Michael Moran | APC Injury

Lingering pathogens have been a big part of Chinese medicine, documented as early as 2,000 B.C. So much of the medicine operates around the interstices, ecapsulated spaces, and empirical evidence that lingering pathogens are not considered special or even rare.

@higswriter One of Berberine's effect is that it causes apoptosis of dendritic cells. It's effect is tolerogenic which can be undesirable in certain situations, desirable in others.

@internetuserf12 Are you saying berberine hurts the immune system?

In Chinese medicine, prolonged use of bitter-cold antivirals is thought to drive lingering pathogens deeper rather than eradicate them. Mechanistically, many can directly inhibit microbes while also suppressing the immune machinery needed to clear them. Shikonin and Berberine, for example, can inhibit dendritic-cell metabolism, maturation, and costimulation - reducing inflammation, but potentially promoting immune tolerance and impaired antigen presentation. This convergence between traditional “pathogen entrenchment” and modern APC biology is the subject of my book. Antimicrobials work great for acute pathogens when the host's immune mechanisms are still in tact, but Lingering Pathogens come with a world of complications that must be met with nuance and precision.

@WoteverYaLike Is "normality" getting covid on a regular basis?

@internetuserf12 I was more vulnerable than the average perso, but saw the need for normality mentally so we went for it. As much as I didn't want Covid, balance was needed and I am so pleased I went back to normality. We had the vaccines - and a less severe virus. I've been fine.

Illness ghosting happens when someone’s illness outlasts other people’s willingness to care: friends and relatives abruptly disappear from their life. In oncology, it’s called "cancer ghosting" because it's so dramatic and painful; at its most extreme, it produces a kind of social death. That is precisely what the “return to normal” felt like to everyone still vulnerable to SARS‑CoV‑2: society’s concern and responsibility to each other expired before our illness and vulnerability did. In summary, it did not and does not feel good if you can imagine.

@TripWorryf503 @frikitona_spin Same

@frikitona_spin @internetuserf12 I can only tolerate, literally, a pinch if creatine and still fet a good effect from it. 🤞

In the coming weeks, I’m replacing APC Restore capsules with a much more affordable organic freeze-dried raspberry electrolyte drink - more tolerable for more people and far less time-consuming to make. Creating a sustainable alternative to the no-holds-barred oxaloacetate capsule formula was always the goal. The capsule pilot brought encouraging results, but its cost, labor, and potential regulatory requirements make continued production unworkable at this scale. I'm excited to share the new formula!

@catsocialintel Absolutely!

@internetuserf12 I would also say even in mild ME there’s a degree of social death from the outset, being forced to choose between trying to sustain work vs socialising/ building and maintaining relationships.

I'm removing Oxaloacetate due to the price and Glutathione and Dihydroberberine due to their taste. I'm adding creatine, salt, magnesium glycinate, glycine, beetroot, and black carrot. It will be a touch more supportive for folks with dysautonomia without sacrificing a whole lot in terms of mitochondrial support.

@internetuserf12 So it doesn’t have all the same ingredients as APC restore? Can you share which ingredients will not be included so we can source them ourselves?

@jewstein3000 Honestly, that’s the more scientific way to go about adding things anyway. I’m kind of a maximalist to a fault with this blend.

@internetuserf12 I have taken that separately. It once cured my vertigo. However I’m off it now, and taurine. I’m very less is more in gen.

@jewstein3000 I think that removing the Lumbrokinase might improve tolerability for some folks.

@internetuserf12 I think there’s something about me that can’t handle too much at once bc I got worse on the capsules. I know others did well.

I'm assuming folks already know that it speaks 50+ languages because it is, in part, powered by openAI technology through Ultimo Bots in Switzerland.

I just want to confirm that I am improving upon longcovidbot.com every day not just in terms of added literature but also in terms of reasoning. I'm also very open to suggestions.

What distinguishes LongCOVIDbot.com from ChatGPT and Claude is its closed, curated research library and 50 custom behavioral prompts. These act as both guardrails and incentives, organizing the evidence for stronger differential reasoning across diagnoses, treatment approaches, and cross-study synthesis while keeping claims transparent and cited to prevent hallucination(I'm continually improving it). The folks at Ultimo are working with me to scale for more features like persistent conversations and file uploads, launch dates pending. Again, I'm not a fan of AI so I do not take this project lightly and intend for it to be exemplary.

Unfortunately, oenothein B is not very supportive of antigen presenting cell function. mdpi.com/1422-0067/14/1…

Appreciation post for evening primrose(not the oil, but the root). Its constituent oenothein B has been shown preclinically to selectively block PD-1/PD-L1 signaling, reactivating exhausted CD8 T cells and restoring immunity. A plant no one suspected quietly doing immune-checkpoint pharmacology. 💫

@meaniepie11 Yes, I can only infer what properties supplements have in Chinese medicine which is very imprecise.

Chinese medicine is uniquely equipped to unpack complex chronic illness because it doesn't see the body as a collection of isolated organs or disease as a single broken pathway. It sees physiology as a network of perpetuating systems and disease as a network of perpetuating lesions. That framework is remarkably well suited to illnesses like Long Covid where multiple pathological processes operate both independently and interdependently to stabilize the disease state.

@Airborne_Ick The current APC Restore? The ingredients cost $100 and it takes me a week to make a bottle. It was specifically designed for a trial that I am continuing to share for a few more weeks. I don’t have the time or money to keep making it.

@internetuserf12 There’s no excuse for a $100 bottle of supplements

This paper adds another piece to my argument: impaired PBMC mitochondrial respiration during acute COVID-19 predicted greater Long Covid severity three years later. It doesn’t prove bone-marrow persistence, but it supports PBMC dysfunction as a durable downstream signal of deeper immune-system injury - potentially including dysfunctional or reservoir-bearing marrow progenitors. proquest.com/openview/38165…

Remember when we had money to upgrade school HVAC systems and improve indoor air quality which would reduce all airborne illnesses but instead it got repurposed to more police funding because Democrats didnt want to seem like they supported police reform? nbcnews.com/politics/white…

@anti_gyro_ I might incorporate the powder into a formula

@internetuserf12 I only see the oil for sale. Would you buy the loose root powder by itself?