josh kade

GLP-1 people who started semaglutide: what changed first for you that the scale couldn’t show, and what do you wish someone had warned you about before week one?

Retatrutide beats tirzepatide for weight loss, and it’s not close. 24.2% at 48 weeks vs 20.9% at 72. It’s cross-trial, not head-to-head, but more loss in less time is the strongest signal in the category.

Tirzepatide people who hit their goal weight: what happened when you lowered or stopped it, and which part of your maintenance plan actually held up in real life?

being GLP-1 curious is just: what if I regret starting? what if I regret not starting? anyway, back to my 14 open tabs.

Retatrutide beats tirzepatide for fat loss, and it’s not close. Reta hit 24.2% mean weight loss at 48 weeks. Tirz hit 20.9% at 72. Different trials, yes. Still the clearest signal in obesity medicine.

trying to lose weight in 2026: eat protein. walk more. sleep better. then somehow it’s 2am and you have 14 tabs open wondering if you’re behind on peptides.

GLP-1 people who almost quit early: what side effect or rough moment made you question the whole thing, and what happened next that made you stay, switch, or stop?

@RetaDiary Damn, life changing fr

@itsjoshkade The moment I knew it was real was after a stressful day. Normally I’d be looking for food, drinks or some quick dopamine hit. This time I wasn’t.

Retatrutide people, skip the transformation photos. What changed first in your actual day, and what was the moment you knew it wasn’t just expectation?

@sickandtyed 100% makes things so much easier. I know you will too 🙏

@itsjoshkade It was the fact that I knew that there something at the end of the rainbow this time. Before it felt like it would take years for me to look the way I wanted but now I know in a few months I’ll be a brand new person.

@vedichi_ First week Feels like magic lol

@itsjoshkade food noise going quiet, first week in. the moment it clicked wasn't the scale, it was catching myself leave half a plate without deciding to. willpower never did that for me.

tirzepatide myth: weight off means drug off. In SURMOUNT-4, people switched to placebo regained 14% over 52 weeks. Those who stayed on lost another 5.5%. That doesn’t prove “forever.” It proves stopping without a maintenance plan is a gamble.

trying to lose weight in 2026: eat protein. walk more. ignore the GLP-1 FOMO. open 14 tabs at 2am. wonder if you’re disciplined or just behind.

Tirzepatide beats mazdutide on reported weight loss, and it’s not close. About 21% at 72 weeks vs 15% at 48 in separate trials. Mazdutide’s glucagon story is interesting. The scale result still loses.

GLP-1 people who almost quit: what side effect or setback pushed you closest to stopping, and what happened next that made you stay, switch, or walk away?

biggest CJC-1295 myth: DAC and no-DAC are interchangeable. they aren’t. DAC binds albumin. Human trials put its half-life at 5.8 to 8.1 days. no-DAC lacks that add-on, so the exposure pattern is different. “more GH” is not proof of muscle gain.

GLP-1 journey folks, trial results for compounds like Amycretin show big weight loss. What's the *most surprising* thing you've learned about real-world weight loss vs. what trials report?

anyone peptide-curious staying up too late researching the what-ifs

retatrutide beats survodutide for fat loss, and it's not close. 24.2% at 48 weeks vs 16.6% at 76 weeks. survodutide is the liver fat bet. reta is the scale winner.

GHK-Cu gives fast skin changes? mostly wrong. the evidence is mainly topical, small, and slow. collagen remodeling is weeks, not days. injectable claims have far less human data. what would change your mind: photos or controlled measurements?