3x8TBrc @VanLooLab @TheCrick

In the latest issue! #Genetically engineered myeloid #cells can reverse the #immunosuppressive environment developed during #metastatic progression bit.ly/3gac7JH @rosiekaplanmd @NCIResearchCtr @NIH

This manuscript from my lab gives me joy: Global discovery of lupus genetic risk variant allelic enhancer activity. @XiaomingL2 @RayJohnP4 @CarldeBoerPhD @EmilyMiraldi @SreejaParamesw2 @tareian_it_up @NatureComms #lupus doi.org/10.1038/s41467…