John Slater

@sarabollman I tend to agree with this. While I believe dark nights happen in which people come out the other side better off, I also think there are plenty of people who trudge deeper into worsening mental health, continuing with a practice that is likely harming them.

@kennytjay @dmccarthy7 @grok I think @grok might be be wrong on this one - as someone who has gotten more than his fair share of street sweeping tickets in SF, they are $105 each. $105 x 540,000 =$56,700,000.00 from street sweeping alone

@dmccarthy7 @grok how much revenue does 540,000 parking tickets bring in annually for the city?

San Francisco issues ~540,000 parking tickets per year specifically for street sweeping violations (more than one per year per car registered in the city), but that’s the price you gotta pay for sparkling-clean streets

@bitcoinpanda69 @bryan_johnson He didn't start experimenting with very high heat to truly activate heat shock proteins until the last month or two if I'm not mistaken, so it seems the benefits of sauna on this virtually all occurred at the lower heat.

@bryan_johnson Congratulations man that is very cool Please answer this question, since I am sure many would like to know Your sauna is very high heat Would a 160 degrees max sauna still yield results? Do you know if it's the sweat itself, or if it has something to do w heat shock etc

🚨 I HAVE NO MICROPLASTICS IN MY BALLS 🚨 This should not be possible. Studies show that 100% of men have microplastics in their semen. I am the first human ever to show a complete reduction to zero. This may be a world-first breakthrough in fertility research. I had 165 microplastic particles in my semen just 18 months ago. Now, I have zero. Five published studies have measured microplastics in human semen. Two found them in 100% of men. The other three found then in 44 to 76% of men tested, but those used methods that miss the smallest particles and the clear ones. Corrected for that, the real rate is likely 100%. Almost every man alive has plastic in his semen right now. The same applies to testicular tissue, testing 100% positive for microplastics. Microplastics hurt sperm. Human studies show the impact of various types of plastic, associated chemicals, and other toxins on male fertility: + 60% fewer normal shaped sperm (from PFAS) + 5x higher odds of low sperm count (from PTFE) + 10% lower sperm concentration (from PTFE) + 15% lower swimming ability (from PTFE) + 41% lower swimming ability (from PET) + 12% lower sperm swimming ability (from BPA) + 3x higher odds of low sperm count (from Phthalates) + 2x higher odds of poor swimming (from Phthalates) The effects compound: each extra type of plastic drops sperm swimming ability by about 21%. This matters even if you’re NOT trying to get pregnant. Sperm count is one of the cleanest biomarkers of overall health we have. And microplastics don't stop at the testes. The same particles are showing up everywhere we look. Studies show 4.5x higher rate of heart attack, stroke, and death in people with microplastics in their arterial plaque vs. those without. Microplastics were also found in 100% of human placentas tested. 100% of post-mortem human brains tested positive for microplastics. Brain concentrations rose ~50% between 2016 and 2024, and now sit at roughly 11x the levels found in the liver or kidney. Where do these come from? + PTFE, commonly in non-stick pans + PET, water bottles + Phthalates, makes plastic soft and bendy + BPA, can linings + PFAS, stain-resistant fabrics & food packaging Inside the body, plastic causes a kind of cellular rust. It triggers inflammation in the testicles, kills the cells that make sperm and drops testosterone. It's been confirmed across 39 animal and cell studies, then in human data. MY PROTOCOL: Note, what I did is n=1, not a controlled trial, I cannot prove cause. 1. Sauna (dry). My toxin blood panel confirms sauna clears plastic related chemicals: BPA, phthalates, PFAS, flame retardants, pesticides. The plastic particles themselves are too big to sweat out directly. Heat may activate other clearance routes: bile flow through the liver, the cell's internal cleanup system, and the gut barrier. Humans have almost no enzymes that can break plastic apart, so the body has to physically push it out. 2. Reverse osmosis water filter. Drinking water is likely a major source of microplastic getting into your body. A reverse osmosis filter pushes water through a very tight membrane and strains the particles out. I filter everything I drink. 3. Trying to rid my environment of the big plastic items: cutting boards, cups, plates, food storage containers, non-stick pans, cling wrap, tea bags, water bottles, kitchen utensils, kettles, and synthetic clothing. Note, as hard as I try, I'm always finding new plastic things in my life. This can be all-consuming thing so try to just knock out the big ones. I did all three interventions at the same time. I cannot say which one did the most work. What I can say is this: going from 165 to zero in 18 months is possible. Results: Nov 2024: 165 particles/mL Jul 2025: 20 particles/mL Apr 2026: 0 particles/mL The 18 month window also captures roughly 7 full spermatogenesis cycles.

@iphone15pormax @BLCNYY For sure! I usually use the mic anyway as that gets best of both worlds - voice dictation + SOTA model

@jslater92 @BLCNYY hopefully we get a proper voice mode on codex that would be really cool

After using GPT-5.5 instant inside ChatGPT for almost a day, I can confidently say that this is a way bigger jump than we all thought. It features a new and better personality with the level of intelligence we have never seen before with any model that fast. Along with the new voice mode coming hopefully this week, the entire ChatGPT experience will change from the ground up for everyone. Get ready for an AI experience that understands you, takes actions on your behalf, and is both fast and incredibly smart at the same time. We are accelerating, and there is no wall.

@iphone15pormax @BLCNYY They’ve been using 4o for roughly two years for voice mode. The text models have been way better for awhile. This will be a big shift for the masses who use voice mode for a lot of their usage

@BLCNYY the voice model has been terrible so hopefully they make it closer to 5.5 instant. i’m not too sure how different the voice vs text models are on the backend but there is a noticeable quality difference between them

You’re right there should be zero tolerance, but man, things are moving in the right direction in SF. The data all points to this. It unfortunately can’t be fixed overnight, even with much improved policy. Yes, it’s tragic to see these sights, but broadcasting 2020-23 talking points as if there hasn’t been any change since then just isn’t the truth. Lurie has moved the needle on this issue in the right direction.

San Francisco politicians and their constituents enable this suffering. They are the cause of it, because they can stop it instantly. Today, tomorrow and every one of the last 1,000 days this has happened. Fentanyl is a super drug and we should have zero tolerance for the distribution of it. [ and we should reschedule and regulate the less harmful drugs ]

@taklamakan666 @danielcberk That’s tough to say- there are people with genetics so unsuited that even if they trained ideally from birth and had access to all the best coaching and tech, would never break 3:30. For the same conditions and with average genetics: probably sub 2:20.

@danielcberk Is 2.30 a exaggeration or a fact? I’m wondering what a normal person could achieve with that you said, but not being a running protege and no elite genetics. I thought 2.10-2.15 is possible no?

If I trained every single day from birth until peak physique in my mid 20s and had millions of dollars for the best coaches, nutritionists, gear, and facilities, I would *maybe* be able to run a marathon in 2:30. I literally can’t comprehend running this fast for this long.

@runawaycoast @rustyrockets Yes haha

@rustyrockets Is that Oz Perlman?

Madness.

@detransanon @gdb Yeah, we need people like you coming up with these scenarios to inform regulation / oversight. I agree with that not being good. Hopefully tools can be used for increased quality versus profit. But healthcare isn’t entirely altruistic souls…

@jslater92 @gdb The idea that my specialist might be using AI to do better actually sounds great, but what worries me is the radiology lab clearing 1000 scans/day with a single supervising licensee or the AI GP that write complete hallucinations in my chart (which I'm then billed for)

Introducing ChatGPT for Clinicians:

@detransanon @gdb I think it’s good to think about out these worst case scenarios. Ideally/hopefully, better research tools boost a clinician’s effectiveness at same patient volume and aren’t an excuse to increase volume with decreased human touch / quality

@jslater92 @gdb As the idea that a doctor who can complete X exams in Y time can complete 2-4x or more with AI's help, quality will rapidly degrade as model companies decrease token limits quietly, sneaking up on providers w/ unexpected and rapid failures, which could kill people.

@detransanon @gdb (typo)….can make mistakes. At end of the day the clinician is responsible for their actions /treatments, whether their advice / education came from a professor, colleague, YouTube video or AI

@detransanon @gdb It’s a new realm for sure. My hunch is clinician’s will make better decisions in aggregate using these tools, though in cases they don’t I think OpenAI has protected themselves with the consent checkboxes one has to click when signing up + their disclosure that AI can makes

@detransanon @gdb The clinician’s malpractice insurance

@gdb If my doctor misdiagnoses me with AI and it harms me, who pays out the malpractice damages?

@thekaransinghal Just activated. Thanks for the thoughtful build!

Today we’re introducing two big steps for health at OpenAI: - ChatGPT for Clinicians, a free version of ChatGPT designed for clinical work - HealthBench Professional, a new benchmark to evaluate real clinician chat tasks We’re excited about what this can unlock for care. ❤️

@iiiitsandrea End of May is kind of when the cool summer breeze is really starting to pick up. It will likely be 65 and breezy.

is SF end of may a good time to go weather wise? also where do people stay usually around Palo Alto? Or is staying in SF still ok to get to Stanford?

@Matt_Schulman1 I just want to say I fully support your usage of San Fran, as someone who lives in SF, and thinks it’s hilarious/silly how peeved people get from hearing it.

Heading to San Fran (as the locals call it). What local-hole-in-the-walls (other than California Pizza Kitchen and Philz Coffee) should I be sure to check out?

@US_Stormwatch I've been analyzing/graphing the snow data recently. Here's a comparison of Feb 20 and March 30 snow totals of recent years, which highlights how crazy the March heat was:

California this wet season: - Wettest Oct–Dec on record in Santa Barbara, Ventura & parts of LA County - Driest & warmest March in state history - 115" February snowstorm + deadly avalanche near Donner Summit - 2nd-lowest spring snowpack on record - Northern Sierra on track for a top-5 wettest April on record - Latest start to ski season ever in parts of the Sierra - 21 straight days of tule fog in the Central Valley - Christmas Day tornado in LA County - 7.5 inches of snow in an hour on Christmas Eve in Mammoth - 40 million people under a flood watch in late December Did I miss anything?

@US_Stormwatch Riveting

I used to feel this way when I would visit. And even soon after I moved here. Now I very regularly am awed at its beauty and character. I’d never live in the Tenderloin, SOMA, parts of the Mission, etc. as they all feel like what you are describing. There’s so much more to it though.

Most of SF feels grimy, dirty, Third World. Unreal that this city is the tech epicenter of the world's most powerful nation. Hard to comprehend how single straight men voluntarily live here.

@sporadica It's terrifying

fwiw i'm more afraid of the growing young/left-wing support for political violence (see: Luigi Mangione, etc) than i am of AI safetyist rhetoric when people started cheering the Titan submersible explosion bc it was some rich guy, I knew things would only get worse from there