HILAL BASHIR

Online Now: Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth dlvr.it/TTDshj

Excited to share that our work has been published in @Cancer_Cell @melodyzeng @WeillCornell In this study, we uncover how chronic psychological stress promotes tumor progression through a microbiota–phage–fibroblast signaling axis. We show that stress-induced activation of bacterial prophages drives TLR9 signaling in cancer-associated fibroblasts, leading to local glucocorticoid production that suppresses anti-tumor B cell immunity. These findings reveal an unexpected mechanism linking the gut microbiota, bacteriophages, the tumor microenvironment, and adaptive immunity, while highlighting new therapeutic opportunities for cancer immunotherapy. This project has been an amazing journey, and I'm sincerely grateful to my PI, Dr. Melody Zeng, my co-authors, collaborators, and everyone in the Zeng Lab for their invaluable support, and collaboration throughout this work. I'm thankful to the @CancerResearch for supporting my postdoctoral training as a CRI Irvington Fellow. sciencedirect.com/science/articl…

Online Now: Intratumoral B cells under stress dlvr.it/TTCrHz

Thrilled to share the 1st cancer paper out of our lab @Cancer_Cell !😀@hilalbashir65 @WeillCornell We show chronic stress drives translocation of gut bacteria w lytic phages to tumors&unleashes an phage-fibroblast-B cell circuit to promote tumor growth sciencedirect.com/science/articl…

@BSNLCorporate @CMDBSNL @robertravi21 Before these friendly plans, bsnl needs to work on basic customer care support which is currently complete disaster. Being the customer from past decade, I am emailing bsnl from past many months regarding an urgent issue they don't even bother to reply.

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@lexfridman @JMilei Seen first leader to have such an extensive knowledge

Here's my conversation with Javier Milei (@JMilei), President of Argentina 🇦🇷. I'm posting it in both English (overdubbed) & Spanish (with subtitles) here on X and everywhere else. See comment thread for Spanish version and links. The Spanish version has me speaking Spanish 🔥 Timestamps: 0:00 - Introduction 3:27 - Economic freedom 8:52 - Anarcho-capitalism 18:45 - Presidency and reforms 38:05 - Poverty 44:37 - Corruption 53:14 - Freedom 1:07:26 - Elon Musk 1:12:54 - DOGE 1:14:56 - Donald Trump 1:20:56 - US and Argentina relations 1:28:05 - Messi vs Maradona 1:36:58 - God 1:39:05 - Elvis and Rolling Stones 1:42:45 - Free market 1:49:46 - Loyalty 1:52:23 - Advice for young people 1:53:49 - Hope for Argentina

@jkagan1 @globalimmuno Thanks

@hilalbashir65 @globalimmuno Yes. We have examined the questions you asked in elderly mice (over 90 weeks) and elderly humans (over 70 years). There will likely be exceptions, but all signs suggest that hDCs can be elicited in mice and humans of diverse ages.

Please ask questions for today's Global Immunotalk by Jon Kagan HERE by replying to this tweet. Don't forget to mention #globalimmuno. Jon will use the account @jkagan1 to answer questions.

@RobertKennedyJr Problem is healthy options are there but people are still stuck with unhealthy stuff

Ultra-processed food is driving the obesity epidemic. When we get President Trump back in the White House and me to Washington, we're going to fix our broken food system and Make America Healthy Again. #MAHA 🇺🇸

@OdedRechavi To study aquatic bird behaviour.

How do i justify buying this in the grant's budget?

@FoxNews Well the list looks like to be for the whole building.

'OH MY GOD': Trader Joe's, known for its affordable prices, facing heat after man reveals the whopping amount it cost him to get groceries to feed his six children. Americans react to the "insane" viral video as inflation rocks shoppers. trib.al/o9LFOzC

@IndianTechGuide Life style with lack of physical exercise, unhealthy food and lot of screen timing especially with social media are just disaster for your body

Students collapsing due to heart attacks is concerning.

The lack of scientific terms and vocabulary in many of the world’s sign languages can make science education and careers inaccessible for deaf people and those with hearing loss. Meet the people working to add scientific terms to sign languages go.nature.com/3uTIZQt

Take a GOOD look at this study. It is not only brilliant and practice changing, but also life changing. Older people develop dementia. "Dementia is the general name for a decline in cognitive abilities that impacts a person's ability to perform everyday activities. This typically involves problems with memory, thinking, and behavior, a disruption in thought patterns, emotional problems, difficulties with language, and decreased motivation." Hepatic encephalopathy is a brain dysfunction specifically seen in cirrhosis patients. Hepatic encephalopathy occurs when the damaged liver no longer cleans up toxins like it should. Toxins like ammonia then build up in the bloodstream and can affect brain function resulting in confusion, disorientation, and erratic behavior - and a LOT of symptoms and signs of hepatic encephalopathy overlap with dementia. Unlike classical forms of dementia such as Alzheimers Disease, hepatic encephalopathy related brain dysfunction which can mimic dementia forms, is treatable and reversible - which means, we can bring people who were considered never to return, back to us. In this intense study published in JAMA Open Network, clinical researchers at the Veterans Affairs medical centers across USA, studied medical records of more than 175,000 U.S. Veterans over a 10-year period. All of them had dementia. None of them were diagnosed from a cirrhosis point of view. And they were continued on best supportive care and comfort care for dementia. But the clinical researchers found something. Close to 10% of these patients had undiagnosed cirrhosis and possible hepatic encephalopathy. Let that sink in: 10% of 175,000 patients with dementia for which they were doomed to end of life care, had in fact a treatable and reversible cause for the brain dysfunction. The lesson here is simple. If you encounter an older patient and they show symptoms and signs of dementia, do not stop at dementia. But screen them also for liver disease and hepatic encephalopathy. This could be life changing for them, because we can bring them back from the dark, back into the light where we can see them better and they can see us too. There is hope. Original paper: Undiagnosed Cirrhosis and Hepatic Encephalopathy in a National Cohort of Veterans With Dementia by the Hepatology Master @JasmohanBajaj and his team jamanetwork.com/journals/jaman… Lay discssion via @statnews Some dementia patients might have reversible symptoms caused by cirrhosis, study says statnews.com/2024/01/31/dem…

@Nick_Collins11 Congratulations!!

Happy to have this out. We show that dietary restriction enhances memory responses by promoting memory T cell-gut microbiota-myeloid cell cooperation. Congrats to @SeongJiHan , thanks to our collaborators and Yasmine @BelkaidLab for huge support. pnas.org/doi/epdf/10.10…

Mohammed Hijab admits Prophet Muhammad was a war criminal because he also allowed the killing of women and children. This guy keeps destroying Islam.

@IndiaDST @DrJitendraSingh @rajesh_gokhale @guptaakhilesh63 @serbonline Deepest condolences

.@IndiaDST family expresses it's deepest condolences on the demise of Professor MS Swaminathan, the legendary agricultural scientist & a key architect of the country’s ‘Green Revolution’. @DrJitendraSingh @rajesh_gokhale @guptaakhilesh63 @serbonline

@IiserMohali Congratulations

Congratulations Dr. Mahak Sharma, Department of Biological Sciences. Dr. Sharma has contributed significantly to our understanding of the mechanisms by which cellular cargo is delivered to lysosomes for degradation.

@director_imtech @CSIR_IND @CSIR_HRDC @HRDG_CSIR Congratulations

Congratulations Dr Ashwani Kumar on the award of the Shanti Swarup Bhatnagar Prize for the year 2022 in Biological Sciences. It is indeed a proud moment for the IMTech Family. Wish you many more such accomplishments. @CSIR_IND @CSIR_HRDC @HRDG_CSIR

@VidyaKrishnan This Deepak Kid was in his diapers when Romila used to write about Our nation.

Two men with the combined intelligence of a rabbit are talking about how Romila Thapar should leave India! Woh aurat nabhe saal ki hai. Like.. she's 15 years older than India.. aur yeh decide karenge ki woh kitni bhatriya hain! Disguting.