Juan Pablo Unfried

567 posts

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Juan Pablo Unfried

Juan Pablo Unfried

@jp_unfried

LncRNAs and genome regulation enthusiast @azrielifdn & @EMBOFellows Postdoc in @IgorUlitsky Lab @WeizmannScience 🇨🇷🇪🇸🇮🇱

Rehovot, Israel Katılım Eylül 2020
496 Takip Edilen254 Takipçiler
Juan Pablo Unfried retweetledi
Anders Sejr Hansen
Anders Sejr Hansen@Anders_S_Hansen·
(1/n) Super excited to share that our preprint is out today in @NatureSMB with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: nature.com/articles/s4159… MIT NEWS: news.mit.edu/2026/how-chrom…
Anders Sejr Hansen tweet mediaAnders Sejr Hansen tweet media
Anders Sejr Hansen@Anders_S_Hansen

(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers biorxiv.org/content/10.110…

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Juan Pablo Unfried
Juan Pablo Unfried@jp_unfried·
The more we know about both the more lncRNAs and transcription converge. This took a while but very happy with how it turned out. Public full text view access here: rdcu.be/fgqIb
Igor Ulitsky@IgorUlitsky

🆕 review with @jp_unfried out in @NatureSMB 🧐. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? nature.com/articles/s4159…

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Juan Pablo Unfried
Juan Pablo Unfried@jp_unfried·
Sounds like a decision from a group of people who is tired, overworked and underfunded... which does not help how bad this is for science and how far from a "solution"... but I feel sympathetic for the people.
European Research Council (ERC)@ERC_Research

The number of grant applications is rising sharply. Our capacity for their evaluation isn’t. ERC President Maria Leptin explains why stricter resubmission limits are being introduced for 2027 calls and what this mean for applicants. link.europa.eu/xF7kjc

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Igor Ulitsky
Igor Ulitsky@IgorUlitsky·
Where do you host the bigWig/bigBed files for your UCSC genome browser hubs? (pro-Iran hackers thought that our "nuclear RNA-seq" track data was, well, *nuclear* and yada yada yada we need a new server)
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Igor Ulitsky
Igor Ulitsky@IgorUlitsky·
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…
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David R. Liu
David R. Liu@davidrliu·
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfku5j…
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Gabrijela Dumbović
Gabrijela Dumbović@Gabrijela_D·
Our lab is expanding! We are looking for an experimental or computational PhD student and a Technical Assistant for a project on RNA localization regulation. Details 👉 shorturl.at/fWH3u ⏳ +1 more PhD spot still open—10 days left to apply! shorturl.at/Udw0Q #PhD
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Igor Ulitsky
Igor Ulitsky@IgorUlitsky·
I'll be in Boston/NYC/UPenn for <72 hrs this week explaining why @WeizmannScience is the best school there is. If you know anyone that it can be relevant for - please DM me for details.
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Stricker Lab
Stricker Lab@LabStricker·
Let's do CRISPRa without virus and plasmids!!! Congratulations to Tobi and all the authors ! It was a really fun project, revealing some exciting results! academic.oup.com/nar/article/53…
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Molecular Cell
Molecular Cell@MolecularCell·
Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens dlvr.it/TJNjwL
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Feng Zhang
Feng Zhang@zhangf·
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/sc…
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Keşfet

@NatureSMB @CellCellPress @bloodgenes @hhmi_science @BostonChildrens @US_FDA @kiranmusunuru @ScienceMagazine