Katrina Collins, MD || Pathologist

Our latest in @NatRevClinOncol about the role of KIM-1, the hottest blood biomarker in RCC. With @VincentWenxinXu and Joe Bonventre. nature.com/articles/s4157…

Histopathologic Flavors of Metastatic Prostate Carcinoma - "Amphicrine"/prostatic adenocarcinoma with neuroendocrine expression 🔷Tumor cells simultaneously express both prostate and neuroendocrine markers (expression can be patchy) 🔷 High-grade carcinoma without definite small cell features (like Gleason pattern 5) De novo amphicrine sample report (pic 2) Treatment emergent PC sample report (pic 3) Dr Chan #USCAP2026 #pathology #PathX #PathTwitter

New in Virchows Archiv 🔬 FOXL2 immunohistochemistry reliably marks ovarian differentiation in dysgenetic gonads, including ovotesticular cords, supporting its routine use in diagnosing pediatric ovotesticular DSD #PediatricPathology #DSD #FOXL2 Link 👉🏻 link.springer.com/article/10.100…

#Hemepath meets #GUPath Pitfall alert 🚨GATA3/p63➕ in urinary bladder lymphomas (some with colonization of overlying urothelium) may mimic urothelial carcinoma (in situ) Weird bladder tumor? Consider doing a keratin! 👉🏼IJSP read of the day: tinyurl.com/4bu8b7br #PathTwitter

Uropathology webinar ugm-id.zoom.us/meeting/regist…

Join us for #Pathology Grand Rounds TODAY at 12:30 PM ET as @mLage of @mgbpathology & @HarvardMed presents on, Competency-Based Strategies in Graduate Medical Education: Initiatives in Pathology.” @YaleMed tinyurl.com/2yhej7kt

#slidearchiveseries prostatic adenocarcinoma with mucinous component #gupath ✅ prognosis similar to non-mucinous cancers of similar Gleason score ✅ subtract mucin, grade based on underlying architecture ✅ mucin present (≤25 🆚 >25%)  ✅ final classification on resection

#slidearchiveseries mucinous tubular and spindle cell carcinoma #gupath #pathtwitter #pathoutpic 🔬 tubular and spindle cell growth patterns associated myxoid stroma 🎨 CK7, AMACR, VSTM2A (PMID 30285995) @drmehrarohit 🧬 No trisomies 7 / 17 or loss of Chr Y

#slidearchiveseries prostatic adenocarcinoma with mucinous component #gupath ✅ prognosis similar to non-mucinous cancers of similar Gleason score ✅ subtract mucin, grade based on underlying architecture ✅ mucin present (≤25 🆚 >25%)  ✅ final classification on resection

@slusagar @aakasharmand some papers win with the title alone @aakasharmand 👏 ours took the more traditional route 🤓 but the pathology was still pretty great, sharing our adrenal hemangioma case and review with differential worth remembering pubmed.ncbi.nlm.nih.gov/36507066/

baller paper title from @aakasharmand ! we need more creative & catchy manuscript titles like this in path!

#GUpath #endopath cystic adrenal mass 🔬adrenal endothelial cyst ⏬cont'd⏬

@LiangChengMD @oleks_kravtsov @SUNYUpstatePath 👏🏻 👏🏻

How to grade prostate cancer in small biopsy specimens remains one of the most challenging and controversial areas in daily urologic pathology practice. This recent review article published in Urologic Clinics of North America,
“Prostate Cancer Grading: An Update,” by Drs. John Hanna, Gennady Bratslavsky, Jeffrey S. Ross, Oleksandr Kravtsov, provides an excellent practical overview of many real-world diagnostic dilemmas encountered in prostate biopsy interpretation. The review discusses contemporary Gleason grading, Grade Groups, quantification of Gleason pattern 4, cribriform morphology, intraductal carcinoma, grading pitfalls in minute tumor foci, interobserver variability, and emerging AI applications in prostate pathology. Article link: pubmed.ncbi.nlm.nih.gov/41266001/

@garreyf great question! while apical skel muscle does NOT constitute EPE as you well know, there is lit 👇🏼saying it should be reported (risk of + apical margin at RP) in our group, we do include presence/absence of this in our synoptic summary table for prostate bx

'Feelin' Groovy' - florid urothelial metaplasia in a prostate needle biopsy, mimicking basal cell hyperplasia and HGPIN at low magnification; at high magnification cytoplasmic vacuoles (upper R) & nuclear grooves (lower R) in the metaplastic cells aid in identification #gupath

#GUpath bladder ⏬cont'd⏬

🧩 Bladder riddle Inspired by the previous post… Here is another spindle cell neoplasm. 🤔 Bland-looking spindle cells with eosinophilic cytoplasm, oval nuclei, and small round nucleoli. What would be your diagnosis? #DxMindMap #GUPath #BladderPath #PathTwitter @JHUpath

Excited to share our paper published in @Human_Pathology! Incredibly grateful to my mentor, Dr. Tamara Lotan @LotanLab, for her guidance, mentorship, support, & encouragement and collaborators & co-authors @Williamson_SR @PeterArgani @AsraniKaushal @JHUPath Read it here: sciencedirect.com/science/articl…

Research identifies a high-grade renal cell carcinoma with a somatic BRCA2 mutation, showcasing unique histological patterns. This case reinforces shared features among previously reported cases, suggesting a distinct subtype of RCC. bit.ly/4wIJSq2

A multi-institutional study identifies distinct histological features in renal tumors associated with Birt-Hogg-Dubé syndrome, including eosinophilic and clear cell populations. Findings support the classification of these tumors as a unique entity. bit.ly/49bTwaN

In a comparative analysis, 74% of urothelial carcinoma in situ cases were identified using Nectin-4 and CK20 together. This combination outperformed the CK20/p53 and Nectin-4/p53 pairings, indicating a promising diagnostic approach. bit.ly/42M0VtW

VGLL3-rearranged Spindle Cell Rhabdomyoblastic Tumor: A Clinicopathologic and Molecular Genetic Study of 18 Cases with Consistently Indolent Behavior ✅ Just Accepted 📗 @ModernPathology buff.ly/BfBQR4N