Jake

71 posts

Jake

Jake

@justenoughJake

Katılım Temmuz 2022
115 Takip Edilen15 Takipçiler
Jake
Jake@justenoughJake·
@liamsLCjourney @FatigueMe92484 I’ve definitely benefited from it. I combined Enterovite (Apex) and Pendulum’s Metabolic Daily probiotic (Akkermansia + some others). Big improvements in stomach pain, gut health and digestion for me with this combo, but I don’t know the abundance of natural producers in me 🤷‍♂️
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Liam's LC/ME Journey
Liam's LC/ME Journey@liamsLCjourney·
@FatigueMe92484 I'm curious if it's worth taking supplemental butyrate if one has a high number of butyrate producers (like F. Prausnitzii). I am supplementing it right now, but may stop.
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MECFS, MCAS and PTSD
MECFS, MCAS and PTSD@FatigueMe92484·
Butyrate is often deficient in MECFS. It is absorbed through MCT1 , so it's deficiency is an important consequence of my hypothesis! You can access all my posts on butyrate by searching "butyrate" or "SCFA" on my profile.
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DK Pittsburgh Sports
DK Pittsburgh Sports@DKPghSports·
Trevor Zegras always stays out late in warmups to try to shoot into the opponent's empty net. The last two games Evgeni Malkin has waited him out so he could try to block the shot. -- From Taylor Haase in Pittsburgh
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Goob
Goob@goobgleeb·
ahh to be a fat bear floating down a river
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Jake
Jake@justenoughJake·
@Dan_Wyke ME tends to keep the sympathetic nervous system on high, parasympathetic low. I’ve only recently gotten past this hump with guanfacine (inhibits sympathetic and boosts brain blood flow) and vagal stim activities and gadgets. Good luck man, I hope you find something to help soon
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Dan Wyke 🦠➡️🧠🔥
Dan Wyke 🦠➡️🧠🔥@Dan_Wyke·
One thing I hate about ME, that catches me out every time, is how long it takes for my body and mind to let go of even minor stressors. My fight-flight response gets activated at the drop of a hat and the associated thoughts rattle around my head for way longer than is helpful.
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Jake
Jake@justenoughJake·
@scott_scientist Thanks, I appreciate you. I will put my questions below this comment tomorrow at some point when I have a little more energy. Have a good night!
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Scott Daniska
Scott Daniska@scott_scientist·
In all honesty, the reason these trials continue to fail is 100% the fault of the researchers. They are not conducting the scientific method. I ran a research department at a genomics company because I was an expert in the scientific method. 1) Make observations 2) Use critical thinking to analyze the observations 3) Formulate different hypotheses 4) Test the best hypothesis 5) Analyze the data/form a conclusion 6) Return to step 4 (or earlier as necessary) and repeat They aren’t doing any of this. They’re just sitting in the lab running scientific equipment and testing drugs at random. Of course that would not work! The universe won’t exist long enough to test every option at random
Scott Daniska@scott_scientist

More wasted money, time, and extreme needless suffering because ego/reputation are more important to ME/LC researchers than listening to patients for answers.

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Jake
Jake@justenoughJake·
@scott_scientist You seem pretty plugged in to the ME/CFS research community, so that sucks to hear. Would you mind if I asked you some questions about techniques that helped my ME/CFS some time? A functional neurologists’s concussion program cleared it up and I’m pretty confused about it 🤔🤷‍♂️
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Scott Daniska
Scott Daniska@scott_scientist·
@justenoughJake There are lots of curious researchers out there don’t get me wrong, but their curious in their own ideas and way of doing things. Anything outside of their routine can’t possibly be true to them. I’ve seen it for years
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Jake
Jake@justenoughJake·
@scott_scientist Those types of Drs have been problematic for me. I’ve also had the good fortune to see the curious problem solver type of practitioners, and they seem constantly frustrated by systemic constraints. Ugh, it is such a mess!
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Scott Daniska
Scott Daniska@scott_scientist·
@justenoughJake The problem there is 100% willingness to do so. They just want to show up to work, run the same old experiments, collect a paycheck and go home for dinner.
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Jake
Jake@justenoughJake·
@NeuroSjogrens Thanks! I’m probably being overly optimistic about the state I’ll be in this summer but I’m going to look into some local scuba gear rental places anyways :)
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Neuro Sjogrens
Neuro Sjogrens@NeuroSjogrens·
@justenoughJake Glad you're well enough to consider trying these things. I'd personally pick diving. Seems gentler on the system & no frozen beard.
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Jake
Jake@justenoughJake·
@NeuroSjogrens I’ve avoided diving for a while now but maybe that would actually be a good form of gentle exercise for someone with ME. Probably better than winter surfing and growing an ice beard, which has also temped me haha
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Neuro Sjogrens
Neuro Sjogrens@NeuroSjogrens·
@justenoughJake Oh, dude, sounds cold. Apparently shipwrecks there are incredibly well preserved. The cold on your face'll help you w the dive reflex. A nice fleece will go a long way. Let your dive buddies know you can crash & what helps so folks are prepped. Be so 🔥 if you can do this!
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Jake
Jake@justenoughJake·
@scott_scientist That would be amazing to have!! Or some sort of mechanism to corral all the private practices who get to just try things they think work and organize the info they generate so it can be built upon instead of staying isolated
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Scott Daniska
Scott Daniska@scott_scientist·
It’s difficult to move forward with this info exactly because of the close minded research environment we currently have. Imagine if there was a panel of researchers and you could share your experiences/findings with them for 3-5 minutes for them to record and assess? That could be huge but the way things are now they won’t even return your email.
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Jake
Jake@justenoughJake·
@NeuroSjogrens Wow! I didn’t know about the autonomic changes at all. I got certified many many years ago but now I live next to Lake Superior so I’ll need a good dry suit so I can try this 🥶
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Neuro Sjogrens
Neuro Sjogrens@NeuroSjogrens·
@justenoughJake I hope you find something that works. Diving was amazing. The pressures/temp can induce autonomic changes/dive reflexes. It drives gasses into rissues. & who knows what else it does. Good luck if you give it a go. 👍
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Jake
Jake@justenoughJake·
@scott_scientist For the record I am an ABD PhD environmental microbiologist and am very familiar with the research process. My experience has me questioning an awful lot about how we engage in the scientific process (needs more philosophy based research!)
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Jake
Jake@justenoughJake·
@scott_scientist I get it… but is insisting that trying every single point approach really any more feasible when dealing with multi-system neuro-issues? I’ve kicked ME to the curb using a combo of treatments that alone are ineffective or untried and idk how to move forward with this info 🤷‍♂️
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Jake
Jake@justenoughJake·
@scott_scientist Agreed! I haven’t seen much about researchers following up case studies but I’m not as close to it as you are, so that’s nice to hear. Testing 1 thing at a time seems to hold us back too. Systemic disorders probably require systemic treatments and I don’t see a lot of that
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Scott Daniska
Scott Daniska@scott_scientist·
That entirely subjective and up to the grant review board. I know there is a major problem acquiring grant money I do understand that, but I haven’t personally heard of any step 1&2 grant applications being turned down, so our researchers still have to want to do that. But it’s never a good execution of the scientific method to purposefully spend money on a trial you already know will fail. There needs to be accountability for that or else we’re going to keep making the same mistakes. Appreciate your input though, grant funding is an important limitation and it’s good to acknowledge that.
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Jake
Jake@justenoughJake·
@popeyecubs68 @maxlugavere Boosting fiber consumption from 25%-50% of recommended intake probably won’t make the difference in satiety that you expect. Especially on top of all the tricks industrial food chemists use to addict people to their junk food to make them want to eat more
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Roberto Vallarino
Roberto Vallarino@popeyecubs68·
Your comparing to consumption in 1970. You´re stating that increased fiber should help in controlling hunger, but overeating has skyrocketed while fiber has increased. So, there´s no signal there. IF low fiber consumption was not driving overeating in 1970, it´s much less driving it today. Again, the culprit is increased added fat, and absolutely all of it comes from seed oils. This part is not controversial. The question still is why people can´t stop.
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Max Lugavere
Max Lugavere@maxlugavere·
Seed oils have made a lot of people very fat, but not because there’s anything special about the oil. It’s just oil, and a major source of invisible calories in modern diets. You could swap seed oils with any other oil and Americans would be just as fat.
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Jake
Jake@justenoughJake·
@popeyecubs68 @maxlugavere If in 1998, people got 1% of calories from seed oils a 30% increase makes it 1.3% of calories from seed oils. Seriously doubt that would make everyone fat. See what I mean? Graph is useless on its own
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Roberto Vallarino
Roberto Vallarino@popeyecubs68·
It´s % change in calories consumed. It shows that all of the change in calories consumed come from seed oils. Seed oil calories consumed are up more than 30%, while the rest of the diet is flat to down. It´s not meaningless. All the extra calories compared to 1998 come from seed oils.
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Lawrence Elliot
Lawrence Elliot@LawrenceElliots·
Men with predatory spirit intact do not sleep longer than 7 hours. human sleep evolved to be light, fragmented, and variable because deep, rigid, uninterruptible sleep was a predation risk The organism that required eight controlled hours did not survive the ancestral environment but the organism that could operate on variable, interrupted sleep did. The eight-hour recommendation derives from epidemiological data on modern populations saturated with artificial light, chronic sedentary behaviour, and metabolic dysfunction. It describes what is statistically average for a sick civilisation.
💯 Matt 💯@troopah_matt

I routinely live on 5.5-6 hours of sleep. Feel perfectly fine. Make progress in the gym. Focused at work. Once a week I might get 8 hours and feel completely cooked. Make it make sense 8 hours per night is a psy op

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Jake
Jake@justenoughJake·
@OneSeaElephant @grok @GutOptimized Yup! Microbes use specialized enzymes to break apart larger food molecules into smaller and smaller ones, eventually extracting the energy and incorporating the smaller bits into whatever new biomass they need
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Ross 🧬🔬
Ross 🧬🔬@GutOptimized·
A reminder One of the world's leading microbiome experts at Stamford, conducted a study on fibre vs fermented food, and found that fibre didn't increase microbiome counts and increased inflammatory markers in 1/3rd of subjects (can't argue bias because this person is plant based/pro fibre). Meanwhile fermented food significantly increased microbiome levels and reduced inflammation. pubmed.ncbi.nlm.nih.gov/34256014/ This isn't an argument fibre is bad and not helpful to the microbiome. It's pointing out how reductionist this comment is from Dr Simpson.
Dr Terry Simpson@drterrysimpson

No fiber actually helps feed the microbiome that produces short chain fatty acids that serve as a tonic for your gut. Please see a registered dietitian if you have questions and not someone who makes stuff up

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Keşfet

@liamsLCjourney @FatigueMe92484 @Dan_Wyke @scott_scientist @NeuroSjogrens @elonmusk @BarackObama @taylorswift13