Dacre Knight, MD, MS, FACP
2.8K posts
@knidac
Associate Professor of Medicine @UVADOM | Internal Medicine | Medical Director UVA Health EDS Center | AI | @USAirForce Veteran
Our 5/2 Monthly Medical Roundtable @WJCTNews @FCConair Falling fertility rates, lowering blood pressure, smart contact lenses, violence in hospitals, the menopause market, and GLP-1 realities With @uvahealthnews @YourGyneGuru @knidac @MayoClinic @TinaArdon @carlyakramer @heatherschatz @asuhealth
A 𝐦𝐚𝐬𝐭 𝐜𝐞𝐥𝐥 is a tissue-resident hematopoietic effector cell that resides in vascularized tissues, with greatest densities in mucosal and cutaneous barrier tissues. Although mast cells are sentinels of innate immunity and host defense, they are best known as effector cells in allergic responses, owing to their expression of a high-affinity IgE receptor and their generation of abundant lipid mediators (e.g., leukotrienes and prostaglandin D₂), their release of preformed histamine and proteases, and their generation of cytokines and chemokines in response to activation. These mediators have roles in asthma, rhinitis, urticaria, and anaphylaxis. To learn more about this NEJM Illustrated Glossary term, read the Clinical Implications of Basic Research article “A New Stage for Seasoned Actors — Food Anaphylaxis and the Cysteinyl Leukotrienes” by Joshua A. Boyce, MD, from @BrighamWomens and @harvardmed: nej.md/4rp7MEL Explore more terms: nej.md/glossary
