Katrina Collins, MD || Pathologist

Happy 20th anniversary to Twitter! Still the best platform for dissemination & absorption of information in the biomedical sciences.

Exciting feature on the Digital Pathology Association in @pathologistmag As highlighted in this feature, the future of pathology is being shaped now—through collaboration, standards, and real-world implementation of digital and AI-driven workflows. 👉 bit.ly/4uD7ECS

academic conferences are crazy because it’s like Let’s go to the most beautiful place in the world and then look at powerpoints for 12 straight hours

'Blooming Boughs" Original Oil Painting by Erin Hanson #WomensArt

Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2 aacrjournals.org/clincancerres/… NF2 loss in renal cell carcinoma defines an aggressive subtype with frequent metastases and poor outcomes. In a cohort of 33 patients, non-immunotherapy regimens showed numerically longer survival than immunotherapy, though not statistically significant. Genomic analyses revealed frequent NF2 mutations and alterations in cell cycle and DNA repair pathways. Transcriptomic data showed increased proliferation and immune suppression, highlighting limited immunotherapy efficacy and the need for molecularly tailored treatment strategies. #KidneyCancer @yekeduz_emre @WeiweiBian @MarcMachaalani @Mustafajsalehmd @eddy_saad @Clara__Steiner @bergsa83 @BradMcG04 @CharleneMantia @PrafulRavi1 @VincentWenxinXu @MichelleDunno17, @DrChoueiri @MikeSerzanMD @OncoAlert 🚨

Survey: Female physicians had higher burnout and lower professional fulfillment than male physicians, with differences in burnout fully mediated by self-valuation, leadership support, values alignment, control over schedule, and EHR helpfulness. ja.ma/4sPF93b

CIS in bladder is hard enough—now add a mimicker 👀😳 40 y M, HIV+. Good news: one stain nails it. 👉 What is the stain? More CIS mimickers in the thread 👇 #DxMindmap #GUpath #Bladdercancer #PathTwitter #JHUpath

Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system onlinelibrary.wiley.com/doi/10.1111/hi… #GIpath

Have you heard the exciting news? Record breaking numbers for the pathology match leaving zero unfilled spots. Strong work #PathX @MatchToPath @path_SIG @ASCP_Chicago @TheUSCAP @Pathologists

Virchows Archiv discusses the importance of tailored governance mechanisms for digital pathology transformation. The proposed "Three I Framework" aims to operationalize principles for sustainable change in laboratories. bit.ly/4sSQEqH

This image paper details a 23-year-old woman with monophasic synovial sarcoma of the lower lip, featuring a rare MN1::SSX1 fusion. Initial tests were negative, highlighting diagnostic challenges in rare variants. bit.ly/3PfhOtq

@SpringerPath @HHPathology #hartfordstrong 👏🏻

Intestinal spirochetosis, caused by Brachyspira spp, cross reacts with the T. pallidum immunohistochemical stain. Pettit C, et al. Highlighting a Potential Pitfall: Positive Treponema pallidum Immunohistochemical Stain in a Patient Without Syphilis. PMID: 31389806.

This is not a complicated #GUPath case. These prostate glands are "too many, too small, and too crowded" to be benign. They also "cross the street" (i.e. traverse the entire width of the bx core). Other soft signs of PCA which, imo, are very helpful are seen here: crystals & amorphous pink secretions. Nucleoli aren't as prominent as one would want them, but the amphophilic quality of the cytoplasm is another, often neglected clue for PCA. Dx. GS336 prostate carcinoma (#IHCPath is CK5/p63 showing lack of basal cells) Some cases are more subtle! These are the ones where the mantra "always trust the crystals" really comes in handy 😌 x.com/MirunaPopescu1…

Registration is open for the Job Prep Bootcamp. Early in practice or taking a new role? This live virtual program focuses on real-world cases and professional development. 24 CME-accredited sessions, May 2–3 & May 16–17. Early bird pricing ends April 11! capatholo.gy/4sgwiri

🙋🏻‍♂️45 Y 🤕 Renal mass Mucinous tubular and spindle cell carcinoma (MTSCC): • Well demarcated tumor. • Anastomosing tubules with LG nuclei merging with bland spindle cells in mucinous stroma. • Like papRCC: aggregates of foamy macrophages, KRT 7 +, AMACR + • Indolent behavior 😮‍💨 #GUPath #Pathology #PathX #PathTwitter

New in #HumPathol: Detection of Human Papillomavirus with Low-Risk Chromogenic in Situ Hybridization Probes in Seborrheic Keratosis-Like Lesions of the Male Genital Tract. sciencedirect.com/science/articl… #pathology #PathTwitter #PathX #GUpath

Let’s play pathology math 🧮 Middle-aged male + paratesticular mass + bland spindle cells − MDM2 − Calretinin − ALK = ? Dx = Possibilities − excluded differentials (See differential clue in the thread 👇) #DxMindmap #GUpath #PathTwitter #Paratesticularmass

Urothelium after intravesical mitomycin can show striking cytologic atypia—enlarged hyperchromatic nuclei, smudgy chromatin, and degenerative changes that may mimic carcinoma. Clinical history is key to avoid overcalling malignancy. Always correlate with recent treatment. #GUpath

The art of grossing. A 24 man with a right testicular mass. 1.8x1.5cm peripheral nodule (PN) and 2.8x1.4cm adjacent mass. Final Dx. Teratoma(PN)(30%)Embryonal Carcinoma(70%). #pathologists #pathresidents #GUpath #pathTweeter ⁦@SLAPpatologia⁩