Jay Iyer

In this secondary analysis, we examined associations between concomitant medications and #PSP Rating Scale scores. We observed that participants prescribed benzodiazepines experienced more rapid worsening compared to those not prescribed benzodiazepines. @CurePSP @MGHNeurology

My best friend @jaymiyer is running the 2025 BMW Berlin Marathon to raise money for @CurePSP and support Progressive Supranuclear Palsy (PSP) patients. In 2019, PSP claimed the lives of both Jay’s grandfather and my grandmother. Please consider donating: give.curepsp.org/fundraiser/641…

Very grateful to be a part of this work, mentored by @sachinjshah. Here, we identify a subgroup of patients for which AF screening is effective, and show that effect-based screening approaches should be used with risk-based approaches when screening for atrial fibrillation.

From a backyard garden in Louisiana to research labs at @MassGeneralNews, @jaymiyer's journey began with his grandfather, Mani, who sparked his love for science. After Mani’s battle with PSP, Jay now researches new treatments, hoping to bring hope to others affected by rare neurological diseases. #PSP #Neurology Read more: mgriblog.org/2024/10/11/mas…

Wonderful to attend #Neuro2024 in Toronto. Thank you @CurePSP @UHN for organizing an incredible meeting and bringing together the world’s leaders in #PSP and #CBD as we all work towards a cure.

@ayushnoori 5-6 in every 100,000 brought us together—your friendship means the world to me, Ayush. Seeing your work-ethic and dedication every day inspires me to keep pushing forward. Let’s keep working to improve neurological care together 🙏🏽❤️

Please consider reading the story of @jaymiyer, my best friend at Harvard, and his brave and loving family. Jay and I were fast friends in part because of many parallels in our life experiences. It's been inspiring to watch him use his personal adversity as fuel for his fire.

Thank you @MGH_RI for sharing my family's story. I'm incredibly grateful to have the opportunity to learn and grow under wonderful mentors at @MGHNeurology. mgriblog.org/2024/10/11/mas…

Researchers from @MGHNeuro and colleagues find that benzodiazepines are associated with worse disease progression in Progressive Supranuclear Palsy, in a @JAMANeuro study. doi.org/10.1001/jamane…

In a recent @JAMANeuro publication, researchers from @MGHNeurology and colleagues found that benzodiazepines are associated with worse disease progression in progressive supranuclear palsy. Read more: massgeneral.org/news/research-…

Last summer, I had the incredible opportunity to conduct research in the Shimogori Lab at @RIKEN_CBS, focusing on analyzing spatial transcriptomics of the developing marmoset thalamus. It was a wonderful experience and I hope to visit again soon!

Are we causing harm to progressive supranuclear palsy (PSP folks) by prescribing them benzodiazepines? Seems logical and now we see some 'stunning' preliminary data from a recent clinical trial @JAMANeuro by Iyer, Boxer, Wills and colleagues. Key points: - Participants in this clinical trial prescribed benzodiazepine derivatives 'experienced more rapid worsening in the PSPRS score between weeks 26 and 52.' - The authors controlled for 'potential confounders.' - There didn't seem to be a bias in the types of persons in each comparison group arguing against rapid progression subtypes affecting. -Duration and dose not associated w/rate of change in scores. Could it be small sample size? My take: The Davunetide clinical trial enrolled only the Richardson syndrome subtype of PSP so we should be careful not to generalize findings, unless and until we have more data. PSP cases are frequently divided by experts into subgroups: PSP–Richardson: classic subtype, PSP–parkinsonism w/ some levodopa response (particularly early in disease), and a Pure Akinesia and Gait Failure subtype. We should 'think twice' before prescribing 'benzos' in PSP. Primum non nocere, first, do no harm. jamanetwork.com/journals/jaman… @CurePSP @DenaDubal @samplease @cynarmandmd

This is important and clinically relevant work out now in @JAMANeuro, from @MGHNeurology @CurePSP and led by the brilliant @jaymiyer. This secondary analysis revealed that progressive supranuclear palsy (PSP) patients prescribed benzodiazepines show faster clinical decline. 1/2

The past year has been a difficult road and an emotional journey as I've battled PSP. But right now, what I feel most is hope. Thank you to my friend @RepMcClellan for sharing my words on why Congress must take action to pass the bipartisan National Plan to End Parkinson's Act.

Great to present our work on validating genetic variants associated with motor and nonmotor progression of #Parkinsons at the PSG/PF meeting!

🌟 Happy #GivingTuesday! 🌍 Today, we're sharing our community's inspiring stories of resilience on CurePSP's Facebook and Instagram. Follow along, connect with us, donate and join the movement of making a positive impact! give.curepsp.org/campaign/2023-… #BecauseHopeMatters

Next Wed, Nov 15th, hear from Dr. Anne-Marie Wills, the director of one of our CurePSP Centers of Care and a leader in the field of research and care for PSP, CBS/CBD and other neurodegenerative diseases. @MGHMedicine

We are thrilled to be a part of this exciting game day news! #HealeyHope #TackleALS

Patients with #PSP need to be sooner and more frequently. ⚡️Senior author⚡️on an important POV manuscript with Marian Dale of @OHSUBrain, @FarwaAli_, @KristopheDiaz and many others from @CurePSP Centers of Care. Out now in @ParkinsonismD! sciencedirect.com/science/articl…

@ec_bayram Thanks for all of your help and support with this project, Ece!

i'm late argh. if you got check out Jay's work at neuro2023, lucky you, BUT if you didn't get a chance to check it out, you need to follow him to find out more!

Wonderful to attend #Neuro2023 in London! Thank you to @CurePSP and @PSPAssociation for organizing and inspiring collaboration.