indrani

In this paper, we tracked endogenous proteolytic signatures following physical interventions , showing quantitatively how proteolytic peptide patterns are reshaped in food mixtures. Peptidomics mapping of proteolysis highlights triple activation of spr… sciencedirect.com/science/articl…

How does the gut contribute to genesis of #Parkinsons disease? Gut macrophages gobble up misfolded alpha-synuclein, a toxic protein-> signal T cells-> travel to the brain New @Nature, in experimental model nature.com/articles/s4158…

A message from a Kindergarten teacher: After forty years in the classroom, my career ended with one small sentence from a six-year-old: “My dad says people like you don’t matter anymore.” No sneer. No malice. Just quiet honesty — the kind that cuts deeper because it’s innocent. He blinked, then added, “You don’t even have a TikTok.” My name is Mrs. Clara Holt, and for four decades, I taught kindergarten in a small Denver suburb. Today, I stacked the last box on my desk and locked the door behind me. When I started teaching in the early 1980s, it felt like a promise — a shared belief that what we did mattered. We weren’t rich, but we were valued. Parents brought warm cookies to parent nights. Kids gave you handmade cards with hearts that didn’t quite line up. Watching a child sound out their first sentence felt like magic. But that world slowly slipped away. The job I once knew has been replaced by exhaustion, red tape, and a kind of loneliness I can’t quite describe. My evenings used to be filled with construction paper, glitter, and glue sticks. Now they’re spent filling out digital reports to protect myself from angry emails or lawsuits. I’ve been yelled at by parents in front of twenty-five children — one filming me with his phone while I tried to calm another child mid-meltdown. And the kids… they’ve changed too. Not by choice. They arrive tired, anxious, overstimulated. Their tiny fingers know how to swipe a screen before they can hold a crayon. Some can’t make eye contact or wait in line. We’re expected to fix all of it — to patch the gaps, heal the trauma, teach the curriculum, and document every move — in six hours a day, with resources that barely fill a drawer. The little reading corner I once built, full of soft beanbags and paper stars, was replaced by data charts and “learning metrics.” A young principal once told me, “Clara, maybe you’re too nurturing. The district wants measurable results.” As if kindness were a weakness. Still, I stayed. Because of the small, holy moments that no spreadsheet could measure — a whisper of, “You remind me of my grandma.” a shaky note that read, “I feel safe here.” a quiet boy finally meeting my eyes and saying, “I read the whole page.” Those tiny sparks were my reason to keep showing up. But this last year broke something in me. The aggression grew sharper. The laughter in the staff room turned to silence. The light went out of so many eyes. I watched brilliant teachers — my friends — vanish under the weight of burnout, their joy replaced by survival. I felt myself fading too, like chalk on a board that’s been wiped one too many times. So today, I began my goodbye. I pulled faded art off the walls and tucked thirty years of handmade cards into a single box. In the back of a drawer, I found a letter from a student from 1998: “Thank you for loving me when I was hard to love.” I sat on the floor and cried. No party. No applause. Just a handshake from a young principal who called me “Ma’am” while checking his notifications. I left my rocking chair behind, and my sticker box too. What I carried with me were the memories — the faces of hundreds of children who once trusted me enough to reach out their hands and learn. That can’t be uploaded. It can’t be measured. It can’t be replaced. I miss when teachers were partners, not targets. When parents and educators worked side by side, not in opposition. When schools cared more about wonder than numbers. So if you know a teacher — any teacher — thank them. Not with a mug or a gift card, but with your words. With your respect. With your understanding that behind every test score is a heart that cared enough to try. Because in a world that often overlooks them, teachers are the ones who never forget our children.

Indrani Bera’s research fabric reveals how proteins in sprouted chickpeas break down over time under different growth conditions. She imagines turning this intricate pattern into a coaster or wall art. #CutFromTheSameCloth #FoodScience #ResearchInFabric

Can't keep up with all the new computational tools? Here are the top ones to know for biology, chemistry and informatics Bioinformatics BLAST MAFFT Foldseek MMseqs Biotite Biopython Biopandas RCSB PDB UniProt InterPro 𝘊𝘩𝘦𝘮𝘪𝘯𝘧𝘰𝘳𝘮𝘢𝘵𝘪𝘤𝘴 & 𝘴𝘮𝘢𝘭𝘭 𝘮𝘰𝘭𝘦𝘤𝘶𝘭𝘦𝘴 Chembl Rdkit Boltz-2 Pharmit (pharmacophore search) AutoDock/GNINA REINVENT BindingDB datamol & molfeat GPCRdb 𝘈𝘯𝘵𝘪𝘣𝘰𝘥𝘺 𝘪𝘯𝘧𝘰𝘳𝘮𝘢𝘵𝘪𝘤𝘴 ANARCI AbYsis TAP SabDab PlabDab AbodyBuilder/ImmuneBuilder IgBlast @tamarindbio Database & immune protein annotator BioPhi 𝘗𝘳𝘰𝘵𝘦𝘪𝘯 & 𝘮𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘥𝘦𝘴𝘪𝘨𝘯 AlphaFold2 Boltz-2 RFDiffusion ProteinMPNN PyRosetta BindCraft RFpeptides Chai-1 𝘉𝘪𝘰𝘱𝘩𝘺𝘴𝘪𝘤𝘴 & 𝘥𝘺𝘯𝘢𝘮𝘪𝘤𝘴 GROMACS OpenMM OpenFE (+RBFE) OpenFF NAMD AmberTools PLUMED Try out @tamarindbio to use (nearly) all of them, in a secure, scalable environment with no setup. required. On Tamarind, using our web interface or AI Copilot, you can connect all of the aforementioned tools together, deploy your custom tools, and create specialized versions for your own data.

RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom de novo design of macrocyclic peptide binders nature.com/articles/s4158…

Proteins operate on a short timescale — on the order of a millisecond, or even faster go.nature.com/4kI89Gt

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… @NEJM nytimes.com/2025/05/15/hea…

#Dublin #spring #FlowerPhotography #Flowers

#spring #FlowerPhotography #tulips

Happy International Women’s Day! We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Tell us about the women who inspire you the most - and why #InternationalWomensDay

New insights link metabolic dysfunction to #Parkinson'sDisease. Impaired alpha-KGDH disrupts mitochondrial metabolism, increasing #LipidPeroxidation. Targeting this enzyme may offer therapeutic potential. @northwesternu @NatureComms doi.org/g863kh medicalxpress.com/news/2025-03-m…

Top 5 advances in medicine this week (🧵) 1. Vitamin C modifies the amino acid, lysine, to form VitCyl-lysine This is a novel post-translational modification: it promotes immunity and (in mice!) boosts anti-PD1 immunotherapy to kill cancer Whether vitamin C can also boost immunotherapy in humans isn't yet clear, but trials are ongoing Study: cell.com/cell/abstract/…

NEW: An Oxford study estimating the environmental impact of 57,000 food products in the UK and Ireland has been published. Researchers found that plant-based foods have the lowest environmental impacts and more nutritious foods are often more sustainable. 🧵⬇️

news-medical.net/news/20250128/… Process of protein breakdown and peptide release in legume proteins..

Most people misunderstand the Central Dogma. In school, perhaps you were taught it as “DNA → RNA → protein.” But that’s a massive oversimplification. Francis Crick’s real "Central Dogma" was about what *cannot* happen in a cell. Let’s break it down. 🧵

Researchers used AlphaFold alone (no wet-lab experiments; no cryo-EM etc.) to build a structural model and predict how a huge complex in cells, made of 17 proteins, spans across the bacterial cell envelope to transduce force for motility. Can anyone tell me if this is a first?

Women In Research Ireland are excited to host a research showcase in celebration of International Women's Day! The event will take place in Dublin and will include short presentations from women about their topic of research. Short abstracts may be submitted via forms.gle/5r1gs5MoQtKwCU… before the 7th of February 2025. We look forward to seeing you there!