John Lees

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John Lees

John Lees

@johnlees6

Pathogen informatics and modelling https://t.co/2Qg0pvaFg3 (Research group leader at EMBL-EBI - https://t.co/lJdwj0idt0)

Katılım Aralık 2009
602 Takip Edilen1.4K Takipçiler
John Lees retweetledi
EMBL
EMBL@embl·
Have you ever thought of doing a sabbatical at EMBL? It’s a great opportunity for scientific exchange and growth, and for learning advanced technologies and top-notch science! Three scientists shared their experiences on their research visits at EMBL. 👇 embl.org/news/connectio…
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Timo Saratto (Moilanen)
Timo Saratto (Moilanen)@TimoSaratto·
A cool upcoming feature: When you upload a sample to Solu Platform, we’ll search all public NCBI samples for related genomes. This is built on the awesome AllTheBacteria database by Martin Hunt, Leandro Lima, @shenwei356, @johnlees6 & @ZaminIqbal
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Roli Roberts
Roli Roberts@RoliRoberts·
This neat paper about rapid evolution of bacterial transformation rate by @eprocha @labXC & co takes some of its inspiration from an earlier @PLOSBiology paper by Nick Croucher & @ChristoPhraser: journals.plos.org/plosbiology/ar…
PLOS Biology@PLOSBiology

Why do #bacterial species' #TransformationRates vary so dramatically? @epcrocha @labXC &co show that #Legionella & #Acinetobacter transformation rates evolve by sudden changes, likely caused by conflicts between #MGEs and the host bacterium #PLOSBiology plos.io/4dMviTR

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Zamin Iqbal
Zamin Iqbal@ZaminIqbal·
Daria Frolova's paper in plasmid relatedness now out in MGen! She uses rearrangement distances & shared seq content to build a relatedness network of plasmids, identifies hubs which are likely transposons, and then clusters related plasmids. microbiologyresearch.org/content/journa… @MicrobioSoc
Zamin Iqbal@ZaminIqbal

First paper from my student Daria Frolova's PhD now on biorxiv: biorxiv.org/content/10.110… The key question: plasmids change structurally ~as fast as they mutate, so how can we decide whether 2 plasmids are "the same plasmid" for epi purposes? 1/n

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John Lees
John Lees@johnlees6·
Extension to ska 'skalo' -- using local assembly to recover indels and MNPs where split k-mers mismatch biorxiv.org/content/10.110… We hope to integrate this into the main ska package in future too
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Camille Marchet @CamilleMrcht@genomic.social
I'm looking for a know fusion signature in a graph that contains annotated human transcripts (from Refseq) and samples, including prone to fusion (human carcinoma samples).
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John Lees
John Lees@johnlees6·
There is still time to register for our SMBE satellite meeting on pangenomes and transmission in Tokyo (until 31st October) See our website for more details, and now a provisional schedule too! smbepangenomes.bacpop.org
John Lees@johnlees6

We are happy to have been selected by SMBE to host a satellite meeting on Pathogen Pangenome Evolution Between and Within their Hosts: smbepangenomes.bacpop.org We are expecting the meeting to be in Tokyo on 26-28th November 2024, save the date!

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John Lees
John Lees@johnlees6·
Also now old Celebrimbor is a big name in rings of power s2 maybe our backronym will finally land
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John Lees
John Lees@johnlees6·
Sam has then wrapped it all up in a nice snakemake pipeline CELEBRIMBOR (Core ELEment Bias Removal In Metagenome Binned ORthologs) which lets you go from MAGs to pangenome github.com/bacpop/CELEBRI…
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EMBL Events
EMBL Events@EMBLEvents·
📢 Only a week left to submit your abstract for #EMBLInfectionBiology 🦠 The event is a platform for late-stage postdoctoral scientists in infection biology to connect with the leading European institutions in the field. It is fully virtual for the ease of access 💻 Discuss your research and network in a friendly setting to step up your career! 🧑🏻‍🔬🫱🏾‍🫲🏻 📜 Submit your abstract by 15 Sep ➡️ s.embl.org/inb24-01
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John Lees
John Lees@johnlees6·
A reminder that abstract submission for the SMBE satellite meeting on pathogen pangenomes and transmission closes soon (8th September, a short extension). See: smbepangenomes.bacpop.org
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John Lees
John Lees@johnlees6·
I have written up some new notes in the intermediate programming course on parallel programming, which are available here: iprogramming.bacpop.org/parallel.html The main intro and advanced examples are in rust, but I've also added two independent sections covering python and R.
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John Lees
John Lees@johnlees6·
@yatishturakhia Yes very exciting stuff! Looking forward to seeing where you take it
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Yatish Turakhia
Yatish Turakhia@yatishturakhia·
@johnlees6 Thank you for your insightful and fair review of our work! We have taken note of this and are working on addressing the valid concerns you have raised.
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