Jackson Cahn

The current crop of AI scientists is over-indexed on doing things scientists enjoy (eg. ideation) instead of things they hate (eg. data cleaning) Don't make your AIxBio product a restaurant where the customers cook their own food and your value proposition is to eat it for them

This week's Biotech Scorecard newsletter: The old Vinay Prasad never left. He just changed jobs Submissions to the FDA are handled by teams of reviewers, of course. But when I look across all of these recent cases, I see a consistent throwback to the old Prasad — questioning the legitimacy of biomarkers, surrogate endpoints, and single-arm clinical trials, even in the setting of rare diseases. In some of these rare-disease drug rejections, Atara $ATRA and Regenxbio $RGNX are good examples, Prasad or the staffers he directs aren’t following the agency’s own guidance. Companies are told early that their clinical development programs meet FDA requirements, but then, almost arbitrarily, the FDA changes the rules. Uniqure $QURE and its gene therapy for Huntington’s disease have been in a holding pattern for months because guidance it received long ago from the FDA is now, under Prasad’s watch, null and void. Read more at link below...

What a fuckshow

@malikules "sure it was all fake but she raised big" Can't think of a better self-parody of SV culture

@jkbcahn despite all of her wrongdoings, she did raise $700M in 2013, which is nuts

we're going to revolutionize the [industry] by partnering with [incumbent] and having [tenured scientists who haven't done firsthand research in 2-3 decades] lead this project to beat competitors led by 23yo agency-pilled builders who don't need food, sleep, or social life to keep doing what they're doing yeaaaa, sounds about right

I haven’t stopped thinking about the Super Bowl and I just gotta say something. If we play them 100 times I think we win 46 of them.

@dennisbhooper "school shooting"

So c*nt and f*g have way different velocities in American English vs. British, with the latter having an almost entirely separate meaning, and are both way more offensive to Americans. But is there an inverse to this, a casual American expression that horrifies English people?

Patriots have Christian Gonzalez and Seahawks have 15 dudes playing as well as Christian Gonzalez

they dragged her away in chains and shipped her to Texas and only then checked, determined she was in fact here legally, and released her in Texas to figure out how to get back to Minnesota herself. and people wonder why her neighbors would protest!!!

"Terrible things are happening outside. Poor helpless people are being dragged out of their homes. Families are torn apart. Men, women, and children are separated. Children come home from school to find that their parents have disappeared." Diary of Anne Frank January 13, 1943

signs left at alex pretti’s memorial in minneapolis: “i love you so much / i’ll miss you forever” photo with a friend, “i would have done the same. RIP alex,” a stethoscope and “we’ll take it from here, alex” and a tshirt for the minnesota nurses association

Listen. You don’t interfere with the duties of armed officers of the government. That’s just asking to be killed.

"Who would bring a gun to a protest?" mfs when they're the ones protesting

A mom who wrote poems, a preschooler with a Spider-Man backpack , a nurse who cared for veterans — these are the people they’re afraid of.

"The Party told you to reject the evidence of your eyes and ears. It was their final, most essential command." ― George Orwell, 1984

Alex Pretti, the man killed by federal agents today in Minneapolis. appears to have been a registered nurse, an athlete, a son and a brother, with ties to Colorado and Wisconsin. Here is a photo he used for several accounts.

“wHaT RaDiCaLiZeD yOu?” idk, im not a piece of shit

@RajaKorman Bravo 👌

There can be no clearer evidence that the White House believes in a Unipolar world.

Trump is halfway finished with his term. The midterms are in a few months. He only has 2 years left. All that Europeans and Canadians have to do is wait and be nice to Trump. And that’s it. But no, they are immediately selling everything to China. China china china. Idiots.