Organoid News

Struggling to keep up with all the cool organoid studies? 😉 Science News by @STEMCELLTech brings to you Organoid News, a free email newsletter covering the latest research on organoid models and their applications. 🖱️ Subscribe here: bit.ly/4kkWMEu

Researchers including Dr. Songying Zhang present a microfluidic biofabrication strategy to engineer vascularized endometrial micro-#organoids that recapitulate the cellular complexity and function of native tissue. 🧫 🔎 Take a look in @Biofabrication: bit.ly/47eaYud

Looking to brush up on the basics of cell #cryopreservation? Explore this @STEMCELLTech guide 📑 to find out why it’s useful for the continuity of your research and explore best practices for freezing down your cells in the lab. bit.ly/48iUfY0

Scientists employ their in-house-developed Pick-Flow-Drop platform to enable automated, selective handling of #organoids. 🧫 They reveal how non-genetic heterogeneity influences organoid growth and metabolic activity. 🔎 Learn more: bit.ly/3Pr6sCw

Findings from this @CellStemCell study establish patient-derived #organoid-based epigenetic characterization as a platform for elucidating regulatory mechanisms underlying #BreastCancer progression and for advancing precision therapeutic strategies. 🧫 bit.ly/4bNhV85

Congratulations to @sasaki_kotaro and @Penn colleagues on their new @CellStemCell release! 🎉 They present an #organoid platform offering a powerful tool to dissect human adrenal development. 👣 Follow the link here: bit.ly/4sK7QPc

Organoids have rapidly matured into powerful model systems. 🧫 This @TrendsinBiotech review surveys recent progress at the interface of #organoid research and computational approaches. 📚: bit.ly/3NrBTfg

Shanghai University scientists propose a non-immunogenic, xeno-free, and cytokine-free plant-derived bioink for constructing immune-instructive bone #organoids. 🦴 Read about this platform in @Matter_CP. 📚 bit.ly/4rr8joc

This @Gut_BMJ study established #iPSC-induced multilineage #organoid infection models, confirming Hepatitis E virus' capacity for pan-tissue infection and revealing potential pathogenic mechanisms in the liver, intestine and nervous system. 📖: bit.ly/4dcbmx6

Human #organoids aim to emulate organ microenvironments in vitro and, when cocultured with cancer cells, can provide complementary models. These ‘chimeroids’ may enable scalable studies of cancer–microenvironment interactions. 📖 bit.ly/40YAAYo | @trendscancer

This research published in @NatureComms establishes a West Nile virus #encephalitis model using iPSC-derived cerebral #organoids. Infection results in heterogeneous kinetics with an early strong replication potentially leading to viral clearance. 📖 go.nature.com/40lKdjS

The authors summarize #retinoblastoma pathogenesis, including RB1 loss, and MYCN amplification. They highlight CRISPR-engineered #organoids for identifying cone precursors as tumor origins and validating therapies. 🧫 🔓 bit.ly/4ug1wQK

Scientists from the Korea Research Institute of Bioscience and Biotechnology report the development of a patient-specific, #iPSC-derived multi-organ pharmacokinetics/pharmacodynamics evaluation platform for NF1-mutant #BreastCancer. | @sigtrans_sttt 🧫 go.nature.com/46J1Y05

Using paired individualized #osteosarcoma (OS) #organoid-patient-derived xenograft models, @sjtu1896 researchers show that a PRMT5MTA inhibitor enhances #immunotherapy response in chromosome 9p21.3-deleted OS. 👉 Give it a read in @CellRepMed: bit.ly/4aReLQz

Scientists including Drs. Inga Viktoria Hensel & Martín Resnik-Docampo present an #organoid-on-chip model using human intestinal cells, offering a platform to study barrier function under physiological and pathophysiological conditions. | @iScience_CP 🔓 bit.ly/4seozcU

Join leading innovators at the 11th 3D Tissue Models Summit, with experts from Novo Nordisk, Novartis, Pfizer, AstraZeneca, AbbVie and more shaping the next generation of advanced in vitro models. Discover what’s ahead. Download the brochure today! bit.ly/4t3kF8d Avail 10% discount with 'SSN10' code.

Kick off the week with a new @cddpress review! 📖 The authors summarize the proposed methods for cultivating #organoids consisted of tumor cells and CAFS as well as molecular mechanisms involving in regulating variety of CAF subgroups. 🔗 go.nature.com/3NfdSIl

Looking to stay up to date on the latest cell biology research? Science News by @STEMCELLTech can help. Our website and regular newsletters keep scientists current with the latest peer-reviewed research, as well as industry and policy news. Learn more: bit.ly/3Xn6mwV

.@MCRI_for_kids collaborators including Drs. Svenja Pachernegg and Katie Ayers provide the first comprehensive transcriptional profile of #hiPSC-derived testis-like #organoids. Check it out! 📝: bit.ly/4coW9IR 📙: @Dev_journal

This review explores the utility of #BrainOrganoids in environmental neurotoxicology, which address limitations of traditional models by recapitulating key aspects of human brain development, including 3D cytoarchitecture & functional network activity. bit.ly/4aNrS5j

A new study out of @YaleMed, led by Drs. Sophie Edelstein & Micha Sam Brickman Raredon present a lung #organoid model that varies immune, epithelial, and mesenchymal inputs to reveal how composition dictates epithelial plasticity. | @iScience_CP 🧫 💡 bit.ly/4aSWtNB