Jigar Raythatha

@RaajitRampal @MSKCancerCenter @MSK_DeptOfMed @pankitvachhani @mpdrc Thanks Raajit for you commitment to MPN patients and pelabresib! Hope you are well!

Excited to present updated data on MANIFEST-2 phase III trial at #ASCO24 . My first time speaking (haven’t said that in awhile) at ASCO in 15 years in Heme/Onc. Looking forward to lively discussion . @MSKCancerCenter @MSK_DeptOfMed #mpnsm @pankitvachhani @mpdrc

@elonmusk I dropped my car off to address a creaking noise from the trunk on 12/21. Full month later and no estimate on when I will have it back.

The OG #MPNLegend ⁦@harrisoncn1⁩ presenting 1L MANIFEST data (Pelabresib + Rux) with 68% SVR35 and 57%TSS50 and good data in add on cohort. MANIFEST 2 Phase III accruing #EHA22 ⁦@jjkiladjian⁩ ⁦@doctorpemm⁩ ⁦@AaronGerds⁩ #mpnsm ⁦@UTHealthSAMDA⁩

@JMaraganore Thank you for being a wonderful example and a great mentor over the years!

And so, my friends, it’s a wrap! Leaving Alnylam as CEO for the last time. The last 19+ years have been epic. Thanks to all my colleagues and supporters!

@JebKeiper @NimbusTx Congratulations @JebKeiper and the @NimbusTx team!

Thrilled to welcome many new investors into this round of financing! Confirmation that @NimbusTx capabilities/ plans/ people will drive our allosteric TYK2 through multiple Ph2 studies in PsO and other indications,

@LifeSciVC Wonderful reflection indeed! Love how we all compete and collaborate at the same time.

@jraythatha Of course! A great team that advanced several promising drugs! And a wonderful reflection of a positively interconnected ecosystem.

So sales of Janssen’s Tremfya are buying Constellation via Morphosys, brokered by Royalty Pharma, for BET & EZH2 drugs discovered in work funded by Genentech, informed by patents from GSK Gotta love the interconnected universe of biopharma $JNJ $CNST $MOR $RPRX $DNA $RHHBY $GSK

@elonmusk @MonicaLewinsky Can I get the same deal? Bringing my Model Y for service for 3rd time this week. I have owned it less than 3 weeks.

@MonicaLewinsky Try a Tesla & you’re welcome to give it back if you decide you prefer a Subaru

so very me. can’t decide between a subaru or a tesla.

@elonmusk driving my brand new Model Y but vry disappointed with finishing. Passenger door runs against fender and your service team can’t seem to fix. They also keep the car for multiple days without providing a loaner. Can you help?

@markagoldsmith1 @ChrisCuomo @CDCgov @NIH @Surgeon_General @WhiteHouse Good point Mark! Also - prioritizing testing more mild/asymptomatic people will stop inadvertent spread.

@lexingtonsuper @lexingtonsuper really want commend you and your colleagues for taking action. It’s hard, but the right thing to do. #WorkingTogether

NO SCHOOL TOMORROW. In collaboration with several of my counterparts, Lexington Public Schools will be closed tomorrow and at minimum for the next two weeks. More information to follow.

Thanks you @bprosek11 - Right back atcha! @CPI_epigenetics

2/2 Nor could I imagine good fortune ahead to work w/ friends&leaders like @jraythatha. Listening to Jigar’s @ldtimmerman talk on @CPI_epigenetics Long Run to deliver RX reminds that this jam is not full of Massholes, rather people trying to make a difference in patients lives.

@megtirrell my wife once sent me a picture of a handful of chocolate chips that our kids left in her purse as a gift 😂. Really “sweet”!

When you’re about to leave on a work trip and find this in your pocket 😭

Impressive talk by Jacob Stuckey of @CPI_epigenetics at #DDSEU19 about optimizing residence time of EZH2 inhibitors. Leading to a compound where in vivo efficacy studies are faster than accurate measurement of biochemical kinetics data...😱 @drugdiscovery1 @OGConferences

@SGottliebFDA @realDonaldTrump @senatemajldr @SpeakerPelosi Our Sickest patients being deprived of treatment. Please end this silly squabble

Another pro tip: a little shabby, but the second floor of the Jack in the Box next to the Westin has no table cover charge, plenty of space for meetings. From humble beginnings great outcomes are possible. #JPM19

RT for your chance to throw out a first pitch at a game and get four tickets so your friends and family can see it! #Mets25DaysOfGiving Rules: atmlb.com/2EM0ztu

RT for the opportunity to win lunch with #Mets COO Jeff Wilpon! (We’ll pick multiple winners) #Mets25DaysOfGiving Rules: atmlb.com/2GAnlqG

@barnesbloomberg, Tom Moroney, Pat Carroll Thanks for having me on your show. @CPI_epigenetics #brightertogether

@nickhaining @Merck @DanaFarber @broadinstitute Congrats Nick! You will be great.

So, a spot of news: delighted to say I’ll be starting as VP, Oncology @Merck in Jan. Very sad to leave phenomenal colleagues and trainees @DanaFarber & @BroadInstitute yet thrilled to be leading a world-class team discovering medicines for the people who need them most.