Mac Shine

New review paper out today in @NatureNeuro with @DrBreaky, @eli_j_muller, @DrBMunn, @rosalynjmoran and @Joana_Cabral__, based on a symposium that we hosted at @OHBM in 2019 on the importance of the neuromodulatory arousal system for shaping whole brain dynamics (1/n)

Thanks to all our wonderful Mentors!! Nicola Palomero-Gallagher, @Forough_HaS, @sofievalk, @choongwanwoo, @jmacshine, @AFornito, @tonyajhwhite, @emilyjacobs, Ruchika Prakash, @Joana_Cabral__, @HelenJuanZhou, @medelero, Xujun Duan

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala rdcu.be/el19t nature.com/articles/s4158…

🎉 FINALLY PUBLISHED! 🎉 We outline how to capture the #emergent dynamical structure in #biophysical neural models. coauthored with a team dear to my heart; Thomas Andrillon, @anilkseth, @LionelBarnett2, @OCarterUoM @PLOSCompBiol journals.plos.org/ploscompbiol/a…

Do you have a plan for management of freezing of gait (FOG) in Parkinson's? I think about 5 things when constructing a PLAN. Check out the new paper by Tosserams, Fasano, Bloem, Nonnekes and colleagues in Nature Reviews Neurology. Key Points: - Freezing of gait is one of the most disabling symptoms in Parkinson’s. - It is one of the most frustrating for patients and caregivers alike. - People may describe it as feeling like their feet are glued to the floor, and FOG increases fall risk, anxiety, and loss of independence. My Take: I urge our community to take a step forward with more coordinated plans for FOG in Parkinson's. FOG in Parkinson’s: Why do we need a plan? This paper offers us a clear, comprehensive, pathophysiology-driven framework to build a person specific plan. An important point that resonates for me: FOG isn’t one thing, it’s many things. It demands listening, with a personalized, evolving approach. It must addresses motor and non-motor factors that may underpin the manifestation. Here are 5 key things I consider when treating freezing of gait (FOG): 1- Classify the type of FOG – Is it OFF-state, pseudo-ON, or dopamine-unresponsive? Your treatment will hinge on this. 2- Optimize dopamine – Tailor medications carefully, and consider infusion or DBS if or when appropriate. 3- Use non-drug strategies – Physical therapy, cueing, and gait training. These can be powerful, especially early in disease. 4- Treat the whole person. Anxiety, cognition, and sleep all interact with FOG. Addressing these features matters. 5- Think prevention: Exercise, balance training, and early identification. Can we delay FOG or treat the person more effectively so it does not emerge? Listen and optimize plans at every visit even if FOG is not present. Let’s turn these insights into action. BRAVO to the authors. Don't be nolens volens – willy-nilly about freezing of gait (FOG). nature.com/articles/s4158… #Parkinsons #FOG #FreezingOfGait #Neurology #DBS #Gait #MovementDisorders #ParkinsonsPlan #NeuroRehab #NeuroInnovation @ParkinsonDotOrg @FixelInstitute

Mac Shine @jmacshine talks with Michael R. Bruchas about new research suggesting that pericoeruleus neurons act as a sort of controller or filter on locus coeruleus activity. thetransmitter.org/attention/the-…

Learn about the latest findings reported @Nature on brainstem cells that fine-tune arousal. Watch video interview with Michael Bruchas @UWAnesthPainMed @UWPharmacology @UWBioE with @_TheTransmitter host @jmacshine tinyurl.com/5fe4s232

New paper in Imaging Neuroscience by Isabella F. Orlando, Claire O’Callaghan, et al: Dopamine alters functional gradients in Parkinson’s disease doi.org/10.1162/imag_a…

Applications for our postdoc position closes in 6 days! (Deadline: May 18 11:55pm AEST) If you are interested in MRI, modelling of brain dynamics, and genetics in health, disease, or across evolution, we would love for you to join our team👇👇

Come meet @camri_unc members during @ISMRM! On Saturday (May 10) at the @bruker event and Monday (May 12) at 14:01 in the fMRI power pitch session, @TzuHaoHarryChao will talk about his work mapping inter-brain functional connectivity in socially interacting mice using SORDINO.

@PiantadosiSean @mbruchas @Nature @aluskin @dilithium21 Thanks for tagging the team that did the beautiful work!

great and wide-ranging interview between @mbruchas and @jmacshine, centering on the Bruchas lab's recent @Nature paper from co-first authors @aluskin and @dilithium21. check it out!

I recently had the great pleasure of interviewing Michael Bruchas about an absolutely banger recent paper from his group that tracked down cells in the brainstem that subtlety and precisely control the output of the locus coeruleus. Check out my interview here!

Please chk out the lab's newest paper, a labor of love it was. From @aluskin & @dilithium21, w/ @madisonmartin @Braininajarr @mouse_braind @GoldenNeuron @gstuber & others. We report a new road map for the LC-NE & peri-LC systems. Thx @NIMHgov @NIDAnews nature.com/articles/s4158…

New paper on arousal in the brain! What controls the controller?

Big congrats to @aluskin @mbruchas et al., on their paper on circuits controlling LC neurons. Lots of interesting data on the peri-LC cell types, connectivity, and function to dig into here.

We pay people to quit their jobs, and start fighting the world’s biggest problems instead. Not someday. Not later. Now’s the time. Already, 20+ people across Europe have made the leap. Because the truth is: The world doesn’t just need more brilliant minds. It needs brilliant minds on the right side of history. 📢 EU Fellowship applications close May 12th.
🌎 Global (including U.S.) applications are now open and close soon. moralambition.org/fellowships/al…

Check out the new Q&A with Kempner associate faculty member Sam Gershman to get a glimpse of his research on biological intelligence — including some exciting work on non-synaptic learning! bit.ly/KempnerGershman @PsychHarvard @gershbrain #neuroscience #psychology #cogsci

First tweet on an exciting new manuscript online @NatureNeuro - in collab with @LucinaUddin and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠... #neuroscience #neuroimaging #fMRI Read here: rdcu.be/ek01F

👀Brainstem atlas animation 👀 Using high-quality @NIH Human Connectome Project data, we previously built a probabilistic map of 23 major brainstem fiber bundles—overcoming distortion issues that plagued past studies. It's publicly available for all: bit.ly/44kQFuy 🧠🔬

Basal ganglia output is a formidable bottleneck Striatum neurons project to output nuclei in a ratio ~16:1; but their targets outnumber them by up to 150 to 1. New paper on how I got to those numbers & the model of basal ganglia output they imply eneuro.org/content/12/4/E…

🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI) + a guide to create your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊 anniegbryant.github.io/subcortex_visu…