Jane Lowe Meisel, MD

@MPishvaian @JohnEbbenMDPhD @quirogad @TumorBoardTues @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele Probably so - and membrane permeability also playing a role. Maybe you just need a tiny bit of HER2 expression to have an effect.

@JohnEbbenMDPhD @quirogad @TumorBoardTues @jane_meisel @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele #TumorBoardTuesday And - to follow on @JohnEbbenMDPhD thought - if Tx is efective at that low a HER2 expression level, there must be some very low level of HER2 expression in normal tissue - right❓

🍂@jane_meisel @quirogad are finalizing the upcoming #BCSM #TumorBoardTuesday for 10/03 🌴Join at 8pm ET to discuss CDK4/6i treatment options & breaking updates to ADC use in those with HR+/HER2- met #BreastCancer 🏝️FREE #CME 👉🏽integrityce.com/TBT2023👈🏼

@amybeumer @raffcolo @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 Very true, very true.

@raffcolo @quirogad @TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 Looking forward to seeing the actual data on this study, not just the press release.

@JaniceTNBCmets @MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd I don't think we know yet - but it certainly makes sense that it could! I think this is where trials like SERENA-6 will play a role. Also trials now looking at SERDs as first-line.

@MPishvaian @quirogad @TumorBoardTues @jane_meisel @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd Excellent ? Not relevant in this case, but based on Ph 3 PADA-1 trial, early switch from AI to Fulvestrant + Palbo based on rising ESR1 mut (prior to progression of disease) showed PFS benefit. Could early switch to Elacestrant based on ⬆️ ESR1m provide PFS benefit?

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd @angela_toss Good question. SERENA-6 and other trials out there (camizestrant) are in the works and will try to help answer this! So important.

@quirogad @TumorBoardTues @jane_meisel @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd @angela_toss #TumorBoardTuesday ➡️Right or wrong there is a lot of ctDNA testing out there 🤔If the ESR1 mutation is rarely present at diagnosis, but is more evident as AI resistance clones⬆️would you ever switch to elacestrant early, i.e. before 🩺or🩻disease progression❓

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele I agree: probably low levels of HER2 perhaps hard to detect - but membrane permeability and other features also play a role.

@quirogad @TumorBoardTues @jane_meisel @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele #TumorBoardTuesday 🤔I don't mean to be skeptical - not about the data, but just about the definition of "HER2 non-expressing". There must be at least some HER2 there to function as a🎯for T-DXd, right❓

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @RimapatelMD @jsparano As long as the #research stays ahead of the disease, we can help people live well for a very long time. Exciting times ahead for sure.

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo 16/17 #TumorBoardTuesday 🌅On horizon🌅 💊More anti-estrogen options (SERM, SERD, PROTAC, CERAN, SERCA) 💉More ADC options 🔢Sequencing & personalizing tx approach for pts ‼️🧑🏽‍🔬Need more data/studies🔬‼️ 📚@RimapatelMD @jsparano pubmed.ncbi.nlm.nih.gov/37019913/ pubmed.ncbi.nlm.nih.gov/35008318/

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 #TumorBoardTuesday @PTarantinoMD Tropion-Breast01 announcement for #ESMO23 twitter.com/ptarantinomd/s…

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 15/17 #TumorBoardTuesday #BCSM #BreastCancer 🔥Just announced!🔥 ✨TROPION-Breast01✨ 📍Ph III comparing Dato-DXd to chemo ⬆️⬆️Dato-DXd significantly improves PFS vs chemo 🫁Low risk of ILD 🧑🏼‍🦲potentially less alopecia 🩸less neutropenia 📚@PTarantinoMD twitter.com/ptarantinomd/s…

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 @PTarantinoMD #hotoffthepresses astrazeneca.com/media-centre/p…

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 #TumorBoardTuesday @MartaPerachino twitter.com/martaperachino…

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly 12/17 #TumorBoardTuesday 👩🏽‍🏫Mini tweetorial 9👩🏻‍🏫 🌴TROPICS-02 vs ✨DESTINY Breast-04 📌Sacituzumab govitecan in ER+ MBC 💉Patients pretreated more in 🌴TROPICS-02 📚@hoperugo @stolaney1 @JavierCortesMD pubmed.ncbi.nlm.nih.gov/36027558/ 📚pubmed.ncbi.nlm.nih.gov/37633306/

@stage4kelly @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer @stage4kelly - very exciting! But yes- the 💲💲considerations are so real. That's part of optimizing #communication too - we have to make sure patients feel comfortable sharing concerns about #financialtoxicity just like any other tox!

@quirogad @TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer And thank you for addressing financial considerations. One of the great things about the clinical trial I’m 🤞🏻starting in 2 weeks is I won’t have to pay for the 2 oral meds (similar oral meds would be ~$2000/mo OOP once in Medicare catastrophic coverage)

@amybeumer @stage4kelly @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer I have some patients that do IV fluids/antiemetics on day 4 and day 7 and it helps make the second two weeks of the cycle much more pleasant.

@stage4kelly @jane_meisel @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer For real. Also, I know a couple people who have done well after a few rounds- managing meds to treat nausea etc. Is there a good rec for aggressive SE treatment right off the bat?

@stage4kelly @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer So true. Dose reductions, spacing out treatment, and fluids/antiemetics can help - but there's no denying it is not a walk in the park.

@jane_meisel @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer Too bad there’s so much 🤢 with TDxd the holy grail is efficacy AND good QOL

@JohnEbbenMDPhD @RenoHemonc @MPishvaian @quirogad @TumorBoardTues @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD SO challenging - though the field moving fast is a good problem to have. Makes real world data that much more important!

@RenoHemonc @MPishvaian @quirogad @TumorBoardTues @jane_meisel @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD Valid point...wonder if the study started before this was SOC? Recognize that it's hard with trials now to design given that SOC shifts frequently (for the better)--how can we do trial design better? #TumorBoardTuesday

@esrajustesra @quirogad @amybeumer @TumorBoardTues We don't know a lot about this, because MAINTAIN was mostly ribo after palbo - but in the right patient with slow progression, it would not be unreasonable in my mind to do this and watch closely!

@jane_meisel @quirogad @amybeumer @TumorBoardTues What about ribo after abema?

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD A total of 165 patients received fulvestrant, and 73 received an aromatase inhibitor - so the majority received fulvestrant but it was a mix!

@quirogad @TumorBoardTues @jane_meisel @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD #TumorBoardTuesday Here the difference in outcomes in patients who received SOC is not that much - did most of the SOC patients receive fulvestrant?

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer You can imagine there may come a time when T-Dxd could be an option for all patients, regardless of HER2 status...

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer 9/17 #TumorBoardTuesday #BCSM #BreastCancer 👩🏽‍🏫Mini tweetorial 6👩🏻‍🏫 ✨DAISY✨ 📌T-DXd in HER2-zero MBC 📍Ph II single-arm 🔹T-Dxd for MBC for all levels of HER2 expression 💉>1 line of prior chemo 📈n=37 pts with HER2 zero MBC ➡️ ORR 29.7% @MeganTesch

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer #TumorBoardTuesday @hoperugo #ESMO21: twitter.com/hoperugo/statu…

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer 8/17 #TumorBoardTuesday #BCSM 👩🏽‍🏫Mini tweetorial 5👩🏻‍🏫 ✨DESTINY-Breast 04✨ 📌T-DXd in HER2-low (+1, +2, neg FISH) MBC 📍Ph III comparing T-Dxd vs 👨🏾‍⚕️ choice chemo 💉1-2 lines of prior chemo 📈Vast improvement in PFS and OS in HER2-low pop 📚#ShanuModi nejm.org/doi/full/10.10…

@stage4kelly @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer So important, @stage4kelly: thank you for highlighting this!

@quirogad @TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer And remember to ALWAYS discuss clinical trial options with ALL patients - no assuming someone won’t want to participate in a trial!!

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer cancer.org/cancer/managin…

@TumorBoardTues @jane_meisel @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi 7/17 #TumorBoardTuesday #BreastCancer @fumikochino @stage4kelly @MammaMiaMagazin @amybeumer 👩🏽🤝👩🏻‍⚕️ 🗣️Discuss all chemo options with patient and family‼️#SharedDecision 🤔What fits with patient goals and QOL? 💸Other costs of tx: time, financial, physical 📚@AmericanCancer

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer SO important. Honest conversations between patient and doctor can almost always get you to the right decision for that moment in time.